Compounds > derquantel
Page last updated: 2024-11-13

derquantel

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

derquantel: an antihelmintic [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25154194
CHEMBL ID2103805
CHEBI ID188884
MeSH IDM0577600

Synonyms (29)

Synonym
derquantel (usan/inn)
187865-22-1
D09399
CHEBI:188884
(1s,6r,7r,9s,11r)-6-hydroxy-4',4',6,10,10,13-hexamethylspiro[3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane-11,8'-9,10-dihydro-[1,4]dioxepino[2,3-g]indole]-14-one
derquantel
spiro(4h,8h-(1,4)dioxepino(2,3-g)indole-8,7'(8'h)-(5h,6h- 5a,9a)(iminomethano)(1h)cyclopent(f)indolizin)-10'-one, 2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'r,5'as,7'r,8'as,9'ar)-
0l0ugk6oox ,
pf-00520904
(1'r,5'as,7'r,8'as,9'ar)-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-2',3',8'a,9,9',10-hexahydrospiro(4h,8h-(1,4)dioxepino(2,3-g)indole-8,7'(8'h)-(5h,6h- 5a,9a)(iminomethano)(1h)cyclopenta(f)indolizin)-10'-one
(1s,6r,7r,9s,11r)-6-hydroxy-4',4',6,10,10,13-hexamethyl-9',10'-dihydro-4'h-spiro(3,13-diazatetracyclo(5.5.2.01,9.03,7)tetradecane-11,8'-(1,4)dioxepino(2,3-g)indol)-14-one
derquantel [usan:inn]
unii-0l0ugk6oox
CHEMBL2103805
derquantel [usan]
(1'r,5'as,7'r,8'as,9'ar)-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-2',3',8'a,9,9',10-hexahydrospiro(4h,8h-(1,4)dioxepino(2,3-g)indole-8,7'(8'h)-(5h,6h-5a,9a)(iminomethano)(1h)cyclopenta(f)indolizin)-10'-one
spiro(4h,8h-(1,4)dioxepino(2,3-g)indole-8,7'(8'h)-(5h,6h-5a,9a)(iminomethano)(1h)cyclopent(f)indolizin)-10'-one, 2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'r,5'as,7'r,8'as,9'ar)-
derquantel [inn]
(1s,6r,7r,9s,11r)-6-hydroxy-4',4',6,10,10,13-hexamethyl-9',10'-dihydro-4'h-spiro(3,13-diazatetracyclo(5.5.2.0(sup 1,9).0(sup 3,7))tetradecane-11,8'-(1,4)dioxepino(2,3-g)indol)-14-one
J-012090
DTXSID50940260
1'-hydroxy-1',4,4,8',8',11'-hexamethyl-2',3',8'a,9,9',10-hexahydro-1'h,4h,5'h,6'h,8'h-spiro[1,4-dioxepino[2,3-g]indole-8,7'-[5a,9a](epiminomethano)cyclopenta[f]indolizin]-10'-one
NCGC00507976-02
Q27236920
CS-0089578
HY-125159
2-deoxoparaherquamide
AT37275
AKOS040745168
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
azaspiro compoundAn azaspiro compound is a spiro compound in which at least one of the cyclic components is a nitrogen heterocyle.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.34 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index39.34 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (23.08%)5.53%
Reviews2 (15.38%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (61.54%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
albendazole
[no description available]		2.1310aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator
aminoacetonitrile
Aminoacetonitrile: Cyanomethylamine.		6.2352
levamisole
Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.		2.1106-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazoleantinematodal drug;
antirheumatic drug;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
immunological adjuvant;
immunomodulator
closantel
closantel: structure. N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide : An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively.. closantel : A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections.		2.1310aromatic amide;
monocarboxylic acid amide;
monochlorobenzenes;
nitrile;
organoiodine compound;
phenols
pyrantel
Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920). pyrantel : A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.		2.13101,4,5,6-tetrahydropyrimidines;
carboxamidine;
thiophenes		antinematodal drug
tribendimidine
tribendimidine: structure given in first source		7.5220
oxepins
Oxepins: Compounds based on a 7-membered heterocyclic ring including an oxygen. They can be considered a medium ring ether. A natural source is the MONTANOA plant genus. Some dibenzo-dioxepins, called depsidones, are found in GARCINIA plants.		7.36123
dextrothyroxine
[no description available]		6.09103
monepantel
monepantel: Anthelmintic; effective gainst fourth stage gastro-intestinal nematode larvae infecting sheep. monepantel : A secondary carboxamide resulting from the formal condensation of the carboxy group of p-[(trifluoromethyl)sulfanyl]benzoic acid with the amino group of (2S)-2-amino-3-hydroxy-2-methylpropanenitrile in which the hydroxy group has been converted to the corresponding 5-cyano-2-(trifluoromethyl)phenyl ether. A broad-spectrum nematicide, it is used to control gastrointestinal roundworms in sheep and goats.		6.2352(trifluoromethyl)benzenes;
aromatic ether;
aryl sulfide;
nitrile;
secondary carboxamide		anthelminthic drug;
nematicide
moxidectin
moxidectin: family of macrolide antibiotics with insecticidal & acaricidal activity		8.8921
ConditionIndicatedRelationship StrengthStudiesTrials
Ovine Diseases
[description not available]		05.4272
Infections, Nematode
[description not available]		04.3841
Weight Gain
Increase in BODY WEIGHT over existing weight.		02.110
Infections, Nematomorpha
[description not available]		02.1310
Intestinal Diseases, Parasitic
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.		02.1310
Helminthiasis
Infestation with parasitic worms of the helminth class.		02.1310
Haemonchiasis
Infection with nematodes of the genus HAEMONCHUS, characterized by digestive abnormalities and anemia similar to that from hookworm infestation.		03.8921
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.4611