Compounds > sb 216763
Page last updated: 2024-09-05

sb 216763 and cyc 202

sb 216763 has been researched along with cyc 202 in 8 studies

Compound Research Comparison

Studies
(sb 216763)		Trials
(sb 216763)		Recent Studies (post-2010)
(sb 216763)		Studies
(cyc 202)		Trials
(cyc 202)		Recent Studies (post-2010) (cyc 202)
34202259797393

Protein Interaction Comparison

ProteinTaxonomysb 216763 (IC50)cyc 202 (IC50)
Chain A, Homo sapiens cyclin-dependent kinase 2Homo sapiens (human)0.4
Chain C, Cell division protein kinase 2Homo sapiens (human)0.21
Chain C, Cell division protein kinase 2Homo sapiens (human)0.21
Dual specificity protein kinase CLK2Mus musculus (house mouse)0.71
Dual specificity protein kinase CLK4Mus musculus (house mouse)0.62
Cyclin-T1Homo sapiens (human)0.7646
G2/mitotic-specific cyclin-B2Homo sapiens (human)0.55
Serine/threonine-protein kinase PAK 4Homo sapiens (human)6.9
G1/S-specific cyclin-E2Homo sapiens (human)0.498
cGMP-dependent protein kinase 1 Bos taurus (cattle)0.305
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.305
Vitamin K-dependent protein CHomo sapiens (human)2.69
Cyclin-dependent kinase 1Homo sapiens (human)1.0801
G2/mitotic-specific cyclin-B1Homo sapiens (human)1.2287
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)0.37
Synapsin-1Bos taurus (cattle)1
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)0.305
Cyclin-A2Homo sapiens (human)0.8752
Dual specificity protein kinase CLK1Mus musculus (house mouse)2.75
G1/S-specific cyclin-E1Homo sapiens (human)0.2638
Cyclin-dependent kinase 2Homo sapiens (human)0.4921
Mitogen-activated protein kinase 1Homo sapiens (human)0.3167
Casein kinase I isoform alphaHomo sapiens (human)4
Casein kinase I isoform deltaHomo sapiens (human)10
Cyclin-dependent kinase 7Homo sapiens (human)0.5635
Cyclin-dependent kinase 9Homo sapiens (human)0.7534
Cyclin-HHomo sapiens (human)0.5614
CDK-activating kinase assembly factor MAT1Homo sapiens (human)2.2
Cyclin-A1Homo sapiens (human)1.3611
Casein kinase I isoform alphaRattus norvegicus (Norway rat)0.312
Cyclin-dependent-like kinase 5 Homo sapiens (human)0.3492
Cyclin-dependent-like kinase 5Bos taurus (cattle)0.2
Squalene synthaseRattus norvegicus (Norway rat)0.17
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)2.0437
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)0.3764
Dual specificity tyrosine-phosphorylation-regulated kinase 1AMus musculus (house mouse)5
G2/mitotic-specific cyclin-B3Homo sapiens (human)0.55
Dual specificity tyrosine-phosphorylation-regulated kinase 2Homo sapiens (human)1.7
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)0.37
Dual specificity tyrosine-phosphorylation-regulated kinase 1BHomo sapiens (human)1.2

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Duan, Y; Han, J; Hou, S; Liao, C; Wang, Q; Xie, Z; Yang, X1
Ohyashiki, T; Takadera, T1
Chen, L; Li, X; Salinas, GD1
Chen, YY; Chien, CL; Han, SK; Kan, D; Lee, WC; Lu, KS1
Jin, X; Kong, X; Li, G; Liu, T; Wang, L1

Reviews

1 review(s) available for sb 216763 and cyc 202

ArticleYear
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
    Journal of medicinal chemistry, 2022, 05-12, Volume: 65, Issue:9

    Topics: Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Drug Discovery; Humans; Neoplasms; Protein Kinase Inhibitors

2022

Other Studies

7 other study(ies) available for sb 216763 and cyc 202

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons.
    European journal of pharmacology, 2004, Sep-24, Volume: 499, Issue:3

    Topics: Animals; Apoptosis; Calcium; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinases; DNA Fragmentation; Dose-Response Relationship, Drug; Ethanol; Glycogen Synthase Kinase 3; Indoles; Intracellular Space; Maleimides; N-Methylaspartate; Peptides; Protein Kinase Inhibitors; Proteins; Purines; Rats; Roscovitine

2004
Regulation of serotonin 1B receptor by glycogen synthase kinase-3.
    Molecular pharmacology, 2009, Volume: 76, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Benzazepines; Cell Line; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred BALB C; Oxadiazoles; Oximes; Piperidines; Piperidones; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, Serotonin, 5-HT1B; Roscovitine; Serotonin; Spiro Compounds

2009
Suppression of extensive neurofilament phosphorylation rescues α-Internexin/peripherin-overexpressing PC12 cells from neuronal cell death.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animals; Cell Death; Cell Survival; Cyclin-Dependent Kinase 5; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Intermediate Filament Proteins; Maleimides; Membrane Glycoproteins; Mitochondria; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; PC12 Cells; Peripherins; Phosphorylation; Protein Transport; Purines; Rats; Roscovitine

2012
Hippocampal glycogen synthase kinase 3β is critical for the antidepressant effect of cyclin-dependent kinase 5 inhibitor in rats.
    Journal of molecular neuroscience : MN, 2014, Volume: 54, Issue:1

    Topics: 4-Butyrolactone; Animals; Antidepressive Agents; Chromones; Cyclin-Dependent Kinase 5; Depression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Helplessness, Learned; Hippocampus; Indoles; Male; Maleimides; Morpholines; Purines; Rats; Rats, Sprague-Dawley; Roscovitine

2014
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