Page last updated: 2024-09-05

biotin and cyclosporine

biotin has been researched along with cyclosporine in 10 studies

Compound Research Comparison

Studies
(biotin)
Trials
(biotin)
Recent Studies (post-2010)
(biotin)
Studies
(cyclosporine)
Trials
(cyclosporine)
Recent Studies (post-2010) (cyclosporine)
14,847953,8823772170
14,847953,88230,5473,8026,558

Protein Interaction Comparison

ProteinTaxonomybiotin (IC50)cyclosporine (IC50)
ATP-binding cassette sub-family C member 3Homo sapiens (human)0.6315
Bile salt export pumpRattus norvegicus (Norway rat)0.6
Bile salt export pumpHomo sapiens (human)3.5
Interleukin-2Mus musculus (house mouse)0.005
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.6792
Cytochrome P450 3A4Homo sapiens (human)3.734
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 25.82
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A5Homo sapiens (human)2.06
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
Substance-K receptorHomo sapiens (human)4.139
Peptidyl-prolyl cis-trans isomerase BHomo sapiens (human)0.0088
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A7Homo sapiens (human)2.06
Cytochrome P450 2C19Homo sapiens (human)7
Multidrug resistance-associated protein 1 Homo sapiens (human)3.5082
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)9.34
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4Homo sapiens (human)0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.183
Peptidyl-prolyl cis-trans isomerase DHomo sapiens (human)0.0036
Sodium/bile acid cotransporterHomo sapiens (human)1
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.455
Cytochrome P450 3A43 Homo sapiens (human)2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (house mouse)0.57
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.95

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Antoni, F; Apati, A; Banfalvi, G; Lapis, K; Molnar, G; Schweighoffer, E; Schweighoffer, T1
Andoh, TF; Bennett, WM; Couser, WG; Johnson, RJ; Pichler, RH; Shankland, SJ; Thomas, SE1
Chalmers-Redman, RM; Rideout, HJ; Sugrue, MM; Tatton, WG; Wang, Y1
Hatake, K; Ishizaka, Y; Osawa, Y; Shimura, M; Takaku, F; Yuo, A1
Fischer, I; Murray, M; Shibata, M; Shumsky, JS; Tessler, A; Tobias, CA; Tuszynski, MH1
Bucak, YY; Çelebi, S; Erdurmus, M; Kükner, A; Terzi, EH1
Haarstad, AC; Heinrich, NA; McFadden, RA; Tomlinson, DJ1

Trials

1 trial(s) available for biotin and cyclosporine

ArticleYear
A double-blinded, randomized, controlled, crossover evaluation of a zinc methionine supplement as an adjunctive treatment for canine atopic dermatitis.
    Veterinary dermatology, 2017, Volume: 28, Issue:6

    Topics: Animals; Biotin; Cross-Over Studies; Cyclosporine; Dermatitis, Atopic; Dermatologic Agents; Dietary Supplements; Dog Diseases; Dogs; Double-Blind Method; Drug Therapy, Combination; Fatty Acids, Essential; Female; Male; Methionine; Organometallic Compounds

2017

Other Studies

9 other study(ies) available for biotin and cyclosporine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A.
    Histochemistry, 1991, Volume: 96, Issue:1

    Topics: Animals; Biotin; Cyclosporine; Deoxyuracil Nucleotides; DNA Replication; Emetine; Flow Cytometry; Humans; Male; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; T-Lymphocytes; Thymus Gland; Tumor Cells, Cultured

1991
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis.
    Kidney international, 1998, Volume: 53, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Apoptosis; Arginine; Biotin; Cyclosporine; Deoxyuracil Nucleotides; DNA Fragmentation; Enzyme Inhibitors; Fibrosis; Hydralazine; Immunosuppressive Agents; Ischemia; Kidney; Losartan; Macrophages; Male; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Staining and Labeling

1998
Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence.
    Biochemical and biophysical research communications, 1999, Jul-22, Volume: 261, Issue:1

    Topics: Animals; Apoptosis; Biotin; Cell Differentiation; Cell Membrane Permeability; Cellular Senescence; Cyclosporine; Fluorescent Dyes; Humans; Intracellular Membranes; Ion Channels; Membrane Potentials; Microscopy, Confocal; Mitochondria; Nerve Growth Factors; PC12 Cells; Permeability; Rats; Rhodamines; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Oxidative stress as a necessary factor in room temperature-induced apoptosis of HL-60 cells.
    Journal of leukocyte biology, 2000, Volume: 68, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Biotin; Caspase Inhibitors; Caspases; Cyclosporine; Cysteine Proteinase Inhibitors; Cytochrome c Group; Endopeptidases; Genes, bcl-2; HL-60 Cells; Humans; Intracellular Membranes; Mitochondria; Molecular Weight; Neoplasm Proteins; Oligopeptides; Oxidative Stress; Permeability; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Recombinant Fusion Proteins; Superoxide Dismutase; Superoxides; Temperature

2000
Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration.
    Experimental neurology, 2003, Volume: 184, Issue:1

    Topics: Animals; Atrophy; Axotomy; Biotin; Brain-Derived Neurotrophic Factor; Cell Count; Cell Size; Cell Survival; Cyclosporine; Dextrans; Female; Fibroblasts; GAP-43 Protein; Green Fluorescent Proteins; Immunohistochemistry; Immunosuppressive Agents; Luminescent Proteins; Nerve Regeneration; Neurons; Neurotrophin 3; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Red Nucleus; Spinal Cord Injuries

2003
Inhibitory effects of topical cyclosporine A 0.05% on immune-mediated corneal neovascularization in rabbits.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2013, Volume: 251, Issue:11

    Topics: Administration, Topical; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Apoptosis; Arthus Reaction; Bevacizumab; Biotin; Corneal Neovascularization; Cyclosporine; Deoxyuracil Nucleotides; Dexamethasone; Disease Models, Animal; Glucocorticoids; Immunoenzyme Techniques; Immunosuppressive Agents; In Situ Nick-End Labeling; Ophthalmic Solutions; Rabbits; Serum Albumin, Bovine

2013