1,4-thiomorpholine-3,5-dicarboxylic acid

Description

1,4-thiomorpholine-3,5-dicarboxylic acid, also known as **TMC**, is a heterocyclic compound with a unique structural feature: a sulfur atom within the ring.

**Why is it important for research?**

TMC is a versatile scaffold for medicinal chemistry and material science research due to several key properties:

* **Bioactivity:** TMC and its derivatives have shown promising biological activities, including:
* **Anti-inflammatory:** TMC derivatives have been investigated as potential anti-inflammatory agents, particularly for treating inflammatory bowel disease (IBD).
* **Anti-cancer:** TMC-based compounds have exhibited anticancer activity against various types of cancer cells, including leukemia and colon cancer.
* **Antimicrobial:** TMC derivatives have shown antibacterial and antifungal properties.
* **Ligand for metal coordination:** The sulfur atom in the TMC ring can bind to various metal ions, making it a valuable ligand in coordination chemistry. This property has applications in fields like:
* **Catalysis:** TMC-derived metal complexes can act as catalysts in various chemical reactions.
* **Biomedical applications:** TMC-metal complexes have been explored for their potential use in drug delivery and imaging.
* **Scaffold for novel materials:** The rigid and functionalized structure of TMC can serve as a building block for the synthesis of novel materials, including:
* **Polymers:** TMC-based polymers can exhibit unique properties due to the presence of sulfur atoms, such as improved thermal stability and conductivity.
* **Organic semiconductors:** TMC-derived materials can be incorporated into organic electronic devices.

**In summary, TMC is a valuable research tool due to its bioactivity, ability to form metal complexes, and potential applications in materials science. Its unique structural features and diverse applications make it an active area of research in various fields.**

1,4-thiomorpholine-3,5-dicarboxylic acid: cyclic imino acid from bovine brain; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]