2-methoxytropolone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-Methoxytropolone is a naturally occurring compound found in various plant species. It exhibits a range of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Its unique structure, containing a seven-membered tropolone ring with a methoxy substituent, contributes to its biological activity. Research interest in 2-methoxytropolone stems from its potential therapeutic applications. Studies have explored its synthesis through various methods, including the oxidation of tropolone derivatives. Its effects on different biological systems, including its interaction with enzymes and receptors, are under investigation. The compound has also been studied for its potential as a lead molecule for the development of new drugs.'

Cross-References

ID Source	ID
PubMed CID	16546
SCHEMBL ID	7227687
MeSH ID	M0112491

Synonyms (26)

Synonym
alpha-methoxytropone
2-methoxytropolone
tropolone methyl ether
brn 2041321
2-methoxycycloheptatrienone
2-c-methoxytropone
2-methoxytropone
2-methoxy-2,4,6-cycloheptatrien-1-one
2,4,6-cycloheptatrien-1-one, 2-methoxy-
2-methoxycyclohepta-2,4,6-trien-1-one
AKOS006276242
4-08-00-00161 (beilstein handbook reference)
2-methoxy-2,4,6-cycloheptatrienone
2161-40-2
SCHEMBL7227687
.alpha.-tropolone methyl ether
.alpha.-methoxytropone
DTXSID90175993
2-methoxycyclohepta-2,4,6-trienone
M2576
mfcd01734435
T72082
EX-A4280
CS-0356522
EN300-7471067
CAA16140

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (12.50)	18.7374
1990's	5 (62.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.74 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.94 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.74)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	3.23	6	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
phenylpropanolamine Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.. phenylpropanolamine : An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group. A decongestant and appetite suppressant, it is commonly used in prescription and over-the-counter cough and cold preparations.. (-)-norephedrine : An amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid.	2.04	1	amphetamines; phenethylamine alkaloid	plant metabolite
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	1.96	1	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
tropolone Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).. tropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.	3.49	8	alpha-hydroxy ketone; cyclic ketone; enol	bacterial metabolite; fungicide; toxin
2,4,5-trimethoxybenzaldehyde asaronaldehyde: from Piper clusii (Piperaceae); structure in first source	1.99	1	carbonyl compound
2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone: structure given in first source	1.99	1
trifluoromethanesulfonic acid trifluoromethanesulfonic acid: deblocking reagent for peptide synthesis; RN given refers to parent cpd. triflic acid : A one-carbon compound that is methanesulfonic acid in which the hydrogens attached to the methyl carbon have been replaced by fluorines.	2.08	1	one-carbon compound; perfluoroalkanesulfonic acid
ikp 104 IKP 104: structure given in first source	1.99	1
2,3,4,4'-tetramethoxy-1,1'-biphenyl 2,3,4,4'-tetramethoxy-1,1'-biphenyl: structure given in first source	1.97	1
allocolchicine allocolchicine: not allo-isomer of colchicine; structure given in first source; RN given refers to (S)-isomer	1.98	1

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