Page last updated: 2024-10-06

Nucleotide catabolism

Proteins (29)

ProteinSynonymsTaxonomy
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1dNTPase; EC 3.1.5.-; Dendritic cell-derived IFNG-induced protein; DCIP; Monocyte protein 5; MOP-5; SAM domain and HD domain-containing protein 1; hSAMHD1Homo sapiens (human)
Xanthine dehydrogenase/oxidaseHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 2NTPDase 2; EC 3.6.1.-; CD39 antigen-like 1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPDase 2; Ecto-ATPase 2Homo sapiens (human)
Cytosolic purine 5'-nucleotidaseEC 3.1.3.5; Cytosolic 5'-nucleotidase IIHomo sapiens (human)
5'(3')-deoxyribonucleotidase, mitochondrial5',3'-nucleotidase, mitochondrial; EC 3.1.3.-; Deoxy-5'-nucleotidase 2; dNT-2Homo sapiens (human)
Dihydropyrimidine dehydrogenase [NADP(+)]DHPDHase; DPD; EC 1.3.1.2; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenaseHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 3NTPDase 3; EC 3.6.1.5; CD39 antigen-like 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ecto-ATPase 3; Ecto-apyrase 3; HB6Homo sapiens (human)
Thymidine phosphorylaseTP; EC 2.4.2.4; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPaseHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 8E-NTPDase 8; NTPDase 8; NTPDase8; EC 3.6.1.5Homo sapiens (human)
Guanine deaminaseGuanase; Guanine aminase; EC 3.5.4.3; Guanine aminohydrolase; GAH; p51-nedasinHomo sapiens (human)
Beta-ureidopropionaseEC 3.5.1.6; BUP-1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolaseHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 4NTPDase 4; EC 3.6.1.15; EC 3.6.1.6; Golgi UDPase; Lysosomal apyrase-like protein of 70 kDa; Uridine-diphosphatase; UDPase; 3.6.1.42Homo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 5NTPDase 5; EC 3.6.1.6; CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5; GDPase ENTPD5; 3.6.1.42; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5Homo sapiens (human)
Purine nucleoside phosphorylasePNP; EC 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylaseHomo sapiens (human)
5'-nucleotidase5'-NT; EC 3.1.3.5; Ecto-5'-nucleotidaseHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 1NTPDase 1; EC 3.6.1.5; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigenHomo sapiens (human)
DihydropyrimidinaseDHP; DHPase; EC 3.5.2.2; Dihydropyrimidine amidohydrolase; HydantoinaseHomo sapiens (human)
2'-deoxynucleoside 5'-phosphate N-hydrolase 1EC 3.2.2.-; c-Myc-responsive protein RCLHomo sapiens (human)
5'(3')-deoxyribonucleotidase, cytosolic typeEC 3.1.3.-; Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1Homo sapiens (human)
Inosine triphosphate pyrophosphatase ITPase; Inosine triphosphatase; EC 3.6.1.9; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase; Putative oncogene protein hlc14-06-pHomo sapiens (human)
Nucleotide triphosphate diphosphatase NUDT15EC 3.6.1.9; MutT homolog 2; MTH2; Nucleoside diphosphate-linked moiety X motif 15; Nudix motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nudix hydrolase 15Homo sapiens (human)
ADP-sugar pyrophosphataseEC 3.6.1.13; 8-oxo-dGDP phosphatase; 3.6.1.58; Nuclear ATP-synthesis protein NUDIX5; 2.7.7.96; Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5; hNUDT5; YSA1HHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 6NTPDase 6; EC 3.6.1.6; CD39 antigen-like 2Homo sapiens (human)
Manganese-dependent ADP-ribose/CDP-alcohol diphosphataseEC 3.6.1.13; EC 3.6.1.16; EC 3.6.1.53; ADPRibase-Mn; CDP-choline phosphohydrolaseHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 7NTPDase 7; EC 3.6.1.15; Lysosomal apyrase-like protein 1Homo sapiens (human)
U8 snoRNA-decapping enzymeEC 3.6.1.62; IDP phosphatase; IDPase; 3.6.1.64; Inosine diphosphate phosphatase; Nucleoside diphosphate-linked moiety X motif 16; Nudix motif 16; Nudix hydrolase 16; U8 snoRNA-binding protein H29K; m7GpppN-mRNA hydrolaseHomo sapiens (human)
Cytosolic 5'-nucleotidase 1BcN1B; EC 3.1.3.5; Autoimmune infertility-related protein; Cytosolic 5'-nucleotidase IB; cN-IBHomo sapiens (human)
Cytosolic 5'-nucleotidase 1AcN1A; EC 3.1.3.5; Cytosolic 5'-nucleotidase IA; cN-I; cN-IAHomo sapiens (human)
Alanine--glyoxylate aminotransferase 2, mitochondrialAGT 2; EC 2.6.1.44; (R)-3-amino-2-methylpropionate--pyruvate transaminase; 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBATHomo sapiens (human)

Compounds (46)

CompoundDescription
hydronium ion
NADH
Ammonium
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
8-oxodeoxyadenosine triphosphate
molybdenum cofactoralso see records for molybdopterin cytosine dinucleotide and molybdopterin guanine dinucleotide
2'-deoxyguanosine 5'-phosphateRN given refers to parent cpd.
deoxyguanosine triphosphate
guanine
Inosine MonophosphateInosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Inosine TriphosphateInosine 5'-(tetrahydrogen triphosphate). An inosine nucleotide containing three phosphate groups esterified to the sugar moiety. Synonym: IRPPP.
deoxyinosine diphosphate
2-hydroxydeoxyadenosine triphosphate
TheophyllineA methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
hypoxanthineA purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.
Inosine DiphosphateAn inosine nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
8-oxo-7,8-dihydro-2'-deoxyguanosine-5'-monophosphate
8-oxo-7,8-dihydrodeoxyguanosine diphosphate
8-hydroxyguanosine triphosphate
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
thymineOne of four constituent bases of DNA.
uracilOne of four nucleotide bases in the nucleic acid RNA.
uric acidAn oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
triphosphate
2-hydroxydeoxyadenosine triphosphate
dihydrouracil
xanthineA purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
xanthosine monophosphate
xanthosine 5'-triphosphateRN given refers to parent cpd
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
5,6-dihydrothymineRN given refers to parent cpd