n-methyl-4-aminoazobenzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-methyl-4-aminoazobenzene: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	12137
SCHEMBL ID	5982612
MeSH ID	M0046577

Synonyms (33)

Synonym
n-methyl-4-(phenylazo)benzenamine
n-methyl-4-aminoazobenzene
n-methyl-p-(phenylazo)aniline
aniline, n-methyl-p-(phenylazo)-
p-monomethylaminoazobenzene
4-(methylamino)azobenzene
ccris 382
4-monomethylaminoazobenzene
benzenamine, n-methyl-4-(phenylazo)-
n-methyl-p-aminoazobenzene
p-n-methylaminoazobenzene
MAB ,
n-methyl-4-phenyldiazenylaniline
M0143
621-90-9
AE-562/43459099
n-methyl-n-[4-(phenyldiazenyl)phenyl]amine
unii-44n974bfdi
44n974bfdi ,
SCHEMBL5982612
monomethylaminoazobenzene, 4-
n-methyl-4-[phenyldiazenyl]aniline #
p-(phenylazo)-n-methylaniline
DKOXITJAUZNAPK-FOCLMDBBSA-N
mfcd00059198
4-methylaminoazobenzene
(e)-n-methyl-4-(phenyldiazenyl)aniline
Q27889325
FT-0704252
n-methyl-4-(phenyldiazenyl)aniline
n-methyl-4-[(e)-2-phenyldiazen-1-yl]aniline
D91285
DTXSID201023342

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" The levels of total MAB-DNA adducts in the liver were 2-10 times greater than in the kidney or spleen and appeared to increase 2- to 3-fold over the dosing period."	( Characterization and properties of the DNA adducts formed from N-methyl-4-aminoazobenzene in rats during a carcinogenic treatment regimen. Baetcke, KP; Dooley, KL; Kadlubar, FF; Miller, DW; Tullis, DL, 1987)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	16 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.45

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.45 (24.57)
Research Supply Index	3.00 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.45)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.26%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (94.74%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
3-methylcholanthrene Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.	1.96	1	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent
phenacetin Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione	3.05	1	acetamides; aromatic ether	cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.95	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
2-acetylaminofluorene 2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.	3.05	1	2-acetamidofluorenes	antimitotic; carcinogenic agent; epitope; mutagen
methyldimethylaminoazobenzene Methyldimethylaminoazobenzene: A very potent liver carcinogen.. 3-methyl-4'-dimethylaminoazobenzene : A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. It is a potent liver carcinogen.	1.96	1
4-nitroquinoline-1-oxide 4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.	3.05	1	C-nitro compound; quinoline N-oxide	carcinogenic agent
p-aminoazobenzene p-Aminoazobenzene: Used in the form of its salts as a dye and as an intermediate in manufacture of Acid Yellow, diazo dyes, and indulines.. 4-(phenylazo)aniline : Azobenzene substituted at one of the 4-positions by an amino group. It has a role as a dye and an allergen.	5.2	16
p-dimethylaminoazobenzene p-Dimethylaminoazobenzene: A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound may reasonably be anticipated to be a carcinogen. (Merck, 11th ed)	2.87	4	azobenzenes
2-naphthylamine 2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2.	3.05	1	naphthylamine	carcinogenic agent
4-biphenylamine 4-biphenylamine: used in detection of sulfates, & as a carcinogen in cancer research; RN given refers to parent cpd; structure. biphenyl-4-amine : An aminobiphenyl that is biphenyl substituted by an amino group at position 4.	1.97	1	aminobiphenyl	carcinogenic agent
1-naphthylamine 1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.. naphthylamine : A primary arylamine that is naphthalene substituted by an amino group at unspecified position.. 1-naphthylamine : A naphthylamine that is naphthalene substituted by an amino group at position 1.	3.05	1	naphthylamine	human xenobiotic metabolite
3'-methyl-4-methylaminoazobenzene [no description available]	1.96	1
n-benzoyloxy-n-methyl-4-aminoazobenzene [no description available]	2.65	3
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	1.95	1	cysteinium	fundamental metabolite
deoxyguanosine [no description available]	1.97	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.95	1
Cancer of Liver [description not available]	1.95	1
Experimental Hepatoma [description not available]	2.36	2
Experimental Neoplasms [description not available]	1.95	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.95	1

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