Page last updated: 2024-11-11

riccardin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

riccardin A: an 18 carbon macrocyclic ether; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14330572
CHEMBL ID475625
MeSH IDM0269931

Synonyms (3)

Synonym
riccardin a
CHEMBL475625
5-methoxy-14-oxapentacyclo[20.2.2.210,13.115,19.02,7]nonacosa-1(24),2(7),3,5,10(29),11,13(28),15,17,19(27),22,25-dodecaene-16,24-diol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID371666Agonist activity at full length LXRalpha expressed in african green monkey COS7 cells co-transfected with RXRalpha assessed as increase in LXR-response element driven luciferase reporter gene transactivation at 10 to 30 uM after 24 hrs2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRalpha agonists.
AID602901Vasorelaxant activity in Wistar rat endothelium-denuded aortic rings assessed as inhibition of phenylephrine-induced contractions at 10 to 100 uM after 10 to 60 mins2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts.
AID602900Vasorelaxant activity in Wistar rat endothelium-intact aortic rings assessed as inhibition of phenylephrine-induced contractions at 10 to 100 uM after 10 to 60 mins2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts.
AID371667Agonist activity at full length LXRbeta expressed in african green monkey COS7 cells co-transfected with RXRalpha assessed as increase in LXR-response element driven luciferase reporter gene transactivation at 10 to 30 uM after 24 hrs2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRalpha agonists.
AID666156Inhibition of Influenza Viral Focus Formation at 13 uM relative to control2011PloS one, , Volume: 6, Issue:5
Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.
AID666155Inhibition of Influenza Viral Focus Formation at 50 uM relative to control2011PloS one, , Volume: 6, Issue:5
Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.
AID666151Inhibition of PA endonuclease at 1 uM2011PloS one, , Volume: 6, Issue:5
Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.
AID602898Vasorelaxant activity in Wistar rat endothelium-intact aortic rings assessed as inhibition of phenylephrine-induced contractions after 10 to 60 mins2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts.
AID602897Vasorelaxant activity in Wistar rat endothelium-intact aortic rings assessed as inhibition of phenylephrine-induced contractions at 30 uM after 10 to 30 mins2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts.
AID602899Vasorelaxant activity in Wistar rat endothelium-intact aortic rings assessed as inhibition of phenylephrine-induced contractions at 10 to 100 uM2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts.
AID404052Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pretreated 1 hr before LPS challenge after 24 hrs by Griess reagent method2005Journal of natural products, Dec, Volume: 68, Issue:12
Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: a study of structure-activity relationships and molecular mechanism.
AID666150Inhibition of PA endonuclease at 10 uM2011PloS one, , Volume: 6, Issue:5
Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]