Page last updated: 2024-11-06

ngp 1-01

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

NGP 1-01: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID129903676
MeSH IDM0142152

Synonyms (3)

Synonym
ngp 1-01
ngp1-01
n-benzyl[?]amine

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Effects observed in the isolated guinea-pig atria and ileum were, respectively, reversal of CaCl2 induced positive chronotropy and inotropy and papaverine-like depression of the dose-response curve induced by acetyl choline."( Characterization of NGP 1-01, an aromatic polycyclic amine, as a calcium antagonist.
Coetzee, WA; Squier, GJ; Van der Schyf, CJ, 1986
)
0.27
" In a separate study, brain damage 3 days after stroke was determined histologically in mice receiving no treatment, DMSO, or NGP1-01 (dosages and dosage schedule same as above)."( Neuroprotection in mice by NGP1-01 after transient focal brain ischemia.
Abbruscato, TJ; Bickel, U; Geldenhuys, WJ; Hao, J; Klein, J; Mdzinarishvili, A; Van der Schyf, CJ, 2008
)
0.35
" Two different gradient slope chromatography runs were done on dosed mouse serum samples to assess a possible positive error in peak area determination from in-source fragmentation of metabolites generating the same MRM transitions as the parent drug or IS."( Development and validation of an LC-MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum.
Anderson, DJ; Crish, SD; Geldenhuys, WJ; Gobburi, AL; Jogiraju, H; Pedada, KK; Van der Schyf, CJ; Zhou, X, 2014
)
0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]