Page last updated: 2024-09-02

r 56865 and verapamil

r 56865 has been researched along with verapamil in 9 studies

Compound Research Comparison

Studies (r 56865)	Trials (r 56865)	Recent Studies (post-2010) (r 56865)	Studies (verapamil)	Trials (verapamil)	Recent Studies (post-2010) (verapamil)
72	1	0	17,621	1,527	2,067

Protein Interaction Comparison

Protein	Taxonomy	verapamil (IC50)
Solute carrier family 22 member 1	Homo sapiens (human)	6.8
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	0.2
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	0.297
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	2
ATP-dependent translocase ABCB1	Homo sapiens (human)	2.2346
Cytochrome P450 3A4	Homo sapiens (human)	3.8008
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.579
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	3.02
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	10
Catechol O-methyltransferase	Homo sapiens (human)	0.2
Potassium voltage-gated channel subfamily A member 3	Homo sapiens (human)	8
Histamine H2 receptor	Homo sapiens (human)	2.59
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	0.442
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	0.297
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	3.02
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.24
Multidrug resistance-associated protein 1	Homo sapiens (human)	5.598
D(3) dopamine receptor	Homo sapiens (human)	0.186
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	0.165
5-hydroxytryptamine receptor 7	Cavia porcellus (domestic guinea pig)	6.8
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	0.2
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	0.3945
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	0.2
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	1.1934

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (11.11)	18.7374
1990's	8 (88.89)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Borgers, M; Thoné, F; Vandeplassche, G	1
Peters, T; Scheufler, E	1
Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G	1
Koch, P; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wilhelm, D	1
Park, SR; Ryu, GH; Suh, CK	1
De Clerck, F; Lu, HR	1
De Clerck, F; Lu, HR; Remeysen, P	1
Guttmann, I; Mozes, A; Scheufler, E; Wilffert, B	1
Dai, DZ; De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Yang, P	1

Other Studies

9 other study(ies) available for r 56865 and verapamil

Article	Year
Protective effects of R 56 865 against ischemic damage in the isolated rabbit heart. European journal of pharmacology, 1991, Sep-17, Volume: 202, Issue:2 Topics: Animals; Benzothiazoles; Calcium; Calcium Channels; Cell Death; Coronary Disease; Female; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Subcellular Fractions; Thiazoles; Verapamil	1991
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue. Cell biology international reports, 1990, Volume: 14, Issue:4 Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil	1990
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes. Cell biology international reports, 1990, Volume: 14, Issue:4 Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil	1990
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta. European journal of pharmacology, 1988, Dec-13, Volume: 158, Issue:3 Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil	1988
Cardioprotective drugs decrease the Na+ background current. Yonsei medical journal, 1995, Volume: 36, Issue:3 Topics: Amiloride; Animals; Benzothiazoles; Guinea Pigs; Heart; Heart Arrest, Induced; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil	1995
R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1 Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Dose-Response Relationship, Drug; Hemodynamics; Lidocaine; Male; Piperidines; Random Allocation; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Verapamil	1993
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs. European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil	1993
R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion. Cardiovascular drugs and therapy, 1995, Volume: 9, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzothiazoles; Calcium; Calcium Channel Blockers; Extracellular Space; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil	1995
Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx. European journal of pharmacology, 1999, Jan-22, Volume: 365, Issue:2-3 Topics: Amiloride; Anesthesia; Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Heart Rate; Lidocaine; Male; Myocardial Reperfusion Injury; Piperidines; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Sodium Channels; Thiazoles; Verapamil	1999