Lucidin is a natural product isolated from the medicinal plant *Hypericum perforatum* (St. John's wort). It exhibits potent antibacterial and antiviral activities, specifically against Gram-positive bacteria and herpes simplex virus. Lucidin is known to inhibit bacterial cell wall synthesis and viral DNA replication. It has also shown promise as an anti-inflammatory agent. Researchers are studying lucidin to explore its potential therapeutic applications in treating infections and inflammatory diseases. Its unique structure and biological activity make it a promising lead compound for drug development.'
lucidin: from Rubiatinctorum L. root [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10163 |
| CHEBI ID | 6554 |
| SCHEMBL ID | 705681 |
| MeSH ID | M0117774 |
| Synonym |
|---|
| hsdb 7146 |
| lucidin (quinone) |
| anthraquinone, 1,3-dihydroxy-2-(hydroxymethyl)- |
| 1,3-dihydroxy-2-(hydroxymethyl)anthraquinone |
| 1,3-dihydroxy-2-hydroxymethylanthraquinoline |
| 9,10-anthracenedione, 1,3-dihydroxy-2-(hydroxymethyl)- |
| nsc 30546 |
| anthraquinone, 1,3-dihydroxy-2-hydroxymethyl- |
| ccris 1642 |
| brn 1888954 |
| henine |
| nsc-30546 |
| nsc30546 |
| wln: l c666 bv ivj dq e1q fq |
| 9, 1,3-dihydroxy-2-(hydroxymethyl)- |
| anthraquinone,3-dihydroxy-2-(hydroxymethyl)- |
| 478-08-0 |
| lucidin |
| 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione |
| unii-60q5564o9d |
| 4-08-00-03576 (beilstein handbook reference) |
| 60q5564o9d , |
| dihydroxy-2-(hydroxymethyl)anthraquinone, 1,3- |
| lucidin [hsdb] |
| FD5009 |
| CS-1555 |
| HY-15733 |
| SCHEMBL705681 |
| CHEBI:6554 |
| mfcd01664482 |
| DTXSID10197278 |
| AKOS027328039 |
| 1,3-dihydroxy-2-hydroxymethyl-9,10-anthracenedione |
| lucidin (nsc 30546) |
| FT-0744982 |
| BS-16831 |
| Q27107238 |
| nsc 30546;henine;1,3-dihydroxy-2-(hydroxymethyl)anthraquinone |
| BCP31463 |
| A914594 |
| 1,3-dihydroxy-2-hydroxymethylanthracene-9,10-dione |
| 1,3-dihydroxy-2-(hydroxymethyl)-9,10-dihydroanthracene-9,10-dione |
Lucidin is a genotoxic and mutagenic hydroxyanthraquinone metabolite. It originates from the roots of Rubia tinctorum L.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Lucidin is a genotoxic and mutagenic hydroxyanthraquinone metabolite, which originates from the roots of Rubia tinctorum L. " | ( Synthesis and polymerase-mediated bypass studies of the N2-deoxyguanosine DNA damage caused by a lucidin analogue. Ghodke, PP; Harikrishna, S; Pradeepkumar, PI, 2015) | 2.08 |
| Class | Description |
|---|---|
| dihydroxyanthraquinone | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (37.47) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||