Compounds > mixidine
Page last updated: 2024-12-06

mixidine

Description

mixidine: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID34003
CHEMBL ID75797
SCHEMBL ID122203
SCHEMBL ID10757630
MeSH IDM0068370

Synonyms (25)

Synonym
CHEMBL75797
27737-38-8
D05063
mixidine (usan/inn)
mcn-1589
mixidine
n-[2-(3,4-dimethoxyphenyl)ethyl]-1-methylpyrrolidin-2-imine
3,4-dimethoxy-n-(1-methyl-2-pyrrolidinylidene)benzeneethanamine
mixidina [inn-spanish]
mixidina
mixidine [usan:inn]
mixidinum
2-((3,4-dimethoxyphenethyl)imino)-1-methylpyrrolidine
mcn 1589
mixidinum [inn-latin]
benzeneethanamine, 3,4-dimethoxy-n-(1-methyl-2-pyrrolidinylidene)-
835xo5w69h ,
unii-835xo5w69h
SCHEMBL122203
mixidine [usan]
mixidine [inn]
2-[(3,4-dimethoxyphenethyl)imino]-1-methylpyrrolidine
SCHEMBL10757630
DTXSID00865393
Q27269407

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID58437Change in heart rate at the above D50 dose in conscious dogs1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62116Evaluated for the heart rate at dose 1.0 mg/kg in 4 animals by poldine tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62240Evaluated for the heart rate at dose 2.5 mg/kg in 6 animals by aminophylline-induced sinus tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62243Evaluated for the heart rate at dose 5.0 mg/kg in 4 animals by glucagon-induced tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID60470Dose required to achieve 50 % of maximal cardiac slowing in triazine tachycardia test in conscious dog1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62112Evaluated for the heart rate at dose 0.5 mg/kg in 4 animals by poldine tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID59380Evaluated for the myocardial depression rating which is barely observable for the given compound in Conscious Dog1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62237Evaluated for the heart rate at dose 2.5 mg/kg in 4 animals by glucagon-induced tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID58751Relative activity (fraction of the most active compound 24) was determined1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID58438Percent decrease from initial heart rate (percent delta HR50/HR0 x 100) in dogs1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62244Evaluated for the heart rate at dose 5.0 mg/kg in 6 animals by aminophylline-induced sinus tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62238Evaluated for the heart rate at dose 2.5 mg/kg in 4 animals by poldine tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID62118Evaluated for the heart rate at dose 1.0 mg/kg in 6 animals by aminophylline-induced sinus tachycardia test1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
AID55922Cardiac slowing index was measured for potency and efficacy1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.27 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (20.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bepridil
Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.. bepridil : A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.		1.9610pyrrolidines;
tertiary amine		anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		1.9510catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
propranolol
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.		1.9610naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
aminophylline
Aminophylline: A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.. aminophylline : A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.		1.9510mixturebronchodilator agent;
cardiotonic drug
glucagon
Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.		1.9510peptide hormone
cardiovascular agents
Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.		2.3620
ConditionIndicatedRelationship StrengthStudiesTrials
Angor Pectoris
[description not available]		01.9610
Tachyarrhythmia
[description not available]		01.9610
Angina Pectoris
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.		01.9610
Tachycardia
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.		01.9610
Coronary Heart Disease
[description not available]		01.9510
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.		01.9510
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