A nucleoside diphosphate phosphatase ENTPD5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75356]
NTPDase 5;
EC 3.6.1.6;
CD39 antigen-like 4;
ER-UDPase;
Guanosine-diphosphatase ENTPD5;
GDPase ENTPD5;
3.6.1.42;
Nucleoside diphosphatase;
Uridine-diphosphatase ENTPD5;
UDPase ENTPD5
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0) | 18.7374 |
| 1990's | 0 (0) | 18.2507 |
| 2000's | 0 (0) | 29.6817 |
| 2010's | 0 (0) | 24.3611 |
| 2020's | 0 (0) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| chromazonarol | Homo sapiens (human) | IC50 | 10.0000 | 1 | 0 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| GDP phosphatase activity | molecular function | Catalysis of the reaction: GDP + H2O = GMP + phosphate. [PMID:2989286, RHEA:22156] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| CDP phosphatase activity | molecular function | Catalysis of the reaction: CDP + H2O = CMP + phosphate. [GOC:al, RHEA:64880] |
| ADP phosphatase activity | molecular function | Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+. [PMID:1470606, RHEA:61436] |
| UDP phosphatase activity | molecular function | Catalysis of the reaction: UDP + H2O = UMP + phosphate. [RHEA:64876] |
| IDP phosphatase activity | molecular function | Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate. [PMID:20385596, PMID:22849572, RHEA:35207] |
| ribonucleoside triphosphate phosphatase activity | molecular function | Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. [RHEA:23680] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| UDP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate. [ISBN:0198506732] |
| nucleoside diphosphate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732] |