Compounds > 16-ketoestradiol
Page last updated: 2024-11-06

16-ketoestradiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

16-ketoestradiol: RN given refers to (17beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID66417
CHEMBL ID1627347
CHEBI ID34165
SCHEMBL ID928512
MeSH IDM0044623

Synonyms (42)

Synonym
566-75-6
estra-1,5(10)-trien-16-one, 3,17-dihydroxy-, (17.beta.)-
nsc-51169
nsc51169
16-ketoestradiol
16-oxo-17beta-estradiol
(17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-one
(8r,9s,13s,14s,17r)-3,17-dihydroxy-13-methyl-7,8,9,11,12,14,15,17-octahydro-6h-cyclopenta[a]phenanthren-16-one
LMST02010047
CHEMBL1627347
chebi:34165 ,
unii-6ce096rr70
nsc 51169
6ce096rr70 ,
16-oxoestradiol
estra-1,3,5(10)-triene-3beta,17beta-diol-16-one
estra-1,3,5(10)-trien-16-one, 3,17-dihydroxy-, (17beta)-
SCHEMBL928512
3,17-dihydroxyestra-1,3,5(10)-trien-16-one #
KJDGFQJCHFJTRH-YONAWACDSA-N
estra-1,3,5(10)-trien-16-one, 3,17-dihydroxy-, (17.beta.)-
(17r)-3,17.beta.-dihydroxy-1,3,5(10)-estratriene-16-one
3,17.beta.-dihydroxyestra-1,3,5(10)-trien-16-one
16-keto-17.beta.-estradiol
estra-1,3,5(10)-trien-16-one, 3,17.beta.-dihydroxy-
DTXSID5040386
J108.088A ,
16-keto-17beta-estradiol
16-keto-estriol
16-oxo-17b-estradiol
16-keto-17b-estradiol
16-oxoestradiol-17b
1,3,5(10)-estratriene-3,17b-diol-16-one
3,17b-dihydroxyestra-1,3,5(10)-trien-16-one
3,17beta-dihydroxyestra-1,3,5(10)-trien-16-one
Q27115859
16-keto-17- beta -estradiol
16-keto 17?-estradiol
16-keto 17beta-estradiol
16-keto-17-beta-estradiol
PD053504
(1r,3as,3br,9bs,11as)-1,7-dihydroxy-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-2-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
16-oxo steroidAny oxo steroid carrying an oxo group at position 16.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID55149The compound was tested in vitro for its ability to initiate DNA replication1998Journal of medicinal chemistry, Apr-23, Volume: 41, Issue:9
Effect of steroids on DNA synthesis in an in vitro replication system: initial quantitative structure-activity relationship studies and construction of a non-estrogen receptor pharmacophore.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (60.00)18.7374
1990's1 (6.67)18.2507
2000's1 (6.67)29.6817
2010's3 (20.00)24.3611
2020's1 (6.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.06 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.89 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.06)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (6.67%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (93.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
estriol
hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone. chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.		4.596116alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		9.98117-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
2-methoxyestradiol
2-methoxy-17beta-estradiol : A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.		2.131017beta-hydroxy steroid;
3-hydroxy steroid		angiogenesis modulating agent;
antimitotic;
antineoplastic agent;
human metabolite;
metabolite;
mouse metabolite
equol
Equol: A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.		6.9310hydroxyisoflavans
16-hydroxyestrone
16-hydroxyestrone: has implications in estrogen physiology & pathophysiology; RN given refers to parent cpd; structure in Negwer, 5th ed, #3670		2.0510
2-hydroxyestradiol
2-hydroxyestradiol: catechol estrogen; RN given refers to (17 beta)-isomer. 2-hydroxy-17beta-estradiol : A 2-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 2.		1.991017beta-hydroxy steroid;
2-hydroxy steroid		carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug
2-hydroxyestrone
2-hydroxyestrone: catechol estrogen which is a major metabolite of estradiol in man & animals; RN given refers to parent cpd. 2-hydroxyestrone : A 2-hydroxy steroid that is estrone substituted by a hydroxy group at position 2.		1.99102-hydroxy steroid;
catechols		human metabolite
2-methoxyestrone
2-methoxyestrone : A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group.		7.693017-oxo steroid;
3-hydroxy steroid;
alicyclic ketone;
aromatic ether;
phenolic steroid;
phenols		human metabolite;
mouse metabolite
4-hydroxyestradiol
4-hydroxyestradiol: catechol estrogen. 4-hydroxy-17beta-estradiol : A 4-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 4.		1.99104-hydroxy steroidmetabolite
pregnanediol
[no description available]		3.5911
4-hydroxyestrone
4-hydroxyestrone : A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4.		2.131017-oxo steroid;
3-hydroxy steroid;
4-hydroxy steroid;
catechols;
phenolic steroid		carcinogenic agent;
estrogen;
human urinary metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Exacerbation
[description not available]		02.3110
Cancer of Prostate
[description not available]		02.3110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.3110
Breast Cancer
[description not available]		03.5911
Breast Neoplasms
Tumors or cancer of the human BREAST.		03.5911
Blood Pressure, High
[description not available]		02.0510
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		02.0510
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.3520