Compounds > 3-ethyladenine
Page last updated: 2024-10-15

3-ethyladenine

Description

3-ethyladenine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135435067
CHEMBL ID2296738
SCHEMBL ID48200
MeSH IDM0078878

Synonyms (14)

Synonym
3-ethylpurin-6-amine
3h-purin-6-amine, 3-ethyl-
3-ethyladenine
43003-87-8
3-ethyl-3h-purin-6-amine
FT-0668138
AKOS006272830
3-n-ethyladenine
SCHEMBL48200
CHEMBL2296738
mfcd00800203
bdbm50488845
DTXSID10962847
3-ethyl-7h-purin-6-imine

Dosage Studied

ExcerptReference
" It was concluded that under controlled study conditions: (1) 1-OHP, S-PMA and t,t-MA are useful biomarkers that could differentiate exposure between smoking conventional and EHCSS cigarettes or between smoking conventional cigarettes and no smoking; between S-PMA and t,t-MA, the former appeared to be more sensitive; (2) 3-MeAd could only differentiate between smoking conventional cigarettes and no smoking; the results for 3-EtAd were not conclusive because contradictory results were observed; (3) 8-OHdG had a questionable association with smoking and therefore the utility of this biomarker for smoking-related exposure could not be established; and (4) urinary excretion of thioethers as a biomarker lacked sensitivity to demonstrate a clear dose-response relationship in conventional cigarette smokers, although it could differentiate the excretion levels between those subjects who smoked a conventional cigarette and those who stopped smoking."( Evaluation of urinary 1-hydroxypyrene, S-phenylmercapturic acid, trans,trans-muconic acid, 3-methyladenine, 3-ethyladenine, 8-hydroxy-2'-deoxyguanosine and thioethers as biomarkers of exposure to cigarette smoke.
Engl, J; Feng, S; Jin, Y; Kinser, R; Liang, Q; Riedel, K; Roethig, HJ; Scherer, G; Urban, M, )
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1123163Antiviral activity against HSV1 infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 6 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123168Antiviral activity against Vaccinia virus infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 6 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123165Antiviral activity against Vaccinia virus infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 50 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123160Antiviral activity against HSV1 infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 50 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123162Antiviral activity against HSV1 infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 12 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123164Antiviral activity against Vaccinia virus infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 100 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123161Antiviral activity against HSV1 infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 25 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123159Inhibition of bovine adrenal medullae dopamine-beta-hydroxylase1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123166Antiviral activity against Vaccinia virus infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 25 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
AID1123167Antiviral activity against Vaccinia virus infected in African green monkey BSC-1 cells assessed as inhibition of virus multiplication at 12 ug/ml after 96 hrs by plaque reduction assay1979Journal of medicinal chemistry, Feb, Volume: 22, Issue:2
3-Substituted adenines. In vitro enzyme inhibition and antiviral activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's4 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (10.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		3.38706-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ethylnitrosourea
Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.		1.9510N-nitrosoureasalkylating agent;
carcinogenic agent;
genotoxin;
mutagen
sodium hydroxide
Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)		1.9510alkali metal hydroxide
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		1.9810dihydrogen
6-ethylguanine
6-ethylguanine: found in rat brain DNA		1.9510
sepharose
agarose : A linear polysaccharide made up from alternating D-galactose and 3,6-anhydro-alpha-L-galactopyranose residues joined by alpha-(1->3)- and beta-(1->4)-linkages.		1.9810
guanine
[no description available]		7.7302-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3-methyladenine
N3-methyladenine: structure in first source		7.940
3-benzyladenine
[no description available]		2.3720
7-ethylguanine
[no description available]		7.3920oxopurine
ConditionIndicatedRelationship StrengthStudiesTrials
Gastroenteritis, Transmissible, of Swine
A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.		01.9510
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0810