octafluorocyclobutane profile

Octafluorocyclobutane is a colorless, odorless gas with a boiling point of -4.5 °C. It is a highly fluorinated cyclic hydrocarbon that is chemically inert and non-flammable. It is synthesized by the fluorination of cyclobutane or by the reaction of tetrafluoroethylene with fluorine. Octafluorocyclobutane is used as a refrigerant, a blowing agent for foams, and a dielectric fluid in electrical equipment. It is also studied for its potential as a greenhouse gas substitute. The compound is known for its high thermal stability and low toxicity. Its chemical inertness makes it useful in applications where high temperatures and corrosive environments are encountered. The study of octafluorocyclobutane's properties and applications is ongoing due to its potential as a sustainable and environmentally friendly alternative to traditional refrigerants and blowing agents.'

perfluorocyclobutane: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

octafluorocyclobutane : A fluorocarbon that is cyclobutane in which all eight hydrogens are replaced by fluorines. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	8263
CHEMBL ID	444147
CHEBI ID	31007
MeSH ID	M0051179

Synonym
einecs 204-075-2
r-c 318
fc-c 318
un1976
halocarbon c-138
propellant c318
CHEBI:31007 ,
e 946
115-25-3
perfluorocyclobutane
cyclobutane, octafluoro-
cyclooctafluorobutane
e946
freon c 318
freon 318
octafluorocyclobutane
e-946
1,1,2,2,3,3,4,4-octafluorocyclobutane
freon c-318
CHEMBL444147
O0204
FT-0676233
v9p1d0a21k ,
octafluorocyclobutane, or refrigerant gas r c318
cyclobutane, 1,1,2,2,3,3,4,4-octafluoro-
unii-v9p1d0a21k
octafluorocyclobutane, or refrigerant gas r c318 [un1976] [nonflammable gas]
AKOS015853421
freon c318
octafluorocyclobutane [mi]
r c318
un 1976
1,1,2,2,3,3,4,4-octafluorocyclobutane #
propellant c 318
W-108594
DTXSID9041811
mfcd00040334
fluorocarbon c-318
c318
1,1,2,2,3,3,4,4-octafluoro-cyclobutane
octafluoro-cyclobutane
Q413079

Role	Description
food packaging gas	A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
food propellant	A propellant that is used to expel foods from an aerosol container.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
fluorocarbon	Compounds consisting wholly of fluorine and carbon.
cyclobutanes	Cyclobutane and its derivatives formed by substitution.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID416913	Convulsant activity in Sprague-Dawley rat assessed as partial pressure in atmosphere at which convulsion takes place	2009	European journal of medicinal chemistry, Feb, Volume: 44, Issue:2	Prediction of convulsant activity of gases and vapors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (26.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (20.00)	29.6817
2010's	5 (33.33)	24.3611
2020's	3 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (13.33%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (86.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	1.96	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
octane Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. octane : A straight chain alkane composed of 8 carbon atoms.	2.05	1	alkane	xenobiotic
acetylene [no description available]	1.96	1	alkyne; gas molecular entity; terminal acetylenic compound
tetrafluoromethane tetrafluoromethane: structure in first source	2.06	1	fluorocarbon; fluoromethanes	refrigerant
1,1,2-trichloro-1,2,2-trifluoroethane [no description available]	2.05	1	chlorofluorocarbon; haloalkane	NMR solvent; refrigerant
freon 114 Freon 114: InChIKey: DDMOUSALMHHKOS-UHFFFAOYSA-N	2.05	1
chloropentafluoroethane [no description available]	2.05	1	organochlorine compound; organofluorine compound
perflutren Definity: a fluorocarbon-filled ultrasonic contrast agent; Definity is tradename. octafluoropropane : A fluorocarbon that is propane in which all of the hydrogens have been replaced by fluorines.	2.05	1	fluoroalkane; fluorocarbon
pentane Pentanes: Five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. pentane : A straight chain alkane consisting of 5 carbon atoms.	2.05	1	alkane; volatile organic compound	non-polar solvent; refrigerant
cyclohexane Cyclohexane: C6H12. cyclohexane : An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.	2.05	1	cycloalkane; volatile organic compound	non-polar solvent
nonane iotrochotin: toxin from the Caribbean sponge Iotrochota birotulata, which selectively permeabilizes synaptosomes. nonane : A straight chain alkane composed of 9 carbon atoms.	2.05	1	alkane	plant metabolite; volatile oil component
hexafluoropropene [no description available]	2.06	1
cyclooctane [no description available]	2.05	1
flurothyl Flurothyl: A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.	2.05	1	ether
pentafluoroethane [no description available]	2.06	1
1,2-dichloro-1,2,3,3,4,4-hexafluorocyclobutane [no description available]	2.05	1
sulfur hexafluoride Sulfur Hexafluoride: Sulfur hexafluoride. An inert gas used mainly as a test gas in respiratory physiology. Other uses include its injection in vitreoretinal surgery to restore the vitreous chamber and as a tracer in monitoring the dispersion and deposition of air pollutants.. sulfur hexafluoride : A sulfur coordination entity consisting of six fluorine atoms attached to a central sulfur atom. It is the most potent greenhouse gas currently known, with a global warming potential of 23,900 times that of CO2 over a 100 year period (SF6 has an estimated lifetime in the atmosphere of between 800 and 3,000 years).	2.4	2	sulfur coordination entity	greenhouse gas; NMR chemical shift reference compound; ultrasound contrast agent
helium Helium: A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics.	1.96	1	monoatomic helium; noble gas atom; s-block element atom	food packaging gas
fluorine Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.	2.45	2	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
2,3-dichlorooctafluorobutane [no description available]	2.05	1
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	7.49	2	carbon group element atom; metalloid atom; nonmetal atom

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1
Recrudescence [description not available]	1.96	1
Adhesions, Tissue [description not available]	1.96	1
Retinal Pigment Epithelial Detachment [description not available]	1.96	1
Retinal Detachment Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).	1.96	1
Eye Hemorrhage Intraocular hemorrhage from the vessels of various tissues of the eye.	1.97	1
Complication, Postoperative [description not available]	1.97	1
Choroid Hemorrhage Hemorrhage from the vessels of the choroid.	1.97	1
Glaucoma An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)	1.97	1
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	1.97	1

octafluorocyclobutane

Description

Cross-References

Synonyms (42)

Roles (2)

Drug Classes (2)

Bioassays (1)

Research

Studies (15)

Market Indicators

Research Demand Index: 32.98

Study Types