Compounds > mcn 5691
Page last updated: 2024-09-03

mcn 5691 and verapamil

mcn 5691 has been researched along with verapamil in 2 studies

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

Compound Research Comparison

Studies
(mcn 5691)		Trials
(mcn 5691)		Recent Studies (post-2010)
(mcn 5691)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
70017,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomymcn 5691 (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Almond, HR; Brannan, MD; Carmosin, RJ; Carson, JR; Flaim, SF; Gill, A; Gleason, MM; Keely, SL; Ludovici, DW; Pitis, PM1
Brannan, MD; Damiano, BP; Flaim, SF; Gill, A; Stump, GL1

Other Studies

2 other study(ies) available for mcn 5691 and verapamil

ArticleYear
2-Ethynylbenzenealkanamines. A new class of calcium entry blockers.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:3

    Topics: Alkynes; Amines; Animals; Calcium Channel Blockers; Coronary Circulation; Guinea Pigs; Hypertension; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Vasodilation

1988
Cardiac electrophysiologic effects of McN-5691, a new calcium-channel blocking antihypertensive agent.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:4

    Topics: Action Potentials; Analysis of Variance; Animals; Antihypertensive Agents; Atrioventricular Node; Calcium Channel Blockers; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Female; Heart; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Propylamines; Purkinje Fibers; Verapamil

1990