Compounds > ropizine
Page last updated: 2024-12-11

ropizine

Description

ropizine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9568666
CHEMBL ID2107093
SCHEMBL ID635135
MeSH IDM0048624

Synonyms (33)

Synonym
1-piperazinamine, 4-(diphenylmethyl)-n-((6-methyl-2-pyridinyl)methylene)-
1-(diphenylmethyl)-4-[[(6-methyl-2-pyridyl)methylene]amino]piperazine
1-piperazinamine, 4-(diphenylmethyl)-n-[(6-methyl-2-pyridinyl)methylene]-
sc-13504
nsc300584
nsc-300584
1-diphenylmethyl-4-[(6-methyl-2-pyridyl)methyleneamino]piperazine
3601-19-2
piperazine, 1-(diphenylmethyl)-4-[[(6-methyl-2-pyridyl)methylene]amino]-
sc 13504
ropizine
unii-q5128gw9d4
nsc 300584
q5128gw9d4 ,
ropizinum [inn-latin]
1-(diphenylmethyl)-4-((6-methyl-2-pyridyl)methylenamino)piperazin
piperazine, 1-(diphenylmethyl)-4-(((6-methyl-2-pyridyl)methylene)amino)-
ropizina [inn-spanish]
ropizinum
ropizine [usan:inn]
1-(diphenylmethyl)-4-(((6-methyl-2-pyridyl)methylene)amino)piperazine
ropizina
1-benzyl-4-(6-methyl-2-pyridyl)methylenamino)piperazin
CHEMBL2107093
ropizine [inn]
ropizine [usan]
SCHEMBL635135
DTXSID60189567
n-(4-benzhydryl-1-piperazinyl)-n-[(e)-(6-methyl-2-pyridinyl)methylidene]amine
(e)-n-(4-benzhydrylpiperazin-1-yl)-1-(6-methylpyridin-2-yl)methanimine
HY-123229
CS-0082158
AKOS040747421
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (66.67)18.7374
1990's4 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenytoin
[no description available]		2.6530imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		2.6430barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
diphenhydramine hydrochloride
Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.. diphenhydramine hydrochloride : The hydrochloride salt of diphenhydramine.		2.3820hydrochloride;
organoammonium salt		anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative
pentazocine
Pentazocine: The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)		2.6730benzazocine
preclamol
preclamol: centrally acting dopamine receptor agonist with selectivity for autoreceptors		2.8940
levorphanol
Levorphanol: A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.		3.0750morphinane alkaloid
dextromethorphan
Dextromethorphan: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.. dextromethorphan : A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.		3.36706-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthreneantitussive;
environmental contaminant;
neurotoxin;
NMDA receptor antagonist;
oneirogen;
prodrug;
xenobiotic
piperidines
Piperidines: A family of hexahydropyridines.		2.8940
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9510
Canine Diseases
[description not available]		01.9510
Aura
[description not available]		01.9510
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)		01.9510
Absence Seizure
[description not available]		02.3620
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.3620
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