Page last updated: 2024-11-12
machilin a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
machilin A: stimulates osteoblast differentiation; isolated from Myristica fragrans; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 10359012 |
| CHEMBL ID | 261367 |
| MeSH ID | M0534148 |
Synonyms (6)
| Synonym |
|---|
| CHEMBL261367 |
| machilin a |
| 5-[(2s,3r)-4-(1,3-benzodioxol-5-yl)-2,3-dimethyl-butyl]-1,3-benzodioxole |
| 5-[(2r,3s)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-1,3-benzodioxole |
| 5,5'-[(2r,3s)-2,3-dimethylbutane-1,4-diyl]bis(2h-1,3-benzodioxole) |
| 9g9 , |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (11)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID433939 | Cytotoxicity against human A375 cells assessed as inhibition of DNA synthesis in at 50 uM | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. |
| AID433937 | Cytotoxicity against human HepG2 cells after 5 days by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. |
| AID433940 | Cytotoxicity against human A375 cells assessed as inhibition of RNA synthesis at 50 uM | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. |
| AID433938 | Cytotoxicity against human A375 cells after 5 days by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. |
| AID323986 | Proliferative potency in human MCF7 BUS cells assessed as induction of maximal cell proliferation relative to 17-beta estradiol | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Structure and estrogenic activity of new lignans from Iryanthera lancifolia. |
| AID323983 | Estrogenic potency in human MCF7 BUS cells assessed as drug level inducing maximal cell proliferation | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Structure and estrogenic activity of new lignans from Iryanthera lancifolia. |
| AID323985 | Proliferative effect in human MCF7 BUS cells assessed as increase in cell number relative to 17-beta estradiol | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Structure and estrogenic activity of new lignans from Iryanthera lancifolia. |
| AID323984 | Proliferative effect in human MCF7 BUS cells assessed as ratio of increase in cell number in drug treated to control | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6 | Structure and estrogenic activity of new lignans from Iryanthera lancifolia. |
| AID433936 | Cytotoxicity against human MCF7 cells after 5 days by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. |
| AID433941 | Cytotoxicity against human A375 cells assessed as inhibition of protein synthesis at 50 uM | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. |
| AID433935 | Cytotoxicity against human HT-29 cells after 5 days by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.63
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.63) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||