carboxyibuprofen

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

carboxyibuprofen: major urinary metabolite of ibuprofen; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

carboxyibuprofen : A dicarboxylic acid that is ibuprofen in which one of the methyl groups in the isobutyl portion has been converted to the corresponding carboxylic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	10444113
CHEMBL ID	3544650
CHEBI ID	133199
MeSH ID	M0285323

Synonyms (28)

Synonym
3-[4-(1-carboxyethyl)phenyl]-2-methylpropanoic acid
CHEBI:133199
ibuprofen cooh
2,4'-(2-carboxypropyl)phenylpropionic acid
15935-54-3
carboxyibuprofen
2-(4-(2-carboxypropyl)phenyl)propionic acid
unii-2ri5xr466k
benzenepropanoic acid, 4-(1-carboxyethyl)-alpha-methyl-
2ri5xr466k ,
benzeneacetic acid, 4-(2-carboxypropyl)-alpha-methyl-
FT-0670259
2-[4-(2-carboxypropyl)phenyl]propionic acid
benzenepropanoic acid, 4-(1-carboxyethyl)-.alpha.-methyl-
benzeneacetic acid, 4-(2-carboxypropyl)-.alpha.-methyl-
CHEMBL3544650
carboxyibuprofen, vetranal(tm), analytical standard
AKOS030255447
J-009596
ibuprofen carboxylic acid
FT-0670260
4-(2-carboxypropyl)-alpha-methyl-benzeneacetic acid
DTXSID401016127
Q27255512
benzenepropanoic acid, 4-(1-carboxyethyl)-?-methyl- (9ci); 2,4'-(2-carboxypropyl)phenylpropionic acid; 2-[4-(2-carboxypropyl)phenyl]propionic acid; 4-(2-carboxypropyl)-?-methylbenzeneacetic acid; carboxyibuprofen; ibuprofen cooh
3-(4-(1-carboxyethyl)phenyl)-2-methylpropanoic acid
4-(1-carboxyethyl)-alpha-methyl-benzenepropanoic acid
F77092

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
drug metabolite	null
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

Class	Description
dicarboxylic acid	Any carboxylic acid containing two carboxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

Pathway	Proteins	Compounds
Ibuprofen Action Pathway	50	76
Ibuprofen Metabolism Pathway	24	14

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (37.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.45

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	24.45 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	5.01 (4.65)
Search Engine Demand Index	23.28 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (24.45)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamazepine Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.. carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.	2.04	1	dibenzoazepine; ureas	analgesic; anticonvulsant; antimanic drug; drug allergen; EC 3.5.1.98 (histone deacetylase) inhibitor; environmental contaminant; glutamate transporter activator; mitogen; non-narcotic analgesic; sodium channel blocker; xenobiotic
clofibric acid Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.. clofibric acid : A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.	2.04	1	aromatic ether; monocarboxylic acid; monochlorobenzenes	anticholesteremic drug; antilipemic drug; antineoplastic agent; herbicide; marine xenobiotic metabolite; PPARalpha agonist
ibuprofen Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine	8.55	8	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic
caloreen caloreen: glucose polymer with average length of five glucose units for dietary energy supplement. dextrin : Glucans produced by the hydrolysis of starch or glycogen. They are mixtures of polymers of D-glucose units linked by alpha(1->4) or alpha(1->6) glycosidic bonds.	1.99	1
trimethoprim, sulfamethoxazole drug combination Trimethoprim, Sulfamethoxazole Drug Combination: A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.. co-trimoxazole : A two-component mixture comprising trimethoprim and sulfamethoxazole.	2.21	1
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	1.99	1	cyclodextrin
nitrofurantoin Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.	2.21	1	imidazolidine-2,4-dione; nitrofuran antibiotic; organonitrogen heterocyclic antibiotic; organooxygen heterocyclic antibiotic	antibacterial drug; antiinfective agent; hepatotoxic agent
hydroxyibuprofen hydroxyibuprofen: major urinary metabolite of ibuprofen; structure in first source. 2-hydroxyibuprofen : A hydroxy monocarboxylic acid that is ibuprofen in which the methine proton on the isobutyl group has been replaced by a hydroxy group.	8.42	7	hydroxy monocarboxylic acid; tertiary alcohol	drug metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	0	2.21	1	0

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