mk 0663 has been researched along with ibuprofen in 24 studies
| Studies (mk 0663) | Trials (mk 0663) | Recent Studies (post-2010) (mk 0663) | Studies (ibuprofen) | Trials (ibuprofen) | Recent Studies (post-2010) (ibuprofen) |
|---|---|---|---|---|---|
| 549 | 173 | 265 | 10,245 | 1,781 | 4,267 |
| Protein | Taxonomy | mk 0663 (IC50) | ibuprofen (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 2.9 | |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 1.1 | |
| Albumin | Bos taurus (cattle) | 3 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 4.0919 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 0.22 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 1.6273 | |
| Caspase-1 | Homo sapiens (human) | 7.2667 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 1.1 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 3.0687 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 1.3 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 10 | |
| Caspase-3 | Homo sapiens (human) | 7.2667 | |
| Caspase-4 | Homo sapiens (human) | 7.2667 | |
| 4-aminobutyrate aminotransferase, mitochondrial | Rattus norvegicus (Norway rat) | 1.1 | |
| Caspase-5 | Homo sapiens (human) | 7.2667 | |
| Caspase-9 | Homo sapiens (human) | 7.2667 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 1.1375 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 2.9 | |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | 5 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.54 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 8 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 1.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Castrejón-Flores, JL; Franco-Hernández, MO; García-Aranda, MI; García-Báez, EV; Gómez-Castro, CZ; Gómez-Gómez, YM; Gonzalez-Padilla, JE; Padilla-Martínez, II; Rosales-Hernández, MC | 1 |
| Ouellet, M; Percival, MD; Riendeau, D | 1 |
| Bowen, B; Callegari, P; Evans, J; Harper, S; Hunt, RH; James, C; Quan, H; Rashid, F; Yu, C | 1 |
| Evans, JK; Harper, S; Hunt, RH; Lee, M; Oxenius, B; Quan, H; Watson, DJ; Yu, C | 1 |
| Aversano, ML; Boice, JA; Ko, A; Murphy, FT; Reicin, AS; Sheldon, EA; Wiesenhutter, CW; Wittmer, BA | 1 |
| Berrocal, A; Boice, JA; Cichanowitz, N; Fidelholtz, JL; Ko, A; Littlejohn, TW; Miranda, P; Puopolo, A; Reicin, AS | 1 |
| Bandy, DP; Boice, J; Christensen, SE; Daniels, SE; Liu, H; Losada, MC; Mehta, A; Peloso, PM | 1 |
| Derry, S; McQuay, HJ; Moore, AR; Paine, J; Straube, S | 1 |
| Janovsky, M; Krsiak, M | 1 |
| Micu, MC; Micu, R; Ostensen, M | 1 |
| Blanca, M; Blanca-López, N; Campo, P; Canto, G; Doña, I; Fernández, J; Gómez, AI; Jagemann, LR; Laguna, JJ; Rondón, C; Rosado, A; Torres, MJ | 1 |
| Kasemier, J; Meek, IL; Movig, KL; van de Laar, MA; Vonkeman, HE | 1 |
| Chen, L; Chitkara, DK; Curtis, SP; Mehta, A; Minkowitz, HS; Papanicolaou, DA; Peloso, PM; Rawal, N; Shah, S; Viscusi, E | 1 |
| Chang, Q; Di, W; Hua, Q; Li, X; Liu, J; Mehta, A; Yan, L; Yao, Y; Yu, Q; Yu, W; Zhang, X; Zhang, Y; Zhu, X; Zou, Q | 1 |
| Dulski, M; Paluch, M; Rams-Baron, M; Ratuszna, A; Wojnarowska, Z | 1 |
| Baglie, S; Baller, EM; Franco, GC; Gevert, MV; Lupepsa, AC; Moro, MG; Sanchez, PK; Tostes, AF | 1 |
| Khehra, HS; Piepho, HP; Sandhu, SS | 1 |
| Albuquerque, AFM; Bezerra, MM; Chaves, HV; Costa, FWG; de Barros Silva, PG; de Lima, BB; do Val, DR; Fonteles, CSR; Pereira, KMA; Ribeiro, TR; Soares, ECS | 1 |
| Bojkova, D; Charlesworth, B; Ciesek, S; Cinatl, J; de Bruin, N; Gribbon, P; Kannt, A; Laughey, WF; Lodhi, I; Pennick, G; Reus, P; Schiffmann, S; Schneider, AK; Sinclair, S; Talmon, S | 1 |
| Hjemdahl, P; Stiller, CO | 1 |
| Alvarenga-Brant, R; Costa, FO; Cota, LOM; Esteves-Lima, RP; Mattos-Pereira, GH | 1 |
3 review(s) available for mk 0663 and ibuprofen
| Article | Year |
|---|---|
Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Drug Therapy, Combination; Etoricoxib; Female; Humans; Ibuprofen; Male; Molar, Third; Pain, Postoperative; Pyridines; Randomized Controlled Trials as Topic; Sulfones; Tooth Extraction; Treatment Outcome; Young Adult | 2011 |
Comparing the effectiveness profile of pharmacological interventions used for orthodontic pain relief: an arm-based multilevel network meta-analysis of longitudinal data.
Topics: Acetaminophen; Analgesics; Drug Administration Schedule; Etoricoxib; Humans; Ibuprofen; Network Meta-Analysis; Orthodontics, Corrective; Pain; Pain Management; Randomized Controlled Trials as Topic | 2017 |
Lessons from 20 years with COX-2 inhibitors: Importance of dose-response considerations and fair play in comparative trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Fibrinolytic Agents; Humans; Ibuprofen; Lactones; Naproxen; Prostaglandins; Prostaglandins I; Sulfones; Thromboxanes | 2022 |
11 trial(s) available for mk 0663 and ibuprofen
| Article | Year |
|---|---|
Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Etoricoxib; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Isoenzymes; Male; Membrane Proteins; Middle Aged; Occult Blood; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyridines; Stomach Ulcer; Sulfones | 2003 |
The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Endoscopy; Etoricoxib; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Incidence; Isoenzymes; Male; Membrane Proteins; Meta-Analysis as Topic; Middle Aged; Peptic Ulcer; Peptic Ulcer Perforation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfones; Treatment Outcome | 2003 |
Evaluation of the comparative efficacy of etoricoxib and ibuprofen for treatment of patients with osteoarthritis: A randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Etoricoxib; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; Pyridines; Sulfones | 2005 |
A randomized placebo-controlled trial comparing the efficacy of etoricoxib 30 mg and ibuprofen 2400 mg for the treatment of patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Cyclooxygenase Inhibitors; Double-Blind Method; Etoricoxib; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; Pain Measurement; Placebos; Pyridines; Statistics as Topic; Sulfones; Treatment Outcome | 2007 |
Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model.
Topics: Acetaminophen; Adolescent; Adult; Anesthesia, Dental; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Etoricoxib; Female; Humans; Ibuprofen; Least-Squares Analysis; Male; Molar, Third; Pain; Pain Measurement; Pain, Postoperative; Pyridines; Sulfones; Tooth Extraction; Tooth, Impacted; Treatment Outcome; Young Adult | 2011 |
Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adolescent; Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Hypersensitivity; Etoricoxib; Humans; Hypersensitivity, Immediate; Ibuprofen; Pyridines; Single-Blind Method; Sulfones; Urticaria; Young Adult | 2011 |
Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: a placebo-controlled, ex vivo, serial placebo-controlled serial crossover study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Administration Schedule; Drug Interactions; Etoricoxib; Female; Humans; Ibuprofen; Male; Meloxicam; Middle Aged; Naproxen; Netherlands; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Pyridines; Risk Assessment; Sulfones; Thiazines; Thiazoles; Time Factors; Young Adult | 2013 |
Evaluation of etoricoxib in patients undergoing total knee replacement surgery in a double-blind, randomized controlled trial.
Topics: Aged; Arthroplasty, Replacement, Knee; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Etoricoxib; Female; Humans; Ibuprofen; Male; Middle Aged; Morphine; Narcotics; Pain, Postoperative; Pyridines; Sulfones | 2013 |
Etoricoxib in the treatment of primary dysmenorrhea in Chinese patients: a randomized controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; China; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Dysmenorrhea; Etoricoxib; Female; Humans; Ibuprofen; Pain Measurement; Pyridines; Severity of Illness Index; Sulfones; Treatment Outcome | 2014 |
Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study.
Topics: Adolescent; Adult; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Etoricoxib; Female; Humans; Ibuprofen; Interleukin-1beta; Male; Molar, Third; Pain Management; Pain Measurement; Pain, Postoperative; Placebos; Pyridines; Sulfones; Tooth Extraction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single-implant surgery: A randomized clinical trial.
Topics: Acetaminophen; Dental Implants; Double-Blind Method; Etoricoxib; Female; Humans; Ibuprofen; Male; Middle Aged; Pain, Postoperative | 2023 |
10 other study(ies) available for mk 0663 and ibuprofen
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Humans; Inflammation; Male; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Structure-Activity Relationship | 2020 |
Investigational COX-2 inhibitor relieves pain in dental model.
Topics: Adolescent; Adult; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Etoricoxib; Humans; Ibuprofen; Middle Aged; Pain; Pyridines; Randomized Controlled Trials as Topic; Sulfones; Tooth Extraction; Treatment Outcome | 2001 |
A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin.
Topics: Acetylation; Animals; Aspirin; Blood Platelets; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Humans; Ibuprofen; In Vitro Techniques; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sheep; Sulfonamides; Sulfones | 2001 |
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.
Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Celecoxib; Codeine; Cyclooxygenase 2 Inhibitors; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Etoricoxib; Ibuprofen; Male; Mice; Mice, Inbred Strains; Models, Animal; Pain; Pyrazoles; Pyridines; Regression Analysis; Sulfonamides; Sulfones | 2011 |
Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chi-Square Distribution; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Female; Fertility; Humans; Ibuprofen; Infertility, Female; Inflammation; Norway; Ovarian Follicle; Ovulation; Pregnancy; Prospective Studies; Pyridines; Rheumatic Diseases; Risk Assessment; Risk Factors; Sulfones; Ultrasonography | 2011 |
Evidence of slow Debye-like relaxation in the anti-inflammatory agent etoricoxib.
Topics: Computer Simulation; Cyclooxygenase 2 Inhibitors; Dielectric Spectroscopy; Etoricoxib; Hydrogen Bonding; Ibuprofen; Models, Chemical; Protons; Pyridines; Sulfones; Temperature | 2015 |
Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Creatinine; Cyclooxygenase 2 Inhibitors; Etoricoxib; Gastric Mucosa; Ibuprofen; Kidney; Kidney Diseases; Male; Platelet Aggregation Inhibitors; Pyridines; Random Allocation; Rats, Wistar; Risk Factors; Stomach Diseases; Sulfones; Time Factors; Treatment Outcome | 2016 |
Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.
Topics: Acetaminophen; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; COVID-19; Disease Progression; Enzyme Activation; Etoricoxib; Flurbiprofen; Gene Expression Regulation, Enzymologic; Humans; Ibuprofen; Male; Mice; Mice, Inbred C57BL; SARS-CoV-2; Virus Internalization | 2022 |