| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
5-methoxypsoralen
5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.. 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5. | 2.06 | 1 | 0 | 5-methoxyfurocoumarin;
organic heterotricyclic compound;
psoralens | hepatoprotective agent;
plant metabolite |
methoxsalen
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis. | 2.06 | 1 | 0 | aromatic ether;
psoralens | antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite |
thiazoles
[no description available] | 2.05 | 1 | 0 | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
imperatorin
imperatorin: tumor necrosis factor antagonist; furanocoumarin from West African medicinal plant Clausena anisata; structure in Negwer, 5th ed, #3005. imperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor. | 2.06 | 1 | 0 | psoralens | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite |
osthol
osthol: from Cnidium monnieri and Angelica pubescens (both Apiaceae); structure given in first source | 2.06 | 1 | 0 | botanical anti-fungal agent;
coumarins | metabolite |
isopimpinellin
isopimpinellin: from Ruta graveolens & Heracleum lanatum; structure | 2.06 | 1 | 0 | psoralens | |
isoimperatorin
isoimperatorin: tumor necrosis factor antagonist isolated from Glehniae root. isoimperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor. | 2.06 | 1 | 0 | psoralens | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite |
magnolol
[no description available] | 2.06 | 1 | 0 | biphenyls | |
honokiol
[no description available] | 2.06 | 1 | 0 | biphenyls | |
phellopterin
phellopterin: a naturally occurring furanocoumarin found in roots of Angelica dahurica; structure in first source | 2.06 | 1 | 0 | psoralens | |
marchantin a
marchantin A: 16 carbon macrocyclic bis-ether bis-bibenzyl similar to riccardin A; from liverwort Marchantia polymorpha; structure in first source | 2.06 | 1 | 0 | phenylpropanoid | |
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene. | 2.98 | 4 | 0 | stilbene | |
rhodamine 123
Rhodamine 123: A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30). rhodamine 123(1+) : A cationic fluorescent dye derived from 9-phenylxanthene. | 2.05 | 1 | 0 | organic cation;
xanthene dye | fluorochrome |
5,6-dehydrokawain
5,6-dehydrokawain: from Alpinia speciosa rhizoma; RN given for cpd without isomeric designation; structure given in first source | 2.06 | 1 | 0 | 2-pyranones;
aromatic ether | |
kavain
[no description available] | 2.06 | 1 | 0 | 2-pyranones;
aromatic ether | |
methysticin
[no description available] | 2.06 | 1 | 0 | 2-pyranones;
aromatic ether | |
yangonin
yangonin: structure in first source | 2.06 | 1 | 0 | 2-pyranones;
aromatic ether | |
marchantin c
marchantin C: Antineoplastic Agents, Phytogenic from liverwort Marchantia paleacea; structure in first source | 2.06 | 1 | 0 | | |
dihydrokavain
dihydrokavain: inhibits binding of batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated sodium channels | 2.06 | 1 | 0 | 2-pyranones;
aromatic ether | |
riccardin a
riccardin A: an 18 carbon macrocyclic ether; structure given in first source | 2.06 | 1 | 0 | | |