14-deoxy-11-12-didehydroandrographolide and Carbon-Tetrachloride-Poisoning

14-deoxy-11-12-didehydroandrographolide has been researched along with Carbon-Tetrachloride-Poisoning* in 1 studies

Other Studies

1 other study(ies) available for 14-deoxy-11-12-didehydroandrographolide and Carbon-Tetrachloride-Poisoning

Article	Year
Absorption of andrographolides from Andrographis paniculata and its effect on CCl(4)-induced oxidative stress in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:9 A simple and validated high-performance liquid chromatography (HPLC) method with UV detection has been used to determine the content of andrographolide (AP) and 14-deoxy-11,12-didehydroandrographolide (DIAP) in rat plasma after oral dose of methanol extract (1 g/kg body weight) of Andrographis paniculata leaf. An increase in plasma concentration of AP and DIAP was observed from 30 min to 3 h after oral administration of the extract. The maximum plasma concentrations of AP and DIAP were 1.42+/-0.09 microg/ml and 1.31+/-0.04 microg/ml, respectively. Fourteen days oral treatment of rats with the methanol extract (1 g/kg body weight) followed by CCl(4) administration preserved catalase (CAT), and superoxide dismutase (SOD) activities in erythrocytes, whereas plasma lipid peroxidation, alanine transaminase (ALT) and aspartate transaminase (AST) activities were restored to values comparable with control values. Treatment of rats with CCl(4) did not showed significant alteration (p>0.05) in plasma total antioxidant status (TAS) as compare to values of control group. Topics: Alanine Transaminase; Andrographis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Catalase; Diterpenes; Erythrocytes; Lipid Peroxidation; Oxidative Stress; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances	2009

Article

Year

Absorption of andrographolides from Andrographis paniculata and its effect on CCl(4)-induced oxidative stress in rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:9

A simple and validated high-performance liquid chromatography (HPLC) method with UV detection has been used to determine the content of andrographolide (AP) and 14-deoxy-11,12-didehydroandrographolide (DIAP) in rat plasma after oral dose of methanol extract (1 g/kg body weight) of Andrographis paniculata leaf. An increase in plasma concentration of AP and DIAP was observed from 30 min to 3 h after oral administration of the extract. The maximum plasma concentrations of AP and DIAP were 1.42+/-0.09 microg/ml and 1.31+/-0.04 microg/ml, respectively. Fourteen days oral treatment of rats with the methanol extract (1 g/kg body weight) followed by CCl(4) administration preserved catalase (CAT), and superoxide dismutase (SOD) activities in erythrocytes, whereas plasma lipid peroxidation, alanine transaminase (ALT) and aspartate transaminase (AST) activities were restored to values comparable with control values. Treatment of rats with CCl(4) did not showed significant alteration (p>0.05) in plasma total antioxidant status (TAS) as compare to values of control group.

Topics: Alanine Transaminase; Andrographis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Catalase; Diterpenes; Erythrocytes; Lipid Peroxidation; Oxidative Stress; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2009