Dickkopf-related protein 1

A dickkopf-related protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94907]

Synonyms

Dickkopf-1;
Dkk-1;
hDkk-1;
SK

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine	Homo sapiens (human)	EC50	0.6300	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
growth factor activity	molecular function	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]
co-receptor binding	molecular function	Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. [GOC:bf, GOC:jl]
receptor antagonist activity	molecular function	The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. [GOC:ceb, ISBN:0198506732]
low-density lipoprotein particle receptor binding	molecular function	Binding to a low-density lipoprotein receptor. [GOC:ai]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
early endosome membrane	cellular component	The lipid bilayer surrounding an early endosome. [GOC:pz]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 41 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
cell morphogenesis	biological process	The developmental process in which the size or shape of a cell is generated and organized. [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
endoderm formation	biological process	The formation of the endoderm during gastrulation. [GOC:go_curators]
mesoderm formation	biological process	The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:go_curators]
hair follicle development	biological process	The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. [GOC:dph, UBERON:0002073]
regulation of receptor internalization	biological process	Any process that modulates the frequency, rate or extent of receptor internalization. [GOC:hjd]
heart induction	biological process	The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart. [GOC:mtg_heart]
heart valve development	biological process	The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. [GOC:mtg_heart]
endocardial cushion development	biological process	The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart]
learning or memory	biological process	The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of neuron projection development	biological process	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]
negative regulation of Wnt signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. [GOC:dph, GOC:go_curators, GOC:tb]
negative regulation of ossification	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]
embryonic limb morphogenesis	biological process	The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. [GOC:bf, GOC:jl, ISBN:0395825172]
negative regulation of BMP signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. [GOC:go_curators]
forebrain development	biological process	The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain]
negative regulation of protein binding	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. [GOC:mah]
response to retinoic acid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl]
negative regulation of peptidyl-serine phosphorylation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]
negative regulation of mesodermal cell fate specification	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification. [GOC:go_curators]
regulation of endodermal cell fate specification	biological process	Any process that mediates the specification of a cell into an endoderm cell. [GOC:go_curators]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
regulation of neuron apoptotic process	biological process	Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
positive regulation of Wnt signaling pathway, calcium modulating pathway	biological process	Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). [GOC:go_curators]
positive regulation of JNK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
regulation of synaptic transmission, glutamatergic	biological process	Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
canonical Wnt signaling pathway	biological process	A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488]
limb development	biological process	The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. [GOC:dgh, GOC:dph, PMID:11487378]
face morphogenesis	biological process	The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. [GOC:dph]
negative regulation of SMAD protein signal transduction	biological process	Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. [GOC:BHF, GOC:dph, GOC:tb]
motor learning	biological process	Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience. [GOC:bf, GOC:PARL, Wikipedia:Motor_learning]
negative regulation of canonical Wnt signaling pathway	biological process	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:tb]
Wnt signaling pathway involved in somitogenesis	biological process	The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]
synapse pruning	biological process	A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190]
regulation of dopaminergic neuron differentiation	biological process	Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11433302]
positive regulation of midbrain dopaminergic neuron differentiation	biological process	Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
negative regulation of presynapse assembly	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
positive regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. [GOC:BHF]
negative regulation of cardiac muscle cell differentiation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]