Page last updated: 2024-11-05

2,6-naphthalenedicarboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2,6-naphthalenedicarboxylic acid is a white solid organic compound with the formula C14H8O4. It is a dicarboxylic acid with two carboxylic acid groups attached to the naphthalene ring at positions 2 and 6. The compound is a key intermediate in the synthesis of various important chemicals, including pigments, dyes, and polymers. It is also used as a precursor for the synthesis of other organic compounds with diverse applications. The compound has been studied extensively for its potential applications in the field of material science, due to its unique properties such as high thermal stability, good electrical conductivity, and strong fluorescence. The compound has also been investigated for its biological activity, particularly its potential as an antibacterial agent. Its synthesis involves various methods, including oxidation of 2,6-dimethylnaphthalene using potassium permanganate. The compound has also been synthesized through the Diels-Alder reaction of 1,4-naphthoquinone and maleic anhydride. The compound has been studied for its potential in various applications, including as a precursor for the synthesis of pharmaceuticals, dyes, and polymers. It has also been investigated for its potential in the development of new materials with specific properties.'

Cross-References

ID SourceID
PubMed CID14357
CHEMBL ID1205452
CHEBI ID44460
SCHEMBL ID18758
MeSH IDM0283143

Synonyms (49)

Synonym
CHEMBL1205452
nsc 96410
einecs 214-527-0
2,6-dicarboxynaphthalene
2,6-naphthalenedicarboxylic acid
2,6-naphthalic acid
nsc96410
nsc-96410
1141-38-4
2,6-naphthalenedicarboxylic acid, 99%
naphthalene-2,6-dicarboxylic acid
CHEBI:44460 ,
2,6-naphthalenedicarboxylic acid, 95%
NCIOPEN2_007124
DB08262
N0377
AKOS003235571
A803138
NCGC00248928-01
unii-k3c4dyz29o
k3c4dyz29o ,
tox21_201122
NCGC00258674-01
dtxsid5029211 ,
dtxcid009211
cas-1141-38-4
FT-0633397
PS-5917
2,6-naphthalene-dicarboxylic acid
2,6-napthalenedicarboxylic acid
naphthalenedicarboxylic acid, 2,6-
2,6-naphthalenedicarboxylic-acid
2,6-naphthalene dicarboxylic acid
2,6-naphthalendicarboxylic acid
SCHEMBL18758
W-108606
mfcd00004105
STL554395
CS-0048818
BBL100601
SB12742
Q2725546
2,6-naphthalic acid; nsc 96410; 2,6-naphthalenedicarboxylic acid; 2,6-naphthalenedicarboxylic acid
YSWG160
P10008
EN300-91471
PD005016
SY011270
Z276653308
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
dicarboxylic acidAny carboxylic acid containing two carboxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency53.62100.003041.611522,387.1992AID1159552; AID1159555
thyroid stimulating hormone receptorHomo sapiens (human)Potency27.55610.001628.015177.1139AID1259385
histone deacetylase 9 isoform 3Homo sapiens (human)Potency21.88860.037617.082361.1927AID1259364; AID1259388
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.37 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index48.31 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (39.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]