1-phenyl-2,2,2-trifluoroethanol, also known as α,α,α-trifluoro-1-phenylethanol, is a chiral organic compound used as a building block in organic synthesis. It is a colorless liquid with a characteristic odor. The compound is known to be an effective chiral auxiliary for asymmetric synthesis, used for the preparation of various optically active compounds. 1-phenyl-2,2,2-trifluoroethanol is also a valuable intermediate in the pharmaceutical industry, being used in the synthesis of drugs, such as fluoxetine (Prozac) and other selective serotonin reuptake inhibitors (SSRIs). It is of interest for its unique electronic and steric properties, which can influence the reactivity and selectivity of chemical reactions. The compound has been used to study the effects of fluorine substitution on chemical reactivity and stability. It is also studied as a potential solvent in organic chemistry, particularly in reactions involving chiral catalysts.'
1-phenyl-2,2,2-trifluoroethanol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 95556 |
| CHEMBL ID | 320271 |
| SCHEMBL ID | 44838 |
| MeSH ID | M0521094 |
| Synonym |
|---|
| alpha-(trifluoromethyl) benzyl alcohol |
| nsc20214 |
| 340-05-6 |
| nsc-20214 |
| alpha-(trifluoromethyl)benzyl alcohol, 98% |
| (+/-)-alpha-(trifluoromethyl)benzyl alcohol, >=98.0% (gc) |
| CHEMBL320271 |
| 2,2,2-trifluoro-1-phenylethanol , |
| FT-0692053 |
| FT-0694382 |
| T1792 |
| alpha-(trifluoromethyl)benzyl alcohol |
| 1-phenyl-2,2,2-trifluoroethanol |
| 2,2,2-tris(fluoranyl)-1-phenyl-ethanol |
| A801194 |
| A822037 |
| A822039 |
| AKOS005207118 |
| 340-04-5 |
| 2,2,2-trifluoro-1-phenyl-ethanol |
| nsc 20214 |
| beta,beta,beta-trifluoro-alpha-hydroxyethylbenzene |
| einecs 206-429-1 |
| benzenemethanol, alpha-(trifluoromethyl)- |
| (1)-alpha-(trifluoromethyl)benzyl alcohol |
| benzyl alcohol, alpha-(trifluoromethyl)- |
| 2,2,2-trifluorophenylethanol |
| (s)-alpha-(trifluoromethyl)benzyl alcohol |
| alpha-(trifluoromethyl)benzenemethanol |
| einecs 206-430-7 |
| (r)-alpha-(trifluoromethyl)benzyl alcohol |
| einecs 234-094-1 |
| FT-0608233 |
| 2,2,2-trifluoro-1-phenylethan-1-ol |
| 10.14272/VNOMEAQPOMDWSR-UHFFFAOYSA-N |
| doi:10.14272/vnomeaqpomdwsr-uhfffaoysa-n |
| SCHEMBL44838 |
| 2R-0700 |
| alpha-- (trifluoromethyl) benzenemethanol |
| phenyltrifluoromethylcarbinol |
| a-trifluoromethyl benzyl alcohol |
| alpha-(trifluoromethyl) benzenemethanol |
| alpha-(trifluoromethyl)benzyl?alcohol |
| mfcd00004498 |
| J-506746 |
| J-019415 |
| alpha-(trifluoromethyl)benzylalcohol |
| (+/-)-alpha-(trifluoromethyl)benzyl alcohol |
| (+/-)-a-(trifluoromethyl)benzyl alcohol |
| 2,2,2-trifluoro-1-phenyl-1-ethanol |
| AMY7158 |
| xfnfcyfqkyujaa-uhfffaoysa-n |
| |a-(trifluoromethyl)benzyl alcohol |
| DTXSID50909418 |
| EN300-139082 |
| CS-0121625 |
| alpha -(trifluoromethyl)benzyl alcohol |
| (+/-)- alpha -(trifluoromethyl)benzyl alcohol |
| SY064700 |
| SY061787 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID82566 | In vitro cytotoxic activity against human gingival fibroblasts (HGF). | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Alpha-trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines. |
| AID85248 | In vitro cytotoxic activity against human salivary gland tumor (HSG) cells. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Alpha-trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines. |
| AID85243 | In vitro cytotoxic activity against human squamous cell carcinoma (HSC-2) cells. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Alpha-trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.77) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||