Compounds > mexacarbate
Page last updated: 2024-12-05

mexacarbate

Description

mexacarbate: insecticide & acaricide; minor descriptor (75-82); online & Index Medicus search INSECTICIDES, CARBAMATE (75-82) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9414
CHEMBL ID454804
CHEBI ID82092
SCHEMBL ID121459
MeSH IDM0262440

Synonyms (71)

Synonym
phenol, 4-(dimethylamino)-3,5-dimethyl-, methylcarbamate (ester)
mexacarbate
315-18-4
4-(dimethylamino)-3,5-dimethylphenyl methylcarbamate
carbamate, 4-dimethylamino-3,5-xylyl n-methyl-
einecs 206-249-3
nci-c00544
4-(dimethylamino)-3,5-xylyl methylcarbamate
methyl-4-dimethylamino-3,5-xylyl carbamate
4-(dimethylamine)-3,5-xylyl n-methylcarbamate
oms 639
caswell no. 579b
zectran
ai3-25766
4-(dimethylamino)-3,5-dimethylphenol methylcarbamate (ester)
carbamic acid, methyl-, 4-(dimethylamino)-3,5-dimethylphenyl ester
mexicarbate
methyl-4-dimethylamino-3,5-xylyl ester of carbamic acid
dowco 139
zectrane
hsdb 1042
methylcarbamic acid, 4-(dimethylamino)-3,5-xylyl ester
mexacarbate [ansi]
brn 2216978
4-(dimethylamino)-3,5-dimethylphenyl n-methylcarbamate
3,5-dimethyl-4-(dimethylamino)phenyl methylcarbamate
zectane
3,5-xylenol, 4-(dimethylamino)-, methylcarbamate
4-dimethylamino-3,5-xylyl n-methylcarbamate
4-dimethylamino-3,5-xylyl methylcarbamate
epa pesticide chemical code 044201
zextran
ent 25766
ccris 411
carbamic acid, methyl-, 4-(dimethylamino)-3,5-xylyl ester
4-dimethylamino-3,5-xylyl-n-methylcarbamate
oms-47
4-(n,n-dimethylamino)-3,5-xylyl n-methylcarbamate
4-(dimethylamino)-3,5-xylenol, methylcarbamate (ester)
carbamic acid, methyl-, 4-dimethylamino-3,5-xylyl ester
MAZ ,
[4-(dimethylamino)-3,5-dimethylphenyl] n-methylcarbamate
chebi:82092 ,
CHEMBL454804
NCGC00248781-01
C18952
dtxcid50893
cas-315-18-4
tox21_200649
dtxsid7020893 ,
NCGC00258203-01
mexacarbate [ansi:iso]
unii-ztm4ipv8g8
ztm4ipv8g8 ,
mexacarbate [mi]
mexacarbate [iso]
zectran [iarc]
phenol, 4-(dimethylamino)-3,5-dimethyl-, 1-(n-methylcarbamate)
methylcarbamic acid 4-(dimethylamino)-3,5-xylyl ester
mexacarbate [hsdb]
SCHEMBL121459
4-(dimethylamino)-3,5-xylenol, methylcarbamate
4-(dimethylamino)-3,5-dimethylphenyl methylcarbamate #
ent 25,766
phenol, 4-(dimethylamino)-3,5-dimethyl-, methylcarbamate
4-(dimethylamino)-3,5-dimethylphenol methylcarbamate
4-dimethylamino-3,5-dimethylphenyl n-methylcarbamate
carbamic acid, 3,5-dimethyl-4-dimethylaminophenyl ester, n-methyl
mexacarbate, pestanal(r), analytical standard
pesticide9_mexacarbate_c12h18n2o2_4-(dimethylamino)-3,5-dimethylphenyl methylcarbamate
Q6825702

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"Zectran (4-dimethylamino-3,5-xylyl N-methyl-carbamate), a carbamate insecticide (active ingredient [AI] mexacarbate), was aerially applied to two 300 ha plots of coniferous forest at dosage rates of 70 and 140 g AI/ha, respectively."( An interlaboratory comparison of data on brain cholinesterase activity in forest songbirds exposed to aerial application of Zectran.
Busby, DG; Fleming, RA; Holmes, SB, 1992)		0.5
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
acetylcholinesteraseHomo sapiens (human)Potency4.54910.002541.796015,848.9004AID1347395; AID1347397; AID1347398; AID1347399
GLI family zinc finger 3Homo sapiens (human)Potency27.87220.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency57.18510.000221.22318,912.5098AID1259381; AID743042; AID743054
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency34.37620.000657.913322,387.1992AID1259377
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency18.48760.001022.650876.6163AID1224838; AID1224839; AID1224893
retinoid X nuclear receptor alphaHomo sapiens (human)Potency42.45170.000817.505159.3239AID1159527; AID1159531
pregnane X nuclear receptorHomo sapiens (human)Potency30.63790.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency5.49810.000229.305416,493.5996AID743075
aryl hydrocarbon receptorHomo sapiens (human)Potency68.58960.000723.06741,258.9301AID743085; AID743122
thyroid stimulating hormone receptorHomo sapiens (human)Potency60.01230.001628.015177.1139AID1224843; AID1224895
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency64.75280.000627.21521,122.0200AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID399286In vivo inhibition of acetylcholinesterase from nerve tissue of Lymnaea acuminata at 2.5 mg/L relative to control
AID399292Inhibition of acetylcholinesterase from nerve tissue of Lymnaea acuminata at 1 ug w/v relative to control
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (66.67)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.86 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		3.2160amino-acid anion
cypermethrin
cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.		6.9810aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound		agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide
phorate
Phorate: A cholinesterase inhibitor that is used as an insecticide.. phosphatidylcholine O-34:2 : A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 2 double bonds.		6.9810organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
carbaryl
Carbaryl: A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.. carbaryl : A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.		6.9610carbamate ester;
naphthalenes		acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant growth retardant
ronnel
ronnel: FENCHLORPHOS was heading 1972-95 (Prov 1972-73); RONNEL was see FENCHLORPHOS 1975-95; use FENCHLORPHOS (NM) to search FENCHLORPHOS 1972-95		1.9410organic thiophosphate
methyl carbamate
methyl carbamate : A carbamate ester resulting from the formal condensation of the carboxy group of carbamic acid with methanol.		1.9410carbamate ester
acetylthiocholine
Acetylthiocholine: An agent used as a substrate in assays for cholinesterases, especially to discriminate among enzyme types.		1.9810
aldicarb
Aldicarb: Carbamate derivative used as an insecticide, acaricide, and nematocide.. aldicarb : The oxime carbamate resulting from the addition of 2-methyl-2-(methylsulfanyl)propanaldoxime to methyl isocyanate. A member of the class of oxime carbamate insecticides, aldicarb is a mixture of E and Z isomers; it is not known which isomer is more active.		6.9610
pyrethrins
[no description available]		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
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