mk 0663 has been researched along with promethazine in 4 studies
| Studies (mk 0663) | Trials (mk 0663) | Recent Studies (post-2010) (mk 0663) | Studies (promethazine) | Trials (promethazine) | Recent Studies (post-2010) (promethazine) |
|---|---|---|---|---|---|
| 549 | 173 | 265 | 3,110 | 299 | 235 |
| Protein | Taxonomy | mk 0663 (IC50) | promethazine (IC50) |
|---|---|---|---|
| Spike glycoprotein | Betacoronavirus England 1 | 5.86 | |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | 5.86 | |
| Transmembrane protease serine 2 | Homo sapiens (human) | 5.86 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.012 | |
| Procathepsin L | Homo sapiens (human) | 5.86 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 4.238 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.035 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0076 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.0046 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.681 | |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Replicase polyprotein 1ab | Human coronavirus 229E | 5.86 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 5.86 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.014 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.4395 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.053 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 2.431 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 2.596 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.02 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 2.744 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 4.238 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.165 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.183 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.045 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.012 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 2.596 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 5.8 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0041 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.559 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.068 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 2.429 | |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.287 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 5.86 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Antoniazzi, MM; Barbaro, KC; Faquim-Mauro, EL; Jared, SG; Kimura, LF; Pereira, NA; Prezotto-Neto, JP; Santoro, ML; Távora, BC; Teixeira, CF | 1 |
4 other study(ies) available for mk 0663 and promethazine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Mast cells and histamine play an important role in edema and leukocyte recruitment induced by Potamotrygon motoro stingray venom in mice.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Elasmobranchii; Etoricoxib; Fish Venoms; Histamine; Histamine H1 Antagonists; Leukocytes; Male; Mast Cells; Membrane Proteins; Mice; Promethazine; Prostaglandin D2; Pyridines; Rats; Sulfones | 2015 |