Pathways > Direct p53 effectors
Page last updated: 2024-10-06

Direct p53 effectors

Proteins (129)

ProteinSynonymsTaxonomy
PR domain zinc finger protein 1EC 2.1.1.-; BLIMP-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1; PRDI-BF1; PRDI-binding factor 1Homo sapiens (human)
Phorbol-12-myristate-13-acetate-induced protein 1PMA-induced protein 1; Immediate-early-response protein APR; Protein NoxaHomo sapiens (human)
NLR family CARD domain-containing protein 4CARD, LRR, and NACHT-containing protein; Clan protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; IpafHomo sapiens (human)
Epidermal growth factor receptorEC 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Hepatocyte growth factor receptorHGF receptor; EC 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase MetHomo sapiens (human)
Vitamin D3 receptorVDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1Homo sapiens (human)
G2/mitotic-specific cyclin-B1Homo sapiens (human)
Ephrin type-A receptor 2EC 2.7.10.1; Epithelial cell kinase; Tyrosine-protein kinase receptor ECKHomo sapiens (human)
Induced myeloid leukemia cell differentiation protein Mcl-1Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EATHomo sapiens (human)
Histone deacetylase 2HD2; EC 3.5.1.98Homo sapiens (human)
5'-AMP-activated protein kinase subunit beta-1AMPK subunit beta-1; AMPKbHomo sapiens (human)
5,6-dihydroxyindole-2-carboxylic acid oxidaseDHICA oxidase; EC 1.14.18.-; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1Homo sapiens (human)
Transcription factor Dp-1DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1Homo sapiens (human)
Tumor necrosis factor receptor superfamily member 10ADeath receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1Homo sapiens (human)
Mitogen-activated protein kinase kinase kinase kinase 4EC 2.7.11.1; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinaseHomo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Cathepsin DEC 3.4.23.5Homo sapiens (human)
72 kDa type IV collagenaseEC 3.4.24.24; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1Homo sapiens (human)
Apoptosis regulator Bcl-2Homo sapiens (human)
Caspase-1CASP-1; EC 3.4.22.36; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Homo sapiens (human)
B2 bradykinin receptorB2R; BK-2 receptorHomo sapiens (human)
Caspase-6CASP-6; EC 3.4.22.59; Apoptotic protease Mch-2Homo sapiens (human)
BH3-interacting domain death agonistp22 BID; BIDHomo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
Apoptosis regulator BAX Bcl-2-like protein 4; Bcl2-L-4Homo sapiens (human)
Dual specificity protein phosphatase 5EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase hVH3Homo sapiens (human)
Serine/threonine-protein kinase PLK3EC 2.7.11.21; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Proliferation-related kinaseHomo sapiens (human)
B-cell lymphoma 6 proteinBCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51Homo sapiens (human)
DNA mismatch repair protein Msh2hMSH2; MutS protein homolog 2Homo sapiens (human)
Caveolin-1Homo sapiens (human)
Insulin-like growth factor-binding protein 3IBP-3; IGF-binding protein 3; IGFBP-3Homo sapiens (human)
CCAAT/enhancer-binding protein zetaCCAAT-box-binding transcription factor; CBF; CCAAT-binding factorHomo sapiens (human)
Tumor necrosis factor receptor superfamily member 10BDeath receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2Homo sapiens (human)
Dickkopf-related protein 1Dickkopf-1; Dkk-1; hDkk-1; SKHomo sapiens (human)
Plasminogen activator inhibitor 1PAI; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1Homo sapiens (human)
Dual specificity protein phosphatase 1EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100Homo sapiens (human)
HuntingtinHuntington disease protein; HD proteinHomo sapiens (human)
Bcl-2 homologous antagonist/killerApoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7Homo sapiens (human)
Histone acetyltransferase KAT2AEC 2.3.1.48; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; hGCN5; Histone glutaryltransferase KAT2A; 2.3.1.-; Histone succinyltransferase KAT2A; 2.3.1.-; Lysine acetyltransferase 2A; STAF97Homo sapiens (human)
Bcl-2-binding component 3, isoforms 1/2JFY-1; p53 up-regulated modulator of apoptosisHomo sapiens (human)
SH2 domain-containing protein 1ADuncan disease SH2-protein; Signaling lymphocytic activation molecule-associated protein; SLAM-associated protein; T-cell signal transduction molecule SAPHomo sapiens (human)
14-3-3 protein sigmaEpithelial cell marker protein 1; StratifinHomo sapiens (human)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENEC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Mutated in multiple advanced cancers 1; Phosphatase and tensin homologHomo sapiens (human)
Protransforming growth factor alphaHomo sapiens (human)
Tumor necrosis factor receptor superfamily member 6Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptorHomo sapiens (human)
Antigen peptide transporter 1APT1; EC 7.4.2.-; ATP-binding cassette sub-family B member 2; Peptide supply factor 1; Peptide transporter PSF1; PSF-1; Peptide transporter TAP1; Peptide transporter involved in antigen processing 1; Really interesting new gene 4 protein; RING4Homo sapiens (human)
Cyclin-G1Cyclin-GHomo sapiens (human)
Apoptotic protease-activating factor 1APAF-1Homo sapiens (human)
Cyclin-KHomo sapiens (human)
Retinoblastoma-associated protein p105-Rb; p110-RB1; pRb; Rb; pp110Homo sapiens (human)
Glutathione peroxidase 1GPx-1; GSHPx-1; EC 1.11.1.9; Cellular glutathione peroxidaseHomo sapiens (human)
Proliferating cell nuclear antigenPCNA; CyclinHomo sapiens (human)
Hepatocyte growth factorHepatopoietin-A; Scatter factor; SFHomo sapiens (human)
Adenomatous polyposis coli proteinProtein APC; Deleted in polyposis 2.5Homo sapiens (human)
Cyclin-dependent kinase inhibitor 1CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21Homo sapiens (human)
Transcription factor E2F1E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1Homo sapiens (human)
Histone-arginine methyltransferase CARM1EC 2.1.1.319; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4Homo sapiens (human)
Caspase-10CASP-10; EC 3.4.22.63; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4Homo sapiens (human)
Protein arginine N-methyltransferase 1EC 2.1.1.319; Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4Homo sapiens (human)
Transcription factor Sp1Homo sapiens (human)
Growth/differentiation factor 15GDF-15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factorHomo sapiens (human)
Leukemia inhibitory factorLIF; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLIHomo sapiens (human)
Cyclic AMP-dependent transcription factor ATF-3cAMP-dependent transcription factor ATF-3; Activating transcription factor 3Homo sapiens (human)
DNA mismatch repair protein Mlh1 MutL protein homolog 1Homo sapiens (human)
Mismatch repair endonuclease PMS2EC 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2Homo sapiens (human)
Hepatocyte nuclear factor 3-alphaHNF-3-alpha; HNF-3A; Forkhead box protein A1; Transcription factor 3A; TCF-3AHomo sapiens (human)
Tumor protein 63p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51Homo sapiens (human)
Endothelin-2ET-2; Preproendothelin-2; PPET2Homo sapiens (human)
Transcription activator BRG1EC 3.6.4.-; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2 BEC 1.17.4.1; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2Homo sapiens (human)
Ferroptosis suppressor protein 1FSP1; EC 1.6.5.-; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; AMID; p53-responsive gene 3 proteinHomo sapiens (human)
Fructose-2,6-bisphosphatase TIGAREC 3.1.3.46; TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphataseHomo sapiens (human)
Protein PMLPromyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19Homo sapiens (human)
Apoptosis-associated speck-like protein containing a CARDhASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1Homo sapiens (human)
Tumor protein p53-inducible nuclear protein 1Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1Homo sapiens (human)
Probable ATP-dependent RNA helicase DDX5EC 3.6.4.13; DEAD box protein 5; RNA helicase p68Homo sapiens (human)
Protein NDRG1Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42Homo sapiens (human)
Tumor protein p73p53-like transcription factor; p53-related proteinHomo sapiens (human)
OsteopontinBone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; UropontinHomo sapiens (human)
NADPH:adrenodoxin oxidoreductase, mitochondrialAR; Adrenodoxin reductase; EC 1.18.1.6; Ferredoxin--NADP(+) reductase; Ferredoxin reductaseHomo sapiens (human)
Ribonuclease 3EC 3.1.26.3; Protein Drosha; Ribonuclease III; RNase III; p241Homo sapiens (human)
Microprocessor complex subunit DGCR8DiGeorge syndrome critical region 8Homo sapiens (human)
Exportin-2Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporterHomo sapiens (human)
Alpha-fetoproteinAlpha-1-fetoprotein; Alpha-fetoglobulinHomo sapiens (human)
Tumor necrosis factor receptor superfamily member 10DDecoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domainHomo sapiens (human)
FractalkineC-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1Homo sapiens (human)
Zinc finger protein SNAI2Neural crest transcription factor Slug; Protein snail homolog 2Homo sapiens (human)
p53-induced death domain-containing protein 1EC 3.4.21.-; Leucine-rich repeat and death domain-containing proteinHomo sapiens (human)
Sodium channel subunit beta-3Homo sapiens (human)
Protein BTG2BTG family member 2; NGF-inducible anti-proliferative protein PC3Homo sapiens (human)
Interferon regulatory factor 5IRF-5Homo sapiens (human)
Apoptosis facilitator Bcl-2-like protein 14Bcl2-L-14; Apoptosis regulator Bcl-GHomo sapiens (human)
Tumor necrosis factor receptor superfamily member 10CAntagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellHomo sapiens (human)
TP53-regulated inhibitor of apoptosis 1Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSVHomo sapiens (human)
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeAdenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X; NIP3LHomo sapiens (human)
Versican core proteinChondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan 2; Glial hyaluronate-binding protein; GHAP; Large fibroblast proteoglycan; PG-MHomo sapiens (human)
Nuclear transcription factor Y subunit alphaCAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YAHomo sapiens (human)
Growth arrest and DNA damage-inducible protein GADD45 alphaDNA damage-inducible transcript 1 protein; DDIT-1Homo sapiens (human)
Nuclear transcription factor Y subunit betaCAAT box DNA-binding protein subunit B; Nuclear transcription factor Y subunit B; NF-YBHomo sapiens (human)
CD82 antigenC33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27Homo sapiens (human)
Protein S100-A2CAN19; Protein S-100L; S100 calcium-binding protein A2Homo sapiens (human)
Serpin B5Maspin; Peptidase inhibitor 5; PI-5Homo sapiens (human)
Collagen alpha-1(XVIII) chainHomo sapiens (human)
TuberinTuberous sclerosis 2 proteinHomo sapiens (human)
Poly(rC)-binding protein 4Alpha-CP4Homo sapiens (human)
POU domain, class 4, transcription factor 1Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A; Homeobox/POU domain protein RDC-1; Oct-T1Homo sapiens (human)
POU domain, class 4, transcription factor 2Brain-specific homeobox/POU domain protein 3B; Brain-3B; Brn-3BHomo sapiens (human)
Nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C; NF-YC; Transactivator HSM-1/2Homo sapiens (human)
Hypermethylated in cancer 1 proteinHic-1; Zinc finger and BTB domain-containing protein 29Homo sapiens (human)
Transcription initiation factor TFIID subunit 9RNA polymerase II TBP-associated factor subunit G; STAF31/32; Transcription initiation factor TFIID 31 kDa subunit; TAFII-31; TAFII31; Transcription initiation factor TFIID 32 kDa subunit; TAFII-32; TAFII32Homo sapiens (human)
Quinone oxidoreductase PIG3EC 1.-.-.-; Tumor protein p53-inducible protein 3; p53-induced gene 3 proteinHomo sapiens (human)
Protein phosphatase 1JEC 3.1.3.16; Protein phosphatase 2C isoform zeta; PP2C-zetaHomo sapiens (human)
Metalloreductase STEAP3EC 1.16.1.-; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHydeHomo sapiens (human)
40S ribosomal protein S27-likeSmall ribosomal subunit protein eS27-likeHomo sapiens (human)
E3 ubiquitin-protein ligase RNF144BEC 2.3.2.31; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger proteinHomo sapiens (human)
Transcriptional adapter 2-betaADA2-like protein beta; ADA2-betaHomo sapiens (human)
Junction-mediating and -regulatory proteinHomo sapiens (human)
E3 ubiquitin-protein ligase COP1EC 2.3.2.27; Constitutive photomorphogenesis protein 1 homolog; hCOP1; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2Homo sapiens (human)
DNA damage-binding protein 2DDB p48 subunit; DDBb; Damage-specific DNA-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2Homo sapiens (human)
p53 apoptosis effector related to PMP-22Keratinocyte-associated protein 1; KCP-1; P53-induced protein PIGPC1; Transmembrane protein THWHomo sapiens (human)
RING finger and CHY zinc finger domain-containing protein 1EC 2.3.2.27; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363; p53-induced RING-H2 proteinHomo sapiens (human)
Zinc finger protein 385AHematopoietic zinc finger protein; Retinal zinc finger proteinHomo sapiens (human)
AT-rich interactive domain-containing protein 3AARID domain-containing protein 3A; B-cell regulator of IgH transcription; Bright; Dead ringer-like protein 1; E2F-binding protein 1Homo sapiens (human)
Regulator of cell cycle RGCCResponse gene to complement 32 protein; RGC-32Homo sapiens (human)
DNA damage-inducible transcript 4 proteinHIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1Homo sapiens (human)
Transformation/transcription domain-associated protein350/400 kDa PCAF-associated factor; PAF350/400; STAF40; Tra1 homologHomo sapiens (human)
Sestrin-1EC 1.11.1.-; p53-regulated protein PA26Homo sapiens (human)
RecName: Full=Heat shock 70 kDa protein 1A/1B; AltName: Full=Heat shock 70 kDa protein 1/2; Short=HSP70-1/HSP70-2; Short=HSP70.1/HSP70.2Homo sapiens (human)

Compounds (0)

CompoundDescription