Compounds > tn 16
Page last updated: 2024-10-15

tn 16

Description

TN 16: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135427136
CHEMBL ID1736008
SCHEMBL ID6739845
SCHEMBL ID6739849
SCHEMBL ID13486640
MeSH IDM0114837

Synonyms (43)

Synonym
smr001570259
2, 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-
nsc-239274
33016-12-5
2, 3-(1-anilinoethylidene)-5-benzyl-
nsc239274
SMP2_000171
tn 16
nsc-100445
3-pyrrolin-2-one, 5-benzyl-4-hydroxy-3-(n-phenylacetimidoyl)-
nsc100445
mls002703542 ,
tn-16
3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione
(3z)-3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione
AKOS024341643
2,4-pyrrolidinedione, 3-(1-anilinoethylidene)-5-benzyl-
nsc 239274
2,4-pyrrolidinedione, 3-(1-(phenylamino)ethylidene)-5-(phenylmethyl)-
(3z)-3-(1-anilinoethylidene)-5-benzyl-pyrrolidine-2,4-quinone
(3z)-3-(1-anilinoethylidene)-5-(phenylmethyl)pyrrolidine-2,4-dione
bdbm97332
(3z)-3-(1-phenylazanylethylidene)-5-(phenylmethyl)pyrrolidine-2,4-dione
cid_5354005
T3877
SCHEMBL6739845
SCHEMBL6739849
SCHEMBL13486640
CHEMBL1736008
KWSXUGYAGMSUTN-LGMDPLHJSA-N
(3z)-3-(1-anilinoethylidene)-5-benzyl-2,4-pyrrolidinedione #
tn-16, >=98% (hplc)
5-benzyl-4-hydroxy-3-(n-phenylethanimidoyl)-1,5-dihydro-2h-pyrrol-2-one
J-018977
(e)-5-benzyl-3-(1-(phenylamino)ethylidene)pyrrolidine-2,4-dione
cid 5354005
6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)
AC-35569
mfcd02684017
STARBLD0009664
CS-0067596
HY-119357
AKOS040759262
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (13)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TDP1 proteinHomo sapiens (human)Potency0.00870.000811.382244.6684AID686978; AID686979
Smad3Homo sapiens (human)Potency1.75720.00527.809829.0929AID588855; AID720534; AID720536
67.9K proteinVaccinia virusPotency1.99530.00018.4406100.0000AID720580
IDH1Homo sapiens (human)Potency0.58050.005210.865235.4813AID686970
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency39.81070.354828.065989.1251AID504847
chromobox protein homolog 1Homo sapiens (human)Potency0.79430.006026.168889.1251AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency9.20000.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency2.51193.548119.542744.6684AID743266
gemininHomo sapiens (human)Potency0.16360.004611.374133.4983AID624297
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency1.31720.058010.694926.6086AID602310; AID651813
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency6.13720.025911.239831.6228AID602313; AID651814; AID651815
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)IC50 (µMol)15.80300.13430.86462.1450AID687017
steroidogenic factor 1Homo sapiens (human)IC50 (µMol)67.58101.87302.92953.9860AID687018
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (25.00)18.7374
1990's1 (8.33)18.2507
2000's2 (16.67)29.6817
2010's3 (25.00)24.3611
2020's3 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		1.9610amino-acid anion
iodoacetamide
[no description available]		1.9610
nocodazole
[no description available]		1.9610aromatic ketone;
benzimidazoles;
carbamate ester;
thiophenes		antimitotic;
antineoplastic agent;
microtubule-destabilising agent;
tubulin modulator
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		2.3720alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		1.9610diazine;
pyrazines		Daphnia magna metabolite
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		1.9610furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
n,n'-ethylenebis(iodoacetamide)
[no description available]		1.9610
nsc 181928
NSC 181928: potently stimulates tubulin-dependent GTP hydrolysis; member of 1-deaza-7,8-dihydropteridine class of mitotic inhibitors with antineoplastic activity; structure given in both sources		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Benign Neoplasms
[description not available]		02.2510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.2510
Adenocarcinoma Of Kidney
[description not available]		01.9810
Invasiveness, Neoplasm
[description not available]		01.9810
Carcinoma, Renal Cell
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.		01.9810