Compounds > trilinolenin
Page last updated: 2024-12-11

trilinolenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

trilinolenin: RN refers to (cis,cis,cis)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1,2,3-trilinolenoylglycerol : A triglyceride formed by acylation of the three hydroxy groups of glycerol with linolenic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5462874
CHEBI ID75845
SCHEMBL ID114353
MeSH IDM0265643

Synonyms (50)

Synonym
1,2,3-tri-(9z,12z,15z-octadecatrienoyl)-glycerol
tg(18:3/18:3/18:3)
LMGL03010527
tg(18:3(9z,12z,15z)/18:3(9z,12z,15z)/18:3(9z,12z,15z))
trilinolenin
glyceryl trilinolenate, >=97% (tlc), liquid
trilinolenin c18:3
propane-1,2,3-triyl (9z,12z,15z,9'z,12'z,15'z,9''z,12''z,15''z)tris-octadeca-9,12,15-trienoate
14465-68-0
2,3-bis[[(9z,12z,15z)-octadeca-9,12,15-trienoyl]oxy]propyl (9z,12z,15z)-octadeca-9,12,15-trienoate
1,2,3-propanetriyl-9,12,15-octadecatrienoate
9,12,15-octadecatrienoic acid, 1,2,3-propanetriyl ester
1,2,3-propanetriyl linolenate
glyceryl trilinolenate
unii-oi7s0a9873
linolenic acid, 1,2,3-propanetriyl ester
einecs 238-457-5
glycerol trilinolenate
propane-1,2,3-triyl tris((9z,12z,15z)-octadeca-9,12,15-trienoate)
oi7s0a9873 ,
1,2,3-trilinolenoylglycerol
tg[18:3(omega-3)/18:3(omega-3)/18:3(omega-3)]
triacylglycerol(18:3/18:3/18:3)
triacylglycerol(54:9)
1,2,3-tri-(9z,12z,15z-octadecatrienoyl)glycerol
CHEBI:75845
1,2,3-tri-(9z,12z,15z)-octadecatrienoylglycerol
tag(54:9)
linolenoyl triglyceride
tag(18:3/18:3/18:3)
linolenin, tri-
vitamin f [who-dd]
vitamin f glycerinester
9,12,15-octadecatrienoic acid, 1,1',1''-(1,2,3-propanetriyl) ester, (9z,9'z,9''z,12z,12'z,12''z,15z,15'z,15''z)-
9,12,15-octadecatrienoic acid, 1,2,3-propanetriyl ester, (all-z)-
tri-.alpha.-linolenin
9,12,15-octadecatrienoic acid, 1,2,3-propanetriyl ester, (9z,9'z,9''z,12z,12'z,12''z,15z,15'z,15''z)-
trilinolenin [inci]
SCHEMBL114353
DTXSID6042654
UBEIMDKGOYBUKT-FLIQGJDUSA-N
J-007993
1-a-linolenoyl-2-a-linolenoyl-3-a-linolenoyl-glycerol
1-(9z,12z,15z-octadeatrienoyl)-2-(9z,12z,15z-octadeatrienoyl)-3-(9z,12z,15z-octadeatrienoyl)-glycerol
Q27145591
tri-9(z),12(z),15(z)-octadecatrienoin, trilinolenin
tri-9(z),12(z),15(z)-octadecatrienoin
1, 2, 3-trilinolenoylglycerol
PD044130
tg 18:3_18:3_18:3

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Trilinolenin (18:3; omega-3) was toxic only after prolonged incubation."( Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: the anomalous behaviour of cholesteryl linolenate.
Carpenter, KL; Hardwick, SJ; Hird, R; Law, NS; Marchant, CE; Mitchinson, MJ; Van Der Veen, C, 1997)		1.21

Bioavailability

ExcerptReferenceRelevance
" In a 2-week-long term, daily gavage study, the bioavailability of fish oil and fish oil in Cas-Glu-DGS-50 or Cas-Hylon-25 demonstrated that fish oil and Cas-Glu-DGS-50 LC n-3 PUFA were incorporated into the tissue of the small intestine and colon, whereas Cas-Hylon-25 was resistant to degradation in the small intestine."( Site specific delivery of microencapsulated fish oil to the gastrointestinal tract of the rat.
Abeywardena, MY; Augustin, MA; Head, RJ; Patten, GS; Sanguansri, L, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triacylglycerol 54:9
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z))511
De Novo Triacylglycerol Biosynthesis TG(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z))513

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's2 (16.67)29.6817
2010's5 (41.67)24.3611
2020's3 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.22 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lipoamide
Lipozyme: lipase from Rhizomucor miehei immobilized on anion exchange resin		2.0710dithiolanes;
monocarboxylic acid amide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0710aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
5,8,11,14-eicosatetraynoic acid
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).		2.3920long-chain fatty acid
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.0710catechinantioxidant;
plant metabolite
tocopherols
[no description available]		2.0710
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		2.3110octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
D-fructopyranose
[no description available]		1.9910cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
alpha-linolenic acid
linolenic acid : A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.. linolenate : A polyunsaturated fatty acid anion obtained by deprotonation of the carboxy group of either alpha- or gamma-linolenic acid.		3.4370linolenic acid;
omega-3 fatty acid		micronutrient;
mouse metabolite;
nutraceutical
trilinolein
trilinolein: RN given refers to (Z,Z)-isomer. 1,2,3-trilinoleoylglycerol : A triglyceride formed by acylation of the three hydroxy groups of glycerol with linoleic acid.		2.45201,2-diacyl-3-linoleoylglycerol;
1,3-diacyl-2-linoleoylglycerol;
linoleoyl containing 1,2,3-triacyl-sn-glycerol;
TG(18:2/18:2/18:2);
triglyceride		mouse metabolite
triolein
Triolein: (Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.. triolein : A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.		2.4520triglycerideCaenorhabditis elegans metabolite;
plant metabolite
triarachidonin
[no description available]		2.3920triacylglycerol 60:12
phytosterols
Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.		2.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1510
Alloxan Diabetes
[description not available]		01.9910