hexahydrodifenidol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

hexahydrodifenidol: muscarinic antagonist; RN from Toxlit [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	124226
MeSH ID	M0168511

Synonyms (13)

Synonym
gtpl322
L023948
hexahydrodifenidol
1-cyclohexyl-1-phenyl-4-piperidin-1-ylbutan-1-ol
cas_113010-69-8
bdbm81960
hexahydrodiphenidol
hexahydro-diphenidol
113010-69-8
piperidinebutanol, alpha-cyclohexyl-alpha-phenyl-
1-cyclohexyl-1-phenyl-4-(piperidin-1-yl)butan-1-ol
DTXSID60920977
Q27077979

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID1345343	Human M3 receptor (Acetylcholine receptors (muscarinic))	1989	Molecular pharmacology, Apr, Volume: 35, Issue:4	Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
AID1345543	Human M5 receptor (Acetylcholine receptors (muscarinic))	1989	Molecular pharmacology, Apr, Volume: 35, Issue:4	Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
AID1345326	Human M2 receptor (Acetylcholine receptors (muscarinic))	1989	Molecular pharmacology, Apr, Volume: 35, Issue:4	Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
AID1345189	Rat M1 receptor (Acetylcholine receptors (muscarinic))	1989	Molecular pharmacology, Apr, Volume: 35, Issue:4	Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
AID1345465	Human M4 receptor (Acetylcholine receptors (muscarinic))	1989	Molecular pharmacology, Apr, Volume: 35, Issue:4	Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (50.00)	18.7374
1990's	5 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.96 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.96)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (9.09%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dicyclomine Dicyclomine: A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.. dicyclomine : The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.	1.97	1	carboxylic ester; tertiary amine	antispasmodic drug; muscarinic antagonist; parasympatholytic
diphenidol diphenidol: shows anti-arrhythmic activity; RN given refers to unlabeled parent cpd. diphenidol : A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.	1.97	1	benzenes; piperidines; tertiary alcohol	antiemetic
hexahydrosiladifenidol [no description available]	3.99	4
methoctramine [no description available]	1.97	1	aromatic ether; tetramine	muscarinic antagonist
oxyphencyclimine oxyphencyclimine: minor descriptor (65-85); on-line & Index Medicus search PYRIMIDINES (65-85); RN given refers to parent cpd without isomeric designation	6.98	1	monocarboxylic acid
pirenzepine Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.	2.38	2	pyridobenzodiazepine	anti-ulcer drug; antispasmodic drug; muscarinic antagonist
procyclidine Procyclidine: A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.. procyclidine : A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.	6.98	1	pyrrolidines; tertiary alcohol	antidyskinesia agent; antiparkinson drug; muscarinic antagonist
muscarine Muscarine: A toxic alkaloid found in Amanita muscaria (fly fungus) and other fungi of the Inocybe species. It is the first parasympathomimetic substance ever studied and causes profound parasympathetic activation that may end in convulsions and death. The specific antidote is atropine.	1.97	1	monosaccharide
hexocyclium hexocyclium: RN given refers to parent cpd; structure	2.38	2	amine
n-methylscopolamine N-Methylscopolamine: A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.	1.98	1
methoctramine methoctramine: structure given in first source. methoctramine : A tetramine that is N,N'-bis(6-aminohexyl)octane-1,8-diamine where the primary amino groups both carry 2-methoxybenzyl substituents.. methoctramine tetrahydrochloride : A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.	6.97	1	hydrochloride	muscarinic antagonist
afdx 116 otenzepad: cardioselective muscarinic receptor antagonist; structure given in first source	1.97	1	benzodiazepine
silahexocyclium silahexocyclium: structure given in first source	2.38	2
atropine tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.	1.97	1
piperidines Piperidines: A family of hexahydropyridines.	4.68	9

Condition	Indicated	Relationship Strength	Studies	Trials
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	0	1.99	1	0
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	0	7.38	2	0

chemdatabank.com