Compounds > narbomycin
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narbomycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

narbomycin: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

narbomycin : A macrolide antibiotic that is narbonolide having a 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residue attached at position 6. It is biosynthesised by Streptomyces venezuelae. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5282036
CHEMBL ID106096
CHEBI ID29649
SCHEMBL ID691770
MeSH IDM0056015

Synonyms (23)

Synonym
12-deoxypicromycin
narbomycin
C11998 ,
6036-25-5
CHEMBL106096 ,
chebi:29649 ,
(3r,5r,6s,7s,9r,11e,13r,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-3,5,7,9,13-pentamethyl-1-oxacyclotetradec-11-ene-2,4,10-trione
AC1NQZE9 ,
unii-024664144v
024664144v ,
(3r,5r,6s,7s,9r,11e,13r,14r)-14-ethyl-3,5,7,9,13-pentamethyl-2,4,10-trioxooxacyclotetradec-11-en-6-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranoside
SCHEMBL691770
narbomycin [mi]
(+)-narbomycin
oxacyclotetradec-11-ene-2,4,10-trione, 14-ethyl-3,5,7,9,13-pentamethyl-6-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylo-hexopyranosyl)oxy)-, (3r,5r,6s,7s,9r,11e,13r,14r)-
antibiotic b-62169b
(10e)-3-de((2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribohexopyranosyl)oxy)-10,11-didehydro-10-demethyl-6,11,12-trideoxy-3-oxoerythromycin
erythromycin, 3-de((2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy)-10,11-didehydro-10-demethyl-6,11,12-trideoxy-3-oxo-, (10e)-
picromycin, 12-deoxy-
surecn691770
(3r,5r,6s,7s,9r,11e,13r,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-ethyl-3,5,7,9,13-pentamethyl-1-oxacyclotetradec-11-ene-2,4,10-trione
Q27104078
DTXSID301318396

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
macrolide antibioticA macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
enoneAn alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID18087Kinetic behavior of the enzyme (PicK/6-His) was evaluated1998Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae.
AID229375Ratio of kcat to Km was evaluated.1998Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae.
AID17470Catalytic constant expressed as Kinetic behavior of enzyme (PicK/6-His)1998Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae.
AID18293Michaelis behavior of the enzyme (PicK/6-His)1998Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's3 (27.27)18.2507
2000's4 (36.36)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.92 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.77 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		1.9910amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
desosamine
desosamine: RN given for (D-xylo)-isomer; structure in first source		2.7530amino sugar
10-deoxymethynolide
10-deoxymethynolide: structure given in first source; parent aglycone of methymycin and neomethymycin. 10-deoxymethynolide : A macrolide that consists of oxacyclododec-9-ene-2,8-dione bearing four methyl substituents at positions 3, 5, 7 and 11 as well as a hydroxy group at position 4 and an ethyl substituent at position 12. The aglycone of the macrolide antibiotic 10-deoxymethymycin.		210macrolidemetabolite
neomethymycin
neomethymycin: structure. neomethymycin : A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae.		2.4320enone;
macrolide antibiotic;
monosaccharide derivative		bacterial metabolite
methymycin
methymycin: structure. methymycin : A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae.		2.4320enone;
macrolide antibiotic;
monosaccharide derivative		bacterial metabolite
picromycin
picromycin: structure. pikromycin : A macrolide antibiotic that is biosynthesised by Streptomyces venezuelae.		8.1250enone;
macrolide antibiotic;
monosaccharide derivative		bacterial metabolite
ConditionIndicatedRelationship StrengthStudiesTrials