Compounds > piperaquine
Page last updated: 2024-09-03

piperaquine and verapamil

piperaquine has been researched along with verapamil in 3 studies

Compound Research Comparison

Studies
(piperaquine)		Trials
(piperaquine)		Recent Studies (post-2010)
(piperaquine)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
63822749717,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomypiperaquine (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Masseno, V; Muriithi, S; Nzila, A1
Brun, R; Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, MK; Smilkstein, MJ; Winter, R; Wittlin, S1
Ariey, F; Dhingra, SK; Fairhurst, RM; Fidock, DA; Kümpornsin, K; Menard, D; Mok, S; Ross, LS; Takala-Harrison, S; Wicht, KJ; Witkowski, B; Yeo, T1

Other Studies

3 other study(ies) available for piperaquine and verapamil

ArticleYear
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

    Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil

2009
Discovery of dual function acridones as a new antimalarial chemotype.
    Nature, 2009, May-14, Volume: 459, Issue:7244

    Topics: Acridones; Animals; Antimalarials; Drug Discovery; Drug Resistance; Drug Synergism; Heme; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Plasmodium yoelii; Protozoan Proteins; Quinine; Quinolines; Trophozoites; Verapamil

2009
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
    Nature communications, 2018, 08-17, Volume: 9, Issue:1

    Topics: Animals; Antimalarials; Cambodia; Cell Shape; Chloroquine; Drug Resistance; Gene Dosage; Gene Editing; Haplotypes; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutation; Parasites; Plasmodium falciparum; Protozoan Proteins; Quinolines; Verapamil

2018