| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID414443 | AUC (0 to infinity) in castrated rat at 20 mg/kg, po | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414435 | Permeability across artificial membrane | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414441 | Cmax in castrated rat at 20 mg/kg, po | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID475055 | Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation counting | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor. |
| AID414434 | Metabolic stability in rat liver microsomes assessed as half life | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414450 | Ratio of Ki for human GnRH receptor to Ki for human non-selective opioid receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414452 | Ratio of Ki for human GnRH receptor to Ki for human histamine H2 receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414430 | Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reduction | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID475054 | Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation counting | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor. |
| AID414436 | Half life in castrated rat at 1 mg/kg, iv | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414433 | Aqueous solubility at pH 7.4 | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID475049 | Solubility at pH 7.4 | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor. |
| AID414439 | AUC (0 to infinity) in castrated rat at 1 mg/kg, iv | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414446 | Inhibition of human ERG potassium channel at 2 uM | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID475050 | Antagonist activity at GNRH receptor in rat pituitary cells assessed as inhibition of D-Trp6-GnRH-induced LH accumulation after 3 hrs by RIA | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor. |
| AID414453 | Reduction of serum LH level in castrated rat at 30 mg/kg, po after 6 hr | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414449 | Inhibition of human histamine H2 receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414431 | Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414432 | Antagonist activity at rat recombinant GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated LH release from rat pituitary cells | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414440 | Half life in castrated rat at 20 mg/kg, po | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414438 | Volume of distribution at steady state in castrated rat at 1 mg/kg, iv | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414447 | Inhibition of human non-selective opioid receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414429 | Displacement of [D-Trp6]-GnRH from rat recombinant GnRH receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414445 | Reduction of serum LH level in castrated rat at 30 mg/kg, po after 1 hr | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID475057 | Antagonist activity at human recombinant GNRH receptor assessed as inhibition of D-Trp6-GNRH-induced IP accumulation after 1 hr by rapid filtration assay | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor. |
| AID414448 | Inhibition of human neurokinin NK2 receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414442 | Tmax in castrated rat at 20 mg/kg, po | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414437 | Clearance in castrated rat plasma at 1 mg/kg, iv | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414444 | Oral bioavailability in castrated rat at 20 mg/kg | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID414451 | Ratio of Ki for human GnRH receptor to Ki for human neurokinin NK2 receptor | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID1346012 | Rat GnRH1 receptor (Gonadotrophin-releasing hormone receptors) | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| AID1346002 | Human GnRH1 receptor (Gonadotrophin-releasing hormone receptors) | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |