Page last updated: 2024-12-07
pyrrolomycin a
Description
pyrrolomycin A: chlorinated nitropyrrole from Actinomycetes strain SF-2080; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
pyrrolomycin A : A member of the class of pyrroles that is 1H-pyrrole which is substituted by chloro groups at positions 2 and 3 and by a nitro group position 4. It is the simplest member of the pyrrolomycins, a family of natural products found in several species of the Streptomyces genus. The compound is active against Gram-positive and Gram-negative bacteria and some genera of fungi. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 133275 |
| CHEMBL ID | 152571 |
| CHEBI ID | 156550 |
| SCHEMBL ID | 9124172 |
| MeSH ID | M0102495 |
Synonyms (16)
| Synonym |
|---|
| pyrrole, 2,3-dichloro-4-nitro- |
| 2,3-dichloro-4-nitropyrrole |
| brn 6195547 |
| 79763-01-2 |
| pyrrolmycin-a |
| pyrrolomycin a |
| sf-2080a |
| 2,3-dichloro-4-nitro-1h-pyrrole |
| 1h-pyrrole, 2,3-dichloro-4-nitro |
| 1h-pyrrole, 2,3-dichloro-4-nitro- |
| CHEMBL152571 |
| CHEBI:156550 |
| AKOS006280143 |
| CDHAYBUDIPNGGJ-UHFFFAOYSA-N |
| DTXSID50229906 |
| SCHEMBL9124172 |
Roles (2)
| Role | Description |
|---|
| bacterial metabolite | Any prokaryotic metabolite produced during a metabolic reaction in bacteria. |
| antibacterial agent | A substance (or active part thereof) that kills or slows the growth of bacteria. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (4)
| Class | Description |
|---|
| C-nitro compound | A nitro compound having the nitro group (-NO2) attached to a carbon atom. |
| pyrroles | An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton. |
| organochlorine compound | An organochlorine compound is a compound containing at least one carbon-chlorine bond. |
| antibiotic antifungal agent | Heteroorganic entities that are microbial metabolites (or compounds derived from them) which have significant antifungal properties. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID44953 | Antifungal activity against Candida albicans C-A-24 strain | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
| Synthesis and quantitative structure-activity relationship analysis of N-triiodoallyl- and N-iodopropargylazoles. New antifungal agents. |
| AID211166 | Antifungal activity towards Trichophyton interdigitale | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
| Synthesis and quantitative structure-activity relationship analysis of N-triiodoallyl- and N-iodopropargylazoles. New antifungal agents. |
| AID55013 | Antifungal activity against Cryptococcus neoformans Cr-1 strain | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
| Synthesis and quantitative structure-activity relationship analysis of N-triiodoallyl- and N-iodopropargylazoles. New antifungal agents. |
| AID39669 | Antifungal activity against Aspergillus fumigatus Saito strain | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
| Synthesis and quantitative structure-activity relationship analysis of N-triiodoallyl- and N-iodopropargylazoles. New antifungal agents. |
| AID214099 | Antifungal activity towards Trichophyton mentagrophytes 530324 strain | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
| Synthesis and quantitative structure-activity relationship analysis of N-triiodoallyl- and N-iodopropargylazoles. New antifungal agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.38
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.38 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.32 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |