## 1,25-dihydroxy-24-oxo-vitamin D3: A Powerful Regulator
1,25-dihydroxy-24-oxo-vitamin D3 (also known as calcitroic acid) is a **metabolite of vitamin D3** (cholecalciferol). It plays a crucial role in **calcium homeostasis**, but its significance extends far beyond bone health.
**Here's a breakdown of its importance:**
**1. Calcium Regulation:**
* **Absorption:** Calcitroic acid is the active form of vitamin D3 and promotes calcium absorption in the intestines.
* **Bone Metabolism:** It also regulates calcium and phosphate levels in the blood, influencing bone formation and resorption.
**2. Beyond Bone Health:**
* **Immune System:** Calcitroic acid modulates immune function by influencing the activity of immune cells. It has been linked to the regulation of inflammatory responses and potentially plays a role in autoimmune diseases.
* **Cardiovascular Health:** Research suggests a potential role in cardiovascular health, with links to blood pressure regulation and the prevention of atherosclerosis.
* **Cancer:** Studies indicate that calcitroic acid might exhibit anti-proliferative and anti-cancer effects in various cancer types.
* **Cellular Signaling:** It acts as a hormone and interacts with specific receptors in cells, affecting various cellular processes.
**Research Significance:**
Calcitroic acid's diverse roles make it a highly interesting molecule for research. Here's why it's important:
* **New Therapeutic Targets:** Understanding its mechanisms of action could lead to the development of novel therapies for calcium-related disorders, autoimmune diseases, cardiovascular disease, and even cancer.
* **Understanding Vitamin D Metabolism:** Researching calcitroic acid provides insights into the complex metabolism of vitamin D and its diverse functions in the body.
* **Unveiling New Roles:** Further investigations into calcitroic acid's roles in various physiological processes could lead to the discovery of previously unknown functions.
**In Conclusion:** 1,25-dihydroxy-24-oxo-vitamin D3 is a powerful regulator with a vast scope of influence. Its importance in research lies in the potential to uncover new therapeutic targets, understand vitamin D metabolism, and unveil its full spectrum of functions in the human body.
1,25-dihydroxy-24-oxo-vitamin D3: vitamin D3 metabolite in chick intestinal mucosa homogenate [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5283703 |
| CHEBI ID | 47812 |
| SCHEMBL ID | 7139481 |
| MeSH ID | M0116191 |
| Synonym |
|---|
| (5z,7e)-(1s,3r)-1,3,25-trihydroxy-9,10-seco-5,7,10(19)-cholestatrien-24-one |
| 1alpha,25-dihydroxy-24-oxovitamin d3 / 1alpha,25-dihydroxy-24-oxocholecalciferol |
| LMST03020186 , |
| 24-oxo-1alpha,25-dihydroxyvitamin d3 |
| CHEBI:47812 |
| 24-kdhvd3 |
| 1,25-dihydroxy-24-oxo-vitamin d3 |
| 1,25-dihydroxy-24-oxocholecalciferol |
| 76338-50-6 |
| 24-keto-1,25-dihydroxyvitamin d3 |
| (1s,3r,5z,7e)-1,3,25-trihydroxy-9,10-secocholesta-5,7,10-trien-24-one |
| 24-oxo-1alpha,25-dihydroxycholecalciferol |
| 1alpha,25-dihydroxy-24-oxocholecalciferol |
| 24-oxo-1alpha,25(oh)2d3 |
| (1s)-1,25-dihydroxy-24-oxocalciol |
| 1alpha,25-dihydroxy-24-oxovitamin d3 |
| (6r)-6-[(1r,3as,4e,7ar)-4-[(2z)-2-[(3s,5r)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-1-yl]-2-hydroxy-2-methylheptan-3-one |
| SCHEMBL7139481 |
| 9,10-secocholesta-5,7,10(19)-trien-24-one, 1,3,25-trihydroxy-, (1alpha,3beta,5z,7e)- |
| Q27120806 |
| DTXSID201285609 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " 24-Keto-1,25-dihydroxyvitamin D3 is present in vivo in the plasma and small intestinal mucosa of rats fed a stock diet, receiving no exogenous 1,25-dihydroxyvitamin D3, and in the plasma and small intestinal mucosa of rats dosed chronically with 1,25-dihydroxyvitamin D3." | ( Intestinal synthesis of 24-keto-1,25-dihydroxyvitamin D3. A metabolite formed in vivo with high affinity for the vitamin D cytosolic receptor. Horst, RL; Napoli, JL; Pramanik, BC; Reinhardt, TA; Royal, PM, 1983) | 0.27 |
| Role | Description |
|---|---|
| human metabolite | Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| hydroxycalciol | |
| oxocalciol | |
| tertiary alpha-hydroxy ketone | An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.36) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||