Page last updated: 2024-09-04

mexiprostil and alprostadil

mexiprostil has been researched along with alprostadil in 12 studies

Compound Research Comparison

Studies
(mexiprostil)
Trials
(mexiprostil)
Recent Studies (post-2010)
(mexiprostil)
Studies
(alprostadil)
Trials
(alprostadil)
Recent Studies (post-2010) (alprostadil)
13407,136864761

Protein Interaction Comparison

ProteinTaxonomymexiprostil (IC50)alprostadil (IC50)
Multidrug resistance-associated protein 4Homo sapiens (human)2.3
Solute carrier organic anion transporter family member 2B1Rattus norvegicus (Norway rat)0.0358

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-199011 (91.67)18.7374
1990's1 (8.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hall, TJ; Heckel, C1
Dammann, HG; Leucht, U; Müller, P; Simon, B1
Ciabatti, R; Padova, G; Pelizzi, G; Tarzia, G1
Bianchi Porro, G; Fuccella, L; Lazzaroni, M; Petrillo, M; Sassella, D1
Dammann, HG; Müller, P; Simon, B1
Battaglia, F; Cellentani, M; Ciabatti, R; Depaoli, A; Galliani, G; Guzzi, U; Padova, G; Schiatti, P; Spina, G1
Coruzzi, G; Poli, E1
Gallico, L; Glässer, A; Schiatti, P; Selva, D; Spina, G1
Bertaccini, G; Scarpignato, C; Signorini, GC; Spina, G1
Ciabatti, R; Colombo, G; Galliani, G; Glässer, A; Guzzi, U; Luzzani, F1
Adami, M; Bertaccini, G; Coruzzi, G; Glässer, A; Poli, E1
Bardoni, A; Castellani, AA; Glässer, A; Pallavicini, G; Profumo, A; Schiatti, P1

Trials

3 trial(s) available for mexiprostil and alprostadil

ArticleYear
An alprostadil analogue and human gastric secretion. A double-blind placebo-controlled study of the effects of a capsule and tablet formulation.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:7

    Topics: Adult; Alprostadil; Anti-Ulcer Agents; Capsules; Double-Blind Method; Gastric Acid; Gastric Mucosa; Humans; Male; Pentagastrin; Placebos; Prostaglandins E, Synthetic; Tablets; Time Factors

1989
Gastric antisecretory and cytoprotective activity of MDL 646, a 16-methyl-16-methoxy prostaglandin E1 analog in man.
    Hepato-gastroenterology, 1987, Volume: 34, Issue:3

    Topics: Administration, Oral; Adult; Aged; Alprostadil; Anti-Ulcer Agents; Gastric Acid; Gastric Acidity Determination; Gastric Mucosa; Humans; Male; Middle Aged; Prostaglandins E, Synthetic

1987
An alprostadil analogue and human gastric secretion. A double-blind placebo-controlled study of the effects of a tablet and lyovial formulation.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:8

    Topics: Adult; Alprostadil; Anti-Ulcer Agents; Double-Blind Method; Gastric Acid; Gastric Mucosa; Humans; Male; Pentagastrin; Prostaglandins E, Synthetic; Tablets

1987

Other Studies

9 other study(ies) available for mexiprostil and alprostadil

ArticleYear
Lack of effect of verapamil and MDL 646, a cytoprotective PGE1 analogue on cyclosporin A nephrotoxicity in vitro.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 67, Issue:2

    Topics: Alprostadil; Animals; Anti-Ulcer Agents; Cattle; Cell Division; Cells, Cultured; Cyclosporins; Kidney Diseases; Prostaglandins E, Synthetic; Swine; Verapamil

1990
X-ray structure determination of mexiprostil, a new gastroprotective 16-methoxy-16-methyl-PGE1 analogue.
    Prostaglandins, 1988, Volume: 35, Issue:4

    Topics: Alprostadil; Anti-Ulcer Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Prostaglandins E, Synthetic; X-Ray Diffraction

1988
Structure-activity studies of 16-methoxy-16-methyl prostaglandins.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:10

    Topics: Alprostadil; Antidiarrheals; Fertility; Gastric Acid; Molecular Conformation; Prostaglandins E, Synthetic; Prostaglandins F, Synthetic; Structure-Activity Relationship

1986
[Action of a new synthetic prostaglandin on gastroesophageal motility of the rat].
    Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma, 1982, Volume: 53, Issue:3

    Topics: Alprostadil; Animals; Gastrointestinal Motility; In Vitro Techniques; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Stimulation, Chemical

1982
MDL-646, a new synthetic E1-prostaglandin with local protective effects on the gastric mucosa.
    Prostaglandins, 1984, Volume: 28, Issue:2

    Topics: Alprostadil; Animals; Anti-Ulcer Agents; Blood Pressure; Ethanol; Gastric Juice; Gastric Mucosa; Heart Rate; Indomethacin; Male; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Stomach Ulcer

1984
Action of MDL 646, a new synthetic prostaglandin, on gastric acid secretion of some experimental animals.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 39, Issue:2

    Topics: Alprostadil; Animals; Bethanechol Compounds; Cats; Chemical Phenomena; Chemistry; Depression, Chemical; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Gastric Acid; Gastric Acidity Determination; Histamine; Pentagastrin; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Species Specificity

1983
Studies on the luteolytic activity of MDL-646, a new gastroprotective PGE1 analogue, in the hamster.
    Prostaglandins, 1984, Volume: 27, Issue:4

    Topics: Abortion, Spontaneous; Alprostadil; Animals; Anti-Ulcer Agents; Corpus Luteum; Cricetinae; Dinoprostone; Female; Mesocricetus; Pregnancy; Progesterone; Prostaglandins E; Prostaglandins E, Synthetic; Structure-Activity Relationship

1984
Effect of MDL 646, a new synthetic prostaglandin, on gastroesophageal motility of the rat.
    Il Farmaco; edizione scientifica, 1983, Volume: 38, Issue:2

    Topics: Alprostadil; Animals; Esophagogastric Junction; Esophagus; Female; Gastrointestinal Motility; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Stomach

1983
Protection of rat gastric mucosa against ethanol injury by the new synthetic prostaglandin MDL 646.
    Experientia, 1984, Apr-15, Volume: 40, Issue:4

    Topics: Alprostadil; Animals; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Glycoproteins; Male; Necrosis; Prostaglandins E, Synthetic; Proteins; Rats; Rats, Inbred Strains; Stomach Diseases

1984