A lanosterol synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48449]
EC 5.4.99.7;
2,3-epoxysqualene--lanosterol cyclase;
Oxidosqualene--lanosterol cyclase;
OSC;
hOSC
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ro 48-8071 | Homo sapiens (human) | IC50 | 0.0793 | 3 | 3 |
| dodecyldimethylamine oxide | Homo sapiens (human) | IC50 | 4.2300 | 2 | 2 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| lanosterol synthase activity | molecular function | Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. [EC:5.4.99.7, RHEA:14621] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| steroid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators] |
| cholesterol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai] |
| triterpenoid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units. [GOC:go_curators] |
| regulation of protein stability | biological process | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb] |