Compounds > talwin nx

Page last updated: 2024-10-15

talwin nx

Description

talwin Nx: combination of pentazocine HCl and naloxone HCl intended to discourage abuse of pentazocine as a heroin substitute [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	122707132
MeSH ID	M0143548

Synonyms (7)

Synonym
dea no. 9709
talwin nx
morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-, mixt. with (2alpha,6alpha,11r*)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol
pentazocine - naloxone mixt.
92522-87-7
naloxone-pentazocine mixt.
naloxone / pentazocine

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (50.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (20.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	2 (40.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	1 (20.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
ibuprofen Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine	3.43	1	1	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic
tripelennamine Tripelennamine: A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.	2.37	2	0	aromatic amine
pentazocine Pentazocine: The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)	10.38	4	1	benzazocine
naloxone Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.	5.38	4	1	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist

Condition	Indicated	Relationship Strength	Studies	Trials
Acute Post-operative Pain [description not available]	0	4.71	2	1
Periodontitis, Acute Nonsuppurative [description not available]	0	3.43	1	1
Inflammation, Endodontic [description not available]	0	3.43	1	1
Odontalgia [description not available]	0	4.71	2	1
Pain, Postoperative Pain during the period after surgery.	0	4.71	2	1
Periapical Periodontitis Inflammation of the PERIAPICAL TISSUE. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is PERIAPICAL GRANULOMA. Suppurative inflammation is PERIAPICAL ABSCESS.	0	3.43	1	1
Pulpitis Inflammation of the DENTAL PULP, usually due to bacterial infection in dental caries, tooth fracture, or other conditions causing exposure of the pulp to bacterial invasion. Chemical irritants, thermal factors, hyperemic changes, and other factors may also cause pulpitis.	0	3.43	1	1
Toothache Pain in the adjacent areas of the teeth.	0	4.71	2	1
Craniofacial Pain [description not available]	0	2.9	1	0
Facial Pain Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.	0	2.9	1	0
Chemical Dependence [description not available]	0	2.37	2	0
Psychoses, Drug [description not available]	0	1.97	1	0
Substance-Related Disorders Disorders related to substance use or abuse.	0	2.37	2	0