flumethiazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	8992
CHEMBL ID	2105128
CHEBI ID	135404
SCHEMBL ID	26534
MeSH ID	M0499369

Synonyms (62)

Synonym
trifluomethylthiazide
148-56-1
2h-1,4-benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
flumetiazid
ademol
nsc-44626
routrax
fludemil
flumethiazid
nsc44626
trifluoromethylthiazide
6-trifluoromethyl-7-sulfamoyl-4h-1,4-benzothiadiazine 1,1-dioxide
4h-1,4-benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
6-(trifluoromethyl)-1,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
flumethiazide
7-sulfamoyl-6-trifluoromethyl-2h-1,4-benzothiadiazine 1,1-dioxide
6-trifluoromethyl-7-sulfamyl-1,4-benzothiadiazine 1,1-dioxide
wln: t66 bswm enj hxfff iszw
ademil
6-(trifluoromethyl)-1,4-benzothiadiazine-7-sulfonamido 1,1-dioxide
4h-1,2,4-benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
flumethiazidum [inn-latin]
6-trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
6-(trifluoromethyl)-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide
7-sulfamoyl-6-trifluoromethyl-2h-1,2,4-benzothiadiazine 1,1-dioxide
6-(trifluoromethyl)-1,4,2-benzothiadiazine-7-sulfonamido 1,1-dioxide
nsc 44626
flumetiazida [inn-spanish]
flumetiazide [dcit]
hsdb 2845
6-trifluoromethyl-7-sulfamoyl-4h-1,2,4-benzothiadiazine 1,1-dioxide
flumethiazide [inn:ban]
flumethazide
einecs 205-717-4
6-trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide
6-trifluoromethyl-7-sulfamoyl-4h-1,4,2-benzothiadiazine 1,1-dioxide
6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
ademol (tn)
flumethiazide (inn)
D02453
CHEBI:135404
2h-1,2,4-benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide
trifluoromethyl thiazide
CHEMBL2105128
flumethiazidum
flumetiazide
flumetiazida
2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
3pa0cds0m5 ,
unii-3pa0cds0m5
SCHEMBL26534
flumethiazide [mi]
flumethiazide [who-dd]
flumethiazide [vandf]
flumethiazide [hsdb]
flumethiazide [inn]
6-trifluoromethyl-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
DTXSID60163862
1,1-dioxo-6-(trifluoromethyl)-4h-benzo[e][1,2,4]thiadiazine-7-sulfonamide
1,1-dioxo-6-(trifluoromethyl)-4h-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Q27257858
AKOS040751820

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" No evaluation was made in the remaining patient in the series because further adjustment in dosage was required."	( A new antihypertensive agent. Clinical evaluation of a Rauwolfia-flumethiazide combination (rautrax). NESCHE, GE, 1960)	0.48

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
benzothiadiazine	Heterocyclic compound of a ring with sulfur and two nitrogen atoms fused to a benzene ring. Members inhibit sodium-potassium-chloride symporters and are used as diuretics.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (20)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	16 (80.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (10.00)	24.3611
2020's	2 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	30.63 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	38.54 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (30.63)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetazolamide Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)	8.18	6	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor
amantadine amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source	2.15	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic
chlorothiazide Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812). thiazide : Heterocyclic compound with sulfur and nitrogen in the ring.. chlorothiazide : 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.	8.44	8	benzothiadiazine	antihypertensive agent; diuretic
hydrochlorothiazide Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.. hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.	6.93	1	benzothiadiazine; organochlorine compound; sulfonamide	antihypertensive agent; diuretic; environmental contaminant; xenobiotic
fludrocortisone Fludrocortisone: A synthetic mineralocorticoid with anti-inflammatory activity.	6.93	1	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; fluorinated steroid; mineralocorticoid	adrenergic agent; anti-inflammatory drug

Condition	Relationship Strength	Studies
Encephalopathy, Traumatic [description not available]	2.69	2
Acute Brain Injuries [description not available]	2.69	2
Brain Injuries, Traumatic A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.	2.69	2
Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.	2.69	2
Glaucoma, Suspect [description not available]	2.15	1
Intraocular Pressure The pressure of the fluids in the eye.	7.38	2
Ocular Hypertension A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.	2.15	1
Coronary Occlusion Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.	2.08	1
Cerebral Ischemia [description not available]	2.08	1
Acute Disease Disease having a short and relatively severe course.	2.08	1
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.08	1
Blood Pressure, High [description not available]	3.32	7
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	3.32	7
Anasarca [description not available]	1.93	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	6.93	1
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	2.34	2
Cardiac Failure [description not available]	1.93	1
Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.	1.93	1

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