Page last updated: 2024-12-10

8,8'-bieckol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

8,8'-bieckol: structure given in first source; antiplasmin antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3008867
CHEMBL ID443626
SCHEMBL ID1352492
MeSH IDM0172659

Synonyms (14)

Synonym
89445-12-5
7j2cfb3nbv ,
(2,2'-bidibenzo(b,e)(1,4)dioxin)-1,1',3,3',6,6',8,8'-octol, 9,9'-bis(3,5-dihydroxyphenoxy)-
unii-7j2cfb3nbv
9-(3,5-dihydroxyphenoxy)-2-[9-(3,5-dihydroxyphenoxy)-1,3,6,8-tetrahydroxy-dibenzo-p-dioxin-2-yl]dibenzo-p-dioxin-1,3,6,8-tetrol
[2,2'-bidibenzo[b,e][1,4]dioxin]-1,1',3,3',6,6',8,8'-octol, 9,9'-bis(3,5-dihydroxyphenoxy)-
8,8'-bieckol
CHEMBL443626 ,
SCHEMBL1352492
DTXSID20237710
bdbm50479419
Q4644251
8,8-bieckol
9,9'-bis(3,5-dihydroxyphenoxy)(2,2'-bidibenzo(b,e)(1,4)dioxin)-1,1',3,3',6,6',8,8'-octol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Protease Human immunodeficiency virus 1IC50 (µMol)81.50000.00000.81769.8500AID363928
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Reverse transcriptase/RNaseH Human immunodeficiency virus 1EC50 (µMol)0.51000.00040.61539.7000AID363916
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID363928Inhibition of HIV1 3B recombinant protease2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
Anti-HIV-1 activity of phloroglucinol derivative, 6,6'-bieckol, from Ecklonia cava.
AID363916Inhibition of HIV1 3B reverse transcriptase activity2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
Anti-HIV-1 activity of phloroglucinol derivative, 6,6'-bieckol, from Ecklonia cava.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.01 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]