Compounds > oxomemazine
Page last updated: 2024-12-06

oxomemazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

oxomemazine: selective for M1 muscarinic receptors [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID19396
CHEMBL ID2104734
CHEBI ID135408
SCHEMBL ID423634
MeSH IDM0306120

Synonyms (86)

Synonym
AC-15943
oxomemazine
10h-phenothiazine-10-propanamine, n,n,.beta.-trimethyl-, 5,5-dioxide
3-(5,5-dioxido-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine
3689-50-7
10-(3-(dimethylamino)-2-methylpropyl)phenothiazine 5,5-dioxide
oxomemazina [inn-spanish]
oxomemazine [inn:dcf]
doxergan
phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-, 5,5-dioxide
dioxo-9,9-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine [french]
oxymemazine
dysedon
imakol
alimemazine s,s-dioxide
10-(3-(dimethylamino)-2-methylpropyl)phenothiazine-5,5-dioxide
oxomemazinum [inn-latin]
dosegran
brn 0289178
rp 6847
einecs 222-996-8
oxomemazine (inn)
doxergan (tn)
D07401
CHEBI:135408
3-(5,5-dioxophenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine
NCGC00182075-02
NCGC00182075-03
CHEMBL2104734
6487-rp
oplex
rp-6847
6847-rp
exe-top
trimeprazine 5,5-dioxide
AKOS015962134
4-27-00-01270 (beilstein handbook reference)
oxomemazinum
oxomemazina
dioxo-9,9-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine
6847 r.p.
unii-305mb38v1c
305mb38v1c ,
oxomemazin
oxomemazine [inn]
oxomemazine [mart.]
156576-01-1
oxomemazine [mi]
(+/-)-oxomemazine
oxomemazine [who-dd]
SCHEMBL423634
smr004701064
MLS006009989
3-(5,5-dioxido-10h-phenothiazin-10-yl)-n,n,2-trimethyl-1-propanamine #
QTQPVLDZQVPLGV-UHFFFAOYSA-N
6487 rp
6847 rp
phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-, 5,5-dioxide
10-(3-(dimethylamino)-2-methylpropyl)-10h-phenothiazine 5,5-dioxide
FT-0698324
DTXSID5023405
unii-5gp9538p4s
10h-phenothiazine-10-propanamine, n,n,beta-trimethyl-, 5,5-dioxide, (-)-
10h-phenothiazine-10-propanamine, n,n,beta-trimethyl-, 5,5-dioxide, (+)-
unii-q824sgh3rn
SR-01000883964-1
sr-01000883964
(-)-oxomemazine
10h-phenothiazine-10-propanamine, n,n,.beta.-trimethyl-, 5,5-dioxide, (-)-
oxomemazine, (-)-
174508-13-5
oxomemazine, (+)-
10h-phenothiazine-10-propanamine, n,n,.beta.-trimethyl-, 5,5-dioxide, (+)-
5GP9538P4S ,
174508-14-6
Q824SGH3RN ,
(+)-oxomemazine
F20164
oxomemazine 1.0 mg/ml in methanol
trimeprazine sulphone; oxomemazine
Q3359071
mfcd00868197
DB13820
HY-136587
CS-0131898
MS-24971

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The proposed methods have been applied successfully for the analysis of the drug in pure form and in its dosage forms."( Extractive spectrophotometric methods for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations using bromocresol green, bromocresol purple and bromophenol blue.
El-Didamony, AM, 2005)		0.57
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenothiazines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Oxomemazine H1-Antihistamine Action87

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 80.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index80.17 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index133.90 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (80.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cyproheptadine
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.. cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.		1.9310piperidines;
tertiary amine		anti-allergic agent;
antipruritic drug;
gastrointestinal drug;
H1-receptor antagonist;
serotonergic antagonist
pirenzepine
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.		1.9810pyridobenzodiazepineanti-ulcer drug;
antispasmodic drug;
muscarinic antagonist
promethazine
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.. promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.		1.9310phenothiazines;
tertiary amine		anti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
sedative
trimeprazine
Trimeprazine: A phenothiazine derivative that is used as an antipruritic.		1.9310phenothiazines
bromcresol green
Bromcresol Green: An indicator and reagent. It has been used in serum albumin determinations and as a pH indicator.		2.0210benzofurans
phenothiazine
10H-phenothiazine : The 10H-tautomer of phenothiazine.		1.9310phenothiazineferroptosis inhibitor;
plant metabolite;
radical scavenger
bromphenol blue
Bromphenol Blue: A dye that has been used as an industrial dye, a laboratory indicator, and a biological stain.. bromophenol blue : 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye.		2.02102,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
phenols;
sultone		acid-base indicator;
dye;
two-colour indicator
bromcresol purple
Bromcresol Purple: An indicator and reagent. It has been used for several purposes including the determination of serum albumin concentrations. bromocresol purple : A member of the class of 2,1-benzoxathioles that is 2,1-benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3-bromo-4-hydroxy-5-methylphenyl groups. A hydrophilic dye that is used as a pH indicator and to measure serum albumin concentrations.		2.02102,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
polyphenol;
sultone		acid-base indicator;
dye;
two-colour indicator
methotrimeprazine
Methotrimeprazine: A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604). methotrimeprazine : A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.		1.9310phenothiazines;
tertiary amine		anticoronaviral agent;
cholinergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
non-narcotic analgesic;
phenothiazine antipsychotic drug;
serotonergic antagonist
ConditionIndicatedRelationship StrengthStudiesTrials
Anaphylactic Reaction
[description not available]		01.9310
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		01.9310