1,1,2-trichloro-1,2,2-trifluoroethane profile

1,1,2-trichloro-1,2,2-trifluoroethane, commonly known as **CFC-113**, is a **halogenated hydrocarbon** with the chemical formula **C2Cl3F3**.

**Importance in Research:**

While CFC-113 itself is not directly used in contemporary research due to its **environmental impact**, its **historical significance** and **properties** make it relevant for research in several areas:

* **Ozone depletion:** CFC-113 was a widely used **refrigerant and solvent** before its production was phased out due to its role in **ozone layer depletion**. Studying CFC-113 and its degradation pathways in the atmosphere helped scientists understand **ozone depletion mechanisms** and develop regulations to protect the ozone layer.
* **Atmospheric chemistry:** CFC-113's persistence in the atmosphere and its unique chemical properties make it a valuable tracer for studying **atmospheric transport and mixing**. Scientists use its presence and concentration to track atmospheric circulation patterns and understand the global distribution of pollutants.
* **Environmental monitoring:** Monitoring residual levels of CFC-113 in the atmosphere allows scientists to track the **effectiveness of international regulations** aimed at phasing out ozone-depleting substances.
* **Material science:** CFC-113's low boiling point and high dielectric constant made it useful as a **cleaning agent and solvent** for electronic components. This has contributed to research on **alternative solvents** and **cleaner manufacturing processes**.

**Current Research:**

While CFC-113 is not actively researched, it serves as a model compound for studying **halogenated hydrocarbons** and their environmental impacts. The knowledge gained from studying CFC-113 helps researchers develop safer alternatives and understand the long-term effects of human activities on the environment.

**Summary:**

Although CFC-113 is no longer widely used, its past significance and unique properties contribute to research in areas like ozone depletion, atmospheric chemistry, environmental monitoring, and material science. Its study allows scientists to develop a better understanding of the environmental impact of halogenated hydrocarbons and develop sustainable alternatives.

ID Source	ID
PubMed CID	6428
CHEMBL ID	478511
CHEBI ID	193131
SCHEMBL ID	62713
MeSH ID	M0051181

Synonym
arcton 63
ethane, 1,1,2-trichloro-1,2,2-trifluoro-
1,1,2-trichloro-1,2,2-trifluoroethane
76-13-1
1,1,2-trichloro-1,2,2-trifluoroethane, technical grade
f 113
freon 113tr-t
flugene 113
frigen 113a
einecs 200-936-1
ai3-62874
fc 113
ucon fluorocarbon 113
frigen 113tr
freon 113
brn 1740335
1,1,2-trichlorotrifluoroethane
hsdb 145
halocarbon 113
1,1,2-trifluorotrichloroethane
daiflon s 3
refrigerant r 113
propellant 113
frigen 113tr-t
frigen 113tr-n
racon 113
freon r 113
kaiser chemicals 11
r 113 (halocarbon)
r 113
genetron 113
frigen 113 tr
chlorofluorocarbon 113
asahifron 113
freon f113
genesolv d
1,2,2-trichlorotrifluoroethane
kaltron 113mdr
1,1,2-trifluoro-1,2,2-trichloroethane
refrigerant 113
forane 113
isceon 113
ledon 113
frigen 113
frigen 113 tr-t
freon tf
arklone p
khladon 113
fluorocarbon 113
1,1,2-trichloro-1,2,2-trifluoroethane (cfc-113)
cfc-113
ajdizqlsfpqpey-uhfffaoysa-
inchi=1/c2cl3f3/c3-1(4,6)2(5,7)8
CHEMBL478511
CHEBI:193131
AKOS000120164
NCGC00248592-01
dtxsid6021377 ,
dtxcid601377
NCGC00257955-01
tox21_200401
cas-76-13-1
unii-0739n04x3a
cfc 113
0739n04x3a ,
FT-0605980
SCHEMBL62713
desflurane impurity g [ep impurity]
1,1,2-trichloro-1,2,2-trifluoroethane [hsdb]
r-113
1,1,2-trichlor-1,2,2-trifluorethane
1,1,2-trichloro-1,2,2-trifluoro-ethane
1,2,2-trifluoroperchloroethane
1,2,2-trifluorotrichloroethane
cfcl2cf2cl
1,1,2-trichloro-1,2,2-trifluoroetane
1,1,2-trichloro -1,2,2-trifluoroethane
1,1,2-trifluoro-trichloroethane
1,1,2-tri-fluorotrichloroethane
1,1,2-trichlorotrifiuoroethane
1,2,2-trichloro-1,1,2-trifluoroethane
1,1,2-trichloro-1,2,2-trifluoro ethane
fc 133
freon 113 tr-t
freon tf (113)
r 113(halocarbon)
delifrene ls
halon 113
distillex ds5
trichloro 1,2,2-trifluoroethane
arklone
1,1,2-trichlorotrifuoroethane
1,1,2-trichlorotrifluoroethane, hplc grade, >=99.9%
1,1,2-trichloro-1,2,2-trifluoroethane, for hplc, >=99.7% (gc)
1,1,2-trichlorotrifluoroethane, reagentplus(r), 99%
1,1,2-trichlorotrifluoroethane, anhydrous, 99.8%
1,1,2-trichloro-1,2,2-trifluoroethane, acs spectrophotometric grade, >=99.8%
trichlorotrifluoroethane, european pharmacopoeia (ep) reference standard
1,1,2-trichlorotrifluoroethane 100 microg/ml in methanol
1,1,2-trichlorotrifluoroethane 10 microg/ml in methanol
freon-113
F8889-9400
Q161276
AMY22255
mfcd00000782
1,1,2-trichloro-1,2,2-trifluoroethane 2000 microg/ml in methanol

Excerpt	Relevance	Reference
" The higher lidocaine dosage administered (21 mg) did not intensify the positive impact on the cardiovascular parameters compared to the lower dosage (14 mg)."	( Effects of different lidocaine sprays for topical anesthesia on cardiovascular parameters and oxygen saturation. Daubländer, M; Lipp, M; Roth, W, 1992)	0.28

Role	Description
refrigerant	A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
NMR solvent	A solvent used in nuclear magnetic resonance (NMR) spectroscopy.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
chlorofluorocarbon	An organochlorine compound derived from methane, ethane or propane that contains atoms of carbon, chlorine, and fluorine only. They are nontoxic, nonflammable chemicals used in aerosol sprays and as refrigerants. Being ozone depletion agents, their manufacture and use is being phased out under the Montreal Protocol.
haloalkane	A halohydrocarbon that is an alkane in which at least one hydrogen atom has been replaced by with a halogen atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
GLI family zinc finger 3	Homo sapiens (human)	Potency	76.5677	0.0007	14.5928	83.7951	AID1259369
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	41.0562	0.0008	17.5051	59.3239	AID1159527; AID1159531
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID416913	Convulsant activity in Sprague-Dawley rat assessed as partial pressure in atmosphere at which convulsion takes place	2009	European journal of medicinal chemistry, Feb, Volume: 44, Issue:2	Prediction of convulsant activity of gases and vapors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (30.77)	18.7374
1990's	10 (38.46)	18.2507
2000's	5 (19.23)	29.6817
2010's	3 (11.54)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (3.70%)	5.53%
Reviews	1 (3.70%)	6.00%
Case Studies	4 (14.81%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (77.78%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
octane Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. octane : A straight chain alkane composed of 8 carbon atoms.	2.44	2	0	alkane	xenobiotic
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2	1	0	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	2.02	1	0	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
albuterol Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).	2.41	2	0	phenols; phenylethanolamines; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; environmental contaminant; xenobiotic
cetylpyridinium Cetylpyridinium: Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.	3.36	1	1	pyridinium ion
lidocaine Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.	3.36	1	1	benzenes; monocarboxylic acid amide; tertiary amino compound	anti-arrhythmia drug; drug allergen; environmental contaminant; local anaesthetic; xenobiotic
ethylene Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges	2.21	1	0	alkene; gas molecular entity	plant hormone; refrigerant
methylene chloride Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.	1.98	1	0	chloromethanes; volatile organic compound	carcinogenic agent; polar aprotic solvent; refrigerant
carbon disulfide Carbon Disulfide: A colorless, flammable, poisonous liquid, CS2. It is used as a solvent, and is a counterirritant and has local anesthetic properties but is not used as such. It is highly toxic with pronounced CNS, hematologic, and dermatologic effects.	1.97	1	0	one-carbon compound; organosulfur compound
fluorocarbon 22 [no description available]	1.99	1	0	hydrochlorofluorocarbon
bromotrifluoromethane [no description available]	1.98	1	0
trichlorofluoromethane trichlorofluoromethane: refrigerant, aerosol propellant; RN given refers to parent cpd; structure. trichlorofluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by three chlorine and one fluorine atom.	3.59	2	0	chlorofluorocarbon; halomethane	environmental contaminant; NMR chemical shift reference compound; NMR solvent; refrigerant
dichlorodifluoromethane dichlorodifluoromethane: refrigerant,aerosol propellant	3.83	3	0
freon 114 Freon 114: InChIKey: DDMOUSALMHHKOS-UHFFFAOYSA-N	3.59	2	0
chloropentafluoroethane [no description available]	2.05	1	0	organochlorine compound; organofluorine compound
perflutren Definity: a fluorocarbon-filled ultrasonic contrast agent; Definity is tradename. octafluoropropane : A fluorocarbon that is propane in which all of the hydrogens have been replaced by fluorines.	2.05	1	0	fluoroalkane; fluorocarbon
trichloroethylene Trichloroethylene: A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.. triol : A chemical compound containing three hydroxy groups.	8.09	5	0	chloroethenes	inhalation anaesthetic; mouse metabolite
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	2.02	1	0	alkane
pentane Pentanes: Five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. pentane : A straight chain alkane consisting of 5 carbon atoms.	2.05	1	0	alkane; volatile organic compound	non-polar solvent; refrigerant
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	1.98	1	0	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
cyclohexane Cyclohexane: C6H12. cyclohexane : An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.	2.05	1	0	cycloalkane; volatile organic compound	non-polar solvent
nonane iotrochotin: toxin from the Caribbean sponge Iotrochota birotulata, which selectively permeabilizes synaptosomes. nonane : A straight chain alkane composed of 9 carbon atoms.	2.05	1	0	alkane	plant metabolite; volatile oil component
octafluorocyclobutane perfluorocyclobutane: structure in first source. octafluorocyclobutane : A fluorocarbon that is cyclobutane in which all eight hydrogens are replaced by fluorines.	2.05	1	0	cyclobutanes; fluorocarbon	food packaging gas; food propellant
cyclooctane [no description available]	2.05	1	0
2,2-dichloro-1,1,1-trifluoroethane 2,2-dichloro-1,1,1-trifluoroethane: structure given in first source. hydrochlorofluorocarbon : An organochlorine compound derived from methane, ethane or propane that contains atoms of hydrogen, chlorine, fluorine, and carbon only.	3.27	1	0
flurothyl Flurothyl: A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.	2.05	1	0	ether
pentafluoroethane [no description available]	3.27	1	0
1,1,1-trichloro-2,2,2-trifluoroethane [no description available]	3.27	1	0
1,2-dichloro-1,2,3,3,4,4-hexafluorocyclobutane [no description available]	2.05	1	0
1,1,1-trifluoroethane [no description available]	3.27	1	0
2,2,4-trimethylpentane 2,2,4-trimethylpentane: nephrotoxic. isooctane : An alkane that consists of pentane bearing two methyl substituents at position 2 and a single methyl substituent at position 4.	2.02	1	0	alkane; volatile organic compound	fuel additive; nephrotoxin; non-polar solvent
norflurane norflurane: may replace R 12 as air-conditioning refrigerant; structure given in first source	3.27	1	0
1,1-dichloro-1-fluoroethane [no description available]	3.27	1	0
1,1,1,2-tetrafluoro-2-chloroethane 1,1,1,2-tetrafluoro-2-chloroethane: refrigerant	3.27	1	0
ozone Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.	2.05	1	0	elemental molecule; gas molecular entity; reactive oxygen species; triatomic oxygen	antiseptic drug; disinfectant; electrophilic reagent; greenhouse gas; mutagen; oxidising agent; tracer
salmeterol xinafoate Salmeterol Xinafoate: A selective ADRENERGIC BETA-2 RECEPTOR agonist that functions as a BRONCHODILATOR when administered by inhalation. It is used to manage the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE.	2.41	2	0	naphthoic acid
apaflurane [no description available]	2	1	0
1,1,1,3,3-pentafluoropropane [no description available]	3.27	1	0
2,3-dichlorooctafluorobutane [no description available]	2.05	1	0
2,3,3,3-tetrafluoropropene 2,3,3,3-tetrafluoropropene: structure in first source	3.27	1	0
fluticasone Fluticasone: A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS.. fluticasone : A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.	2.41	2	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 3-oxo-Delta(4) steroid; corticosteroid; fluorinated steroid; thioester	anti-allergic agent; anti-asthmatic drug

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.05	1
Convalescence The period of recovery following an illness.	1.93	1
Encephalitis, Polio [description not available]	1.93	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	1.93	1
Acute Liver Injury, Drug-Induced [description not available]	1.95	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	1.95	1
Auricular Fibrillation [description not available]	1.98	1
Cardiac Arrest, Sudden [description not available]	1.98	1
Atrial Fibrillation Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.	1.98	1
Death, Sudden, Cardiac Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)	1.98	1
Nasal Bleeding [description not available]	1.99	1
Blood Pressure, High [description not available]	1.99	1
Age-Related Memory Disorders [description not available]	1.99	1
Diseases, Occupational [description not available]	1.99	1
Day Blindness [description not available]	1.99	1
Epistaxis Bleeding from the nose.	1.99	1
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	1.99	1
Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.	1.99	1
Anemia, Hypochromic Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)	1.97	1
Cardiac Complex, Premature [description not available]	1.97	1
Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.	1.97	1
Burns, Chemical Burns caused by contact with or exposure to CAUSTICS or strong ACIDS.	1.97	1
Burns, Inhalation Burns of the respiratory tract caused by heat or inhaled chemicals.	1.97	1

1,1,2-trichloro-1,2,2-trifluoroethane

Cross-References

Synonyms (106)

Research Excerpts

Dosage Studied

Roles (2)

Drug Classes (2)

Protein Targets (2)

Potency Measurements

Bioassays (1)

Research

Studies (26)

Market Indicators

Research Demand Index: 36.60

Study Types