Page last updated: 2024-12-08

he 11

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

nibentan: MF: C22-H29-N3-O3 HCl; MF does not agree with chemical name in text [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	177905
SCHEMBL ID	9571826
MeSH ID	M0274184

Synonyms (22)

Synonym
150491-98-8
nibentan
n-[5-(diethylamino)-1-phenylpentyl]-4-nitrobenzamide hydrochloride
AKOS005111093
n4s59zcs33 ,
unii-n4s59zcs33
157832-56-9
he 11
benzamide, n-(5-(diethylamino)-1-phenylpentyl)-4-nitro-, monohydrochloride
n-(5-(diethylamino)-1-phenylpentyl)-4-nitrobenzamide hydrochloride
FT-0682659
SCHEMBL9571826
benzamide, n-(5-(diethylamino)-1-phenylpentyl)-4-nitro-, hydrochloride (1:1)
nibentan [who-dd]
1-phenyl-1-((p-nitrobenzoyl)amino)-5-(n,n-diethylamino)pentane hydrochloride
n-[5-(diethylamino)-1-phenylpentyl]-4-nitrobenzamide;hydrochloride
DTXSID70933957
n-[5-(diethylamino)-1-phenylpentyl]-4-nitrobenzamide--hydrogen chloride (1/1)
(rs)-4-nitro-n-[1-phenyl-5-(diethylamino) pentyl]benzamide hydrochloride
Q27284549
n-(5-(diethylamino)-1-phenylpentyl)-4-nitrobenzamidehydrochloride
benzamide, n-[5-(diethylamino)-1-phenylpentyl]-4-nitro-, hydrochloride (1:1)

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" The most significant adverse effect was bradicardia, which was registered more often in the PC group than in EC group (26."	( [Comparison of the efficacy and safety of electrical cardioversion and pharmacological cardioversion with nibentan in patients with persisting atrial fibrillation and flutter]. Giliarov, MIu; Novikova, NA; Suchkova, SA; Sulimov, VA; Syrkin, AL, 2007)	0.34

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (17.65)	18.2507
2000's	13 (76.47)	29.6817
2010's	1 (5.88)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 47.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	47.43 (24.57)
Research Supply Index	3.30 (2.92)
Research Growth Index	4.48 (4.65)
Search Engine Demand Index	60.21 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (47.43)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (4.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	24 (96.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pentane Pentanes: Five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. pentane : A straight chain alkane consisting of 5 carbon atoms.	2	1	alkane; volatile organic compound	non-polar solvent; refrigerant
magnesium sulfate Magnesium Sulfate: A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083). magnesium sulfate : A magnesium salt having sulfate as the counterion.	2.03	1	magnesium salt; metal sulfate; organic magnesium salt	anaesthetic; analgesic; anti-arrhythmia drug; anticonvulsant; calcium channel blocker; cardiovascular drug; fertilizer; tocolytic agent
ibutilide ibutilide: RN & structure in first source; RN refers to the fumarate salt	2.01	1	benzenes; organic amino compound
uk 68798 [no description available]	2.01	1	aromatic ether; sulfonamide; tertiary amino compound	anti-arrhythmia drug; potassium channel blocker
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.04	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
sepharose agarose : A linear polysaccharide made up from alternating D-galactose and 3,6-anhydro-alpha-L-galactopyranose residues joined by alpha-(1->3)- and beta-(1->4)-linkages.	2.04	1

Condition	Relationship Strength	Studies	Trials
Acid beta-Glucosidase Deficiency [description not available]	2.04	1	0
Gaucher Disease An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.	2.04	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.42	2	0
Atrioventricular Nodal Re-Entrant Tachycardia [description not available]	2.04	1	0
Tachycardia, Ventricular An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).	2.04	1	0
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.01	1	0
Paroxysmal Reciprocal Tachycardia [description not available]	2.01	1	0
Tachycardia, Paroxysmal Abnormally rapid heartbeats with sudden onset and cessation.	2.01	1	0
Tachyarrhythmia [description not available]	2.01	1	0
Tachycardia Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.	2.01	1	0
Arrhythmia [description not available]	2.41	2	0
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	2.41	2	0
Auricular Fibrillation [description not available]	4.51	5	1
Atrial Fibrillation Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.	4.51	5	1
Auricular Flutter [description not available]	3.82	2	1
Torsade de Pointes [description not available]	2.03	1	0
Atrial Flutter Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).	3.82	2	1
Ventricular Fibrillation A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.	2	1	0

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