tnrnflrfamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

TNRNFLRFamide: SCP (small cardioactive peptide)-like peptide found in lobster neurons; exhibits FMRFamide-like immunoreactivity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	3081636
MeSH ID	M0191203

Synonyms (13)

Synonym
f1 peptide, lobster
peptide f(1), lobster
threonyl-asparaginyl-arginyl-asparaginyl-phenylalanyl-leucyl-arginyl-phenylalaninamide
113611-68-0
l-phenylalaninamide, l-threonyl-l-asparaginyl-l-arginyl-l-asparaginyl-l-phenylalanyl-l-leucyl-l-arginyl-
lobster peptide f1
thr-asn-arg-asn-phe-leu-arg-phe-nh2
(2s)-2-[[(2s)-2-[[(2s)-4-amino-2-[[(2s,3r)-2-amino-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopenta
tnrnflrfamide
DTXSID50150488
(s)-n1-((s)-1-(((s)-1-(((s)-1-(((s)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((s)-2-((s)-4-amino-2-((2s,3r)-2-amino-3-hydroxybutanamido)-4-oxobutanamido)-5-g
thr-asn-arg-asn-phe-leu-arg-phe-amide
(2s)-2-[(2s,3r)-2-amino-3-hydroxybutanamido]-n-[(1s)-4-carbamimidamido-1-{[(1s)-1-{[(1s)-1-{[(1s)-1-{[(1s)-4-carbamimidamido-1-{[(1s)-1-carbamoyl-2-phenylethyl]carbamoyl}butyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-carbamoylethyl]c

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (38.46)	18.2507
2000's	7 (53.85)	29.6817
2010's	1 (7.69)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.63 (24.57)
Research Supply Index	2.64 (2.92)
Research Growth Index	4.27 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.63)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	2.01	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
octopamine Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.. octopamine : A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.	2.01	1	phenylethanolamines; tyramines	neurotransmitter
oxotremorine Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.	2.17	1	N-alkylpyrrolidine
pilocarpine Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.. (+)-pilocarpine : The (+)-enantiomer of pilocarpine.	2	1	pilocarpine	antiglaucoma drug
pyrrolidonecarboxylic acid Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.	2.72	3	5-oxoproline; L-proline derivative; non-proteinogenic L-alpha-amino acid	algal metabolite
enkephalin, methionine Enkephalin, Methionine: One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	1.97	1
proctolin proctolin: neurotransmitter in arthropods or invertebrates	2.94	4
enkephalin-met, arg(6)-phe(7)- [no description available]	1.97	1	organic molecular entity
small cardioactive peptide b small cardioactive peptide B: neuropeptide from Aplysia	1.97	1
sdrnflrfamide SDRNFLRFamide: isolated from the nervous system of the lobster Homarus americanus; exhibits FMRFamide-like immunoreactivity	3.25	6
leucomyosuppressin leucomyosuppressin: from head extracts of the cockroach Leucophaea maderae; inhibits evoked transmitter release at the mealworm neuromuscular junction	2.02	1
allatostatin 1 allatostatin 1: inhibits juvenile hormone synthesis; from reproductively active females	2.01	1
tetrodotoxin Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.	2.17	1	azatetracycloalkane; oxatetracycloalkane; quinazoline alkaloid	animal metabolite; bacterial metabolite; marine metabolite; neurotoxin; voltage-gated sodium channel blocker
fmrfamide FMRFamide: A molluscan neuroactive peptide which induces a fast excitatory depolarizing response due to direct activation of amiloride-sensitive SODIUM CHANNELS. (From Nature 1995; 378(6558): 730-3)	2.91	4
schistoflrfamide SchistoFLRFamide: from the thoracic nervous system of the locust Schistocerca gregaria	2.02	1
perisulfakinin perisulfakinin: has sequence similarity to gastrin and cholecystokinin; isolated from American cockroach; amino acid seq. given in first source	2.02	1
enkephalin-met, arg(6)-phenh2(7)- enkephalin-Met, Arg(6)-PheNH2(7)-: heptapeptide enkephalinamide analog	1.97	1
crustacean cardioactive peptide crustacean cardioactive peptide: cardioactive neuropeptide, from the nervous system of the shore crab carcinus maenas; do not confuse with CCAP (katacalcin), a calcitonin carboxyl-terminal flanking peptide	2.72	3

Condition	Indicated	Relationship Strength	Studies	Trials
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	0	2.92	4	0

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