Compounds > communesin b
Page last updated: 2024-11-13

communesin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

communesin B: from ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44575539
CHEMBL ID509067
MeSH IDM0463805

Synonyms (8)

Synonym
communesin b
CHEMBL509067
148439-46-7
Q15410926
communesine b
DTXSID001017735
2,4-hexadien-1-one, 1-[(3ar,8ar,13br,16r,16as,17s)-17-[(2r)-3,3-dimethyl-2-oxiranyl]-2,3,8a,9,14,15-hexahydro-9-methyl-13,16-methano-8h,16h-pyrrolo[2',3':2,3]pyrido[4,3-o]quinindolin-1(16ah)-yl]-, (2e,4e)-
(2e,4e)-1-[(2s,6r,14r,22r,25s)-25-[(2r)-3,3-dimethyloxiran-2-yl]-15-methyl-1,3,13,15-tetrazaheptacyclo[18.4.1.02,6.06,22.07,12.014,22.016,21]pentacosa-7,9,11,16,18,20-hexaen-3-yl]hexa-2,4-dien-1-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID399251Toxicity in Artemia salina2004Journal of natural products, Jan, Volume: 67, Issue:1
New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
AID399249Antiproliferative activity against human L428 cells after 48 hrs by MTT assay2004Journal of natural products, Jan, Volume: 67, Issue:1
New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
AID399248Antiproliferative activity against human MOLT3 cells after 48 hrs by MTT assay2004Journal of natural products, Jan, Volume: 67, Issue:1
New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
AID399246Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay2004Journal of natural products, Jan, Volume: 67, Issue:1
New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
AID399245Antiproliferative activity against human U937 cells after 48 hrs by MTT assay2004Journal of natural products, Jan, Volume: 67, Issue:1
New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
AID399250Antiproliferative activity against human SUP-B15 cells after 48 hrs by MTT assay2004Journal of natural products, Jan, Volume: 67, Issue:1
New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
AID1103160Insecticidal activity against po dosed third-instar larvae of Bombyx mori assessed as gram of diet2004Bioscience, biotechnology, and biochemistry, Mar, Volume: 68, Issue:3
New insecticidal compounds, communesins C, D and E, from Penicillium expansum link MK-57.
AID399247Antiproliferative activity against human NAMALWA cells after 48 hrs by MTT assay2004Journal of natural products, Jan, Volume: 67, Issue:1
New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (76.92)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.67 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tryptamine
[no description available]		2.0310aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
physostigmine
Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.		2.0610carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.0410erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
isatin
tribulin: endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal;		2.0310indoledioneEC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite
indoline
indoline: structure given in first source		2.4520indoles
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		2.0610chromium group element atommicronutrient
phenserine
phenserine: a carbamate analog of physostigmine; a long-acting inhibitor of cholinesterase		2.0610
2-oxindole
2-oxindole: RN given refers to parent cpd; structure. indolin-2-one : An indolinone carrying an oxo group at position 2.		2.0610gamma-lactam;
indolinone
griseofulvin
Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.		2.02101-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite
perophoramidine
perophoramidine: from the Philippine ascidian Perophora namei; structure in first source		4.3860
minfiensine
minfiensine: structure in first source		3.1410
communesin f
communesin F: structure in first source		3.8230
communesin a
communesin A: structure in first source		4.2350
ConditionIndicatedRelationship StrengthStudiesTrials