Page last updated: 2024-12-06

n,n'-ethylenebis(iodoacetamide)

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

n,n'-ethylenebis(iodoacetamide) is a bifunctional alkylating agent. It is a crosslinking reagent that is used to modify proteins and other biological macromolecules. The compound reacts with sulfhydryl groups (cysteine residues) in proteins, forming stable covalent bonds. The reaction results in cross-linking of two cysteine residues, leading to a change in protein structure and function. The compound has been used in a variety of research applications, such as: studying protein structure and function, developing new protein-based therapeutics, inhibiting enzyme activity, modifying the properties of biomaterials, and identifying the active sites of enzymes. Its importance lies in its ability to modify and study protein function through crosslinking.'

Cross-References

ID SourceID
PubMed CID23678
CHEMBL ID1911792
SCHEMBL ID134099
MeSH IDM0100518

Synonyms (33)

Synonym
nsc30028
7250-43-3
n,n'-ethylene-bis(iodoacetamide)
acetamide,n'-1,2-ethanediylbis[2-iodo-
wln: i1vm2mv1i
nsc-30028
acetamide,n'-ethylenebis[2-iodo-
s 35
ethylenediamine bis(iodoacetamide)
acetamide,n'-ethylenebis[iodo-
ethylenediaminebis(iodoacetamide)
brn 2444246
n,n'-1,2-ethanediylbis(2-iodoacetamide)
n,n'-ethylenebis(2-iodoacetamide)
acetamide, n,n'-ethylenebis(2-iodo-
acetamide, n,n'-ethylenebis(iodo-
nsc 30028
acetamide, n,n'-1,2-ethanediylbis(2-iodo-
n,n'-ethylenebis(iodoacetamide)
2-iodo-n-[2-[(2-iodoacetyl)amino]ethyl]acetamide
FT-0668247
n,n'-ethane-1,2-diylbis(2-iodoacetamide)
CHEMBL1911792
n,n-ethylenebis(iodoacetamide)
SCHEMBL134099
DTXSID10222812
AKOS028110606
acetamide, n,n'-1,2-ethanediylbis[2-iodo-
n,n'-(ethane-1,2-diyl)bis(2-iodoacetamide)
n,n'-ethylene-bis-(iodoacetamide)
Q27459888
STARBLD0001215
PD193284
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID626627Displacement of N,N'-ethylenebis(iodoacetamide) from beta-tubulin colchicine-binding site in human MDA-MB-231 cells at 1000 times IC50 preincubated for 2 hrs before N,N'-ethylenebis(iodoacetamide) addition measured after 1.5 hrs by chemiluminescence assay2011European journal of medicinal chemistry, Nov, Volume: 46, Issue:11
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (64.71)18.7374
1990's4 (23.53)18.2507
2000's0 (0.00)29.6817
2010's2 (11.76)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.29 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]