5,6-dihydrothymine profile

5,6-Dihydrothymine (DHT) is a reduced form of thymine, a major component of DNA. It is a product of thymine's reaction with hydroxyl radicals, which are highly reactive species that can damage DNA. The formation of DHT can lead to mutations and ultimately cell death. The study of DHT is important for understanding the mechanisms of DNA damage and repair, as well as the development of potential therapeutic strategies for preventing and treating DNA damage-related diseases.'

5,6-dihydrothymine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5,6-dihydrothymine : A pyrimidone obtained by formal addition of hydrogen across the 5,6-position of thymine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	93556
CHEBI ID	27468
SCHEMBL ID	48294
MeSH ID	M0126295

Synonym
HMS1790A09
CHEBI:27468
5-methyldihydropyrimidine-2,4(1h,3h)-dione
5,6-dihydro-2,4-dihydroxy-5-methylpyrimidine
nsc-44131
2,3h)-pyrimidinedione, dihydro-5-methyl-
hydrouracil, 5-methyl-
5-methyl-5,6-dihydrouracil
nsc44131
2,4(1h,3h)-pyrimidinedione, dihydro-5-methyl-
C00906
5,6-dihydro-5-methyluracil
5,6-dihydrothymine
696-04-8
dihydrothymine
EBCE7D46-D152-4594-B8D9-5AED7AA2C71A
thymine, 5,6-dihydro-
STL007737
2-hydroxy-5-methyl-5,6-dihydropyrimidin-4(1h)-one
STL042697
5-methyl-1,3-diazinane-2,4-dione
AKOS000121569
A836561
AKOS005697994
einecs 211-787-7
z51mht1w75 ,
nsc 44131
unii-z51mht1w75
ai3-25480
S3702
GEO-01093
FT-0624970
SCHEMBL48294
BBL027888
AKOS016050499
5-methyldihydro-2,4(1h,3h)-pyrimidinedione #
5,6-dihydro thymine
mfcd00023159
5, 6-dihydrothymine
AS-61173
Z55928832
dihydrothymine crystalline
DTXSID30862375
Q3027885
5,6-dihydro thymine-d6
CS-0030750
HY-N6787
CCG-266106
D97440
SB57609
EN300-16467

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
pyrimidone	A pyrimidine carrying one or more oxo substituents.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Metabolism	1496	1108
Nucleotide metabolism	89	125
Nucleotide catabolism	36	71
Pyrimidine catabolism	10	25
Pyrimidine Metabolism	23	53
beta-Ureidopropionase Deficiency	23	53
UMP Synthase Deficiency (Orotic Aciduria)	23	53
Dihydropyrimidinase Deficiency	23	53
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)	23	53
Pyrimidine Nucleotides and Nucleosides metabolism ( Pyrimidine Nucleotides and Nucleosides metabolism )	45	49
NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine ( Pyrimidine Nucleotides and Nucleosides metabolism )	1	4
5,6-Dihydro-thymine + H2O = 3-Ureido-2-methyl-propanoic acid ( Pyrimidine Nucleotides and Nucleosides metabolism )	1	3
thymine degradation	6	13
Pyrimidine metabolism and related diseases	18	44

Assay ID	Title	Year	Journal	Article
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (25.93)	18.7374
1990's	9 (33.33)	18.2507
2000's	6 (22.22)	29.6817
2010's	4 (14.81)	24.3611
2020's	1 (3.70)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (3.57%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (96.43%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
n-carbamoyl-beta-alanine N-carbamoyl-beta-alanine: RN given refers to parent cpd. N-carbamoyl-beta-alanine : A beta-alanine derivative that is propionic acid bearing a ureido group at position 3.	1.97	1	beta-alanine derivative	metabolite; mouse metabolite
adenine [no description available]	1.99	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
beta-alanine [no description available]	1.97	1	amino acid zwitterion; beta-amino acid	agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter
cytosine [no description available]	7.4	2	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
dihydrouracil hexahydropyrimidine-2,4-dione: structure in first source. 5,6-dihydrouracil : A pyrimidine obtained by formal addition of hydrogen across the 5,6-position of uracil.	3.08	5	pyrimidone	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
thymine [no description available]	4.56	25	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	3.5	8	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	1.97	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
thymidine [no description available]	1.96	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
pentoxyl Pentoxyl: 5-Hydroxymethyl-6-methyl- 2,4-(1H,3H)-pyrimidinedione. Uracil derivative used in combination with toxic antibiotics to lessen their toxicity; also to stimulate leukopoiesis and immunity. Synonyms: pentoksil; hydroxymethylmethyluracil.	2.69	3	pyrimidone
tetranitromethane [no description available]	1.96	1	organonitrogen compound
thymine glycol thymine glycol: forms photodimers (thymine dimers) under UV; RN given refers to cpd without isomeric designation	2.89	4	hydroxypyrimidine
5-hydroxymethyluracil [no description available]	2.45	2	primary alcohol; pyrimidone	human metabolite
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	1.96	1	oxygen hydride; oxygen radical; reactive oxygen species
beta-ureidoisobutyric acid beta-ureidoisobutyric acid: structure given in first source. 3-ureidoisobutyric acid : A ureidocarboxylic acid that is 2-methylpropanoic acid substituted by a carbamoylamino group at position 3.	1.97	1	ureidocarboxylic acid	human metabolite; mouse metabolite
5-formyluracil 5-formyluracil: structure. 5-formyluracil : A pyrimidone resulting from the formal oxidation of the alcoholic hydroxy group of 5-hydroxymethyluracil to the corresponding aldehyde. It is a major one-electron photooxidation product of thymine in oligodeoxynucleotides.	2.71	3	aldehyde; nucleobase analogue; pyrimidone	human metabolite; mutagen
5-hydroxycytosine [no description available]	7	1
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	1.99	1	cysteinium	fundamental metabolite
oligonucleotides [no description available]	2.73	3
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	1.98	1
guanine [no description available]	2.71	3	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	2	1	guanosines; purines D-ribonucleoside	fundamental metabolite
8-hydroxyguanosine 8-hydroxyguanosine: immunostimulant for B lymphocytes; structure given in first source	2	1	purine nucleoside
8-hydroxyguanine 7,8-dihydro-8-oxoguanine: was substituted for guanine at G(8), G(9), G(14), or G(15) in the human telomeric oligonucleotide 5'-d[AGGGTTAG(8)G(9)GTT AG(14)G(15)GTTAGGGTGT]-3'. 7,8-dihydro-8-oxoguanine : An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.	2.71	3	oxopurine

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Auditory Processing Disorder, Central [description not available]	2.03	1
Purine Pyrimidine Metabolism, Inborn Errors [description not available]	2.68	3

5,6-dihydrothymine

Description

Cross-References

Synonyms (51)

Roles (3)

Drug Classes (1)

Pathways (14)

Bioassays (2)

Research

Studies (27)

Market Indicators

Research Demand Index: 16.22

Study Types