Compounds > indenestrol b
Page last updated: 2024-12-07

indenestrol b

Indenestrol b is a non-steroidal synthetic estrogen. It was first synthesized in 1951 and was initially marketed as a treatment for menopausal symptoms. However, it was withdrawn from the market due to concerns about its safety. Indenestrol b has been shown to have estrogenic activity in animal studies, but its effects in humans are not well understood. The compound is currently being studied for its potential therapeutic uses, such as in the treatment of breast cancer. It is being investigated for its potential as a selective estrogen receptor modulator (SERM). SERMs are a class of drugs that can act as agonists or antagonists of estrogen receptors, depending on the target tissue. Indenestrol b is also being studied for its potential to prevent osteoporosis.'

Cross-References

ID SourceID
PubMed CID114716
MeSH IDM0137158

Synonyms (15)

Synonym
indenestrol b
1h-inden-5-ol, 1-ethyl-2-(4-hydroxyphenyl)-3-methyl-
ccris 7205
1-ethyl-2-(4-hydroxyphenyl)-3-methyl-1h-inden-5-ol
indenoestrol b
38028-27-2
133830-97-4
unii-jhx6qh0hf6
jhx6qh0hf6 ,
(+/-)-indenestrol b
indenestrol b, (+/-)-
(rs)-indenestrol b
1-ethyl-2-(4-hydroxyphenyl)-3-methylinden-5-ol
Q27281510
DTXSID301030716
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.05 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indenestrol
[no description available]		3.2360
equilin
Equilin: An estrogenic steroid produced by HORSES. It has a total of four double bonds in the A- and B-ring. High concentration of euilin is found in the URINE of pregnant mares.		1.971017-oxo steroid;
3-hydroxy steroid
diethylstilbestrol
Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed). diethylstilbestrol : An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.		2.3720olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
zearalenone
Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.		1.9710macrolide;
resorcinols		fungal metabolite;
mycoestrogen
daidzein
[no description available]		1.97107-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite
phytoestrogens
Phytoestrogens: Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Aneuploid
[description not available]		01.9810
Abnormalities, Autosome
[description not available]		01.9810
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