| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4. | 2.01 | 1 | 0 | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule |
octopamine
Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.. octopamine : A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates. | 2.01 | 1 | 0 | phenylethanolamines;
tyramines | neurotransmitter |
oxotremorine
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool. | 2.17 | 1 | 0 | N-alkylpyrrolidine | |
pilocarpine
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.. (+)-pilocarpine : The (+)-enantiomer of pilocarpine. | 2 | 1 | 0 | pilocarpine | antiglaucoma drug |
pyrrolidonecarboxylic acid
Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration. | 2.72 | 3 | 0 | 5-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid | algal metabolite |
enkephalin, methionine
Enkephalin, Methionine: One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN. | 1.97 | 1 | 0 | | |
proctolin
proctolin: neurotransmitter in arthropods or invertebrates | 2.94 | 4 | 0 | | |
enkephalin-met, arg(6)-phe(7)-
[no description available] | 1.97 | 1 | 0 | organic molecular entity | |
small cardioactive peptide b
small cardioactive peptide B: neuropeptide from Aplysia | 1.97 | 1 | 0 | | |
sdrnflrfamide
SDRNFLRFamide: isolated from the nervous system of the lobster Homarus americanus; exhibits FMRFamide-like immunoreactivity | 3.25 | 6 | 0 | | |
leucomyosuppressin
leucomyosuppressin: from head extracts of the cockroach Leucophaea maderae; inhibits evoked transmitter release at the mealworm neuromuscular junction | 2.02 | 1 | 0 | | |
allatostatin 1
allatostatin 1: inhibits juvenile hormone synthesis; from reproductively active females | 2.01 | 1 | 0 | | |
tetrodotoxin
Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels. | 2.17 | 1 | 0 | azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid | animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker |
fmrfamide
FMRFamide: A molluscan neuroactive peptide which induces a fast excitatory depolarizing response due to direct activation of amiloride-sensitive SODIUM CHANNELS. (From Nature 1995; 378(6558): 730-3) | 2.91 | 4 | 0 | | |
schistoflrfamide
SchistoFLRFamide: from the thoracic nervous system of the locust Schistocerca gregaria | 2.02 | 1 | 0 | | |
perisulfakinin
perisulfakinin: has sequence similarity to gastrin and cholecystokinin; isolated from American cockroach; amino acid seq. given in first source | 2.02 | 1 | 0 | | |
enkephalin-met, arg(6)-phenh2(7)-
enkephalin-Met, Arg(6)-PheNH2(7)-: heptapeptide enkephalinamide analog | 1.97 | 1 | 0 | | |
crustacean cardioactive peptide
crustacean cardioactive peptide: cardioactive neuropeptide, from the nervous system of the shore crab carcinus maenas; do not confuse with CCAP (katacalcin), a calcitonin carboxyl-terminal flanking peptide | 2.72 | 3 | 0 | | |